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Feasibility of evidence-based diagnosis and management of heart failure in older people in care: a pilot randomised controlled trial.

Abstract：

BACKGROUND:Many older people in long-term care do not receive evidence-based diagnosis or management for heart failure; it is not known whether this can be achieved for this population. We initiated an onsite heart failure service, compared with 'usual care' with the aim of establishing the feasibility of accurate diagnosis and appropriate management. METHODS:A pilot randomised controlled trial which randomised residents from 33 care facilities in North-East England with left ventricular systolic dysfunction (LVSD) to usual care or an onsite heart failure service. The primary outcome was the optimum prescription of angiotensin-converting enzyme inhibitors and beta-adrenergic antagonists at 6 months. RESULTS:Of 399 echocardiographically-screened residents aged 65-100 years, 30 subjects with LVSD were eligible; 28 (93%) consented and were randomised (HF service: 16; routine care: 12). Groups were similar at baseline; six month follow-up was completed for 25 patients (89%); 3 (11%) patients died. Results for the primary outcome were not statistically significant but there was a consistent pattern of increased drug use and titration to optimum dose in the intervention group (21% compared to 0% receiving routine care, p=0.250). Hospitalisation rates, quality of life and mortality at 6 months were similar between groups. CONCLUSIONS:This study demonstrated the feasibility of an on-site heart failure service for older long-term care populations. Optimisation of medication appeared possible without adversely affecting quality of life; this questions clinicians' concerns about adverse effects in this group. This has international implications for managing such patients. These methods should be replicated in a large-scale study to quantify the scale of benefit. TRIAL REGISTRATION:ISRCTN19781227 http://www.controlled-trials.com/ISRCTN19781227

journal_name

BMC Geriatr

journal_title

BMC geriatrics

authors

Hancock HC,Close H,Mason JM,Murphy JJ,Fuat A,de Belder M,Hunt T,Baker A,Wilson D,Hungin AP

doi

10.1186/1471-2318-12-70

subject

Has Abstract

pub_date

2012-11-14 00:00:00

pages

issn

1471-2318

pii

1471-2318-12-70

journal_volume

pub_type

杂志文章,多中心研究,随机对照试验

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Feasibility of evidence-based diagnosis and management of heart failure in older people in care: a pilot randomised controlled trial.