Comparison of pharmacy-based measures of medication adherence.

Abstract:

BACKGROUND:Pharmacy databases are commonly used to assess medication usage, and a number of measures have been developed to measure patients' adherence to medication. An extensive literature now supports these measures, although few studies have systematically compared the properties of different adherence measures. METHODS:As part of an 18-month randomized clinical trial to assess the impact of automated telephone reminders on adherence to inhaled corticosteroids (ICS) among 6903 adult members of a managed care organization, we computed eight pharmacy-based measures of ICS adherence using outpatient pharmacy dispensing records obtained from the health plan's electronic medical record. We used simple descriptive statistics to compare the relative performance characteristics of these measures. RESULTS:Comparative analysis found a relative upward bias in adherence estimates for those measures that require at least one dispensing event to be calculated. Measurement strategies that require a second dispensing event evidence even greater upward bias. These biases are greatest with shorter observation times. Furthermore, requiring a dispensing to be calculated meant that these measures could not be defined for large numbers of individuals (17-32 % of participants in this study). Measurement strategies that do not require a dispensing event to be calculated appear least vulnerable to these biases and can be calculated for everyone. However they do require additional assumptions and data (e.g., pre-intervention dispensing data) to support their validity. CONCLUSIONS:Many adherence measures require one, or sometimes two, dispensings in order to be defined. Since such measures assume all dispensed medication is used as directed, they have a built in upward bias that is especially pronounced when they are calculated over relatively short timeframes (< 9 months). Less biased measurement strategies that do not require a dispensing event are available, but require additional data to support their validity. TRIAL REGISTRATION:The study was funded by grant R01HL83433 from the National Heart, Lung and Blood Institute (NHLBI) and is filed as study NCT00414817 in the clinicaltrials.gov database.

journal_name

BMC Health Serv Res

authors

Vollmer WM,Xu M,Feldstein A,Smith D,Waterbury A,Rand C

doi

10.1186/1472-6963-12-155

subject

Has Abstract

pub_date

2012-06-12 00:00:00

pages

155

issn

1472-6963

pii

1472-6963-12-155

journal_volume

12

pub_type

杂志文章,随机对照试验
  • A governance model for integrated primary/secondary care for the health-reforming first world - results of a systematic review.

    abstract:BACKGROUND:Internationally, key health care reform elements rely on improved integration of care between the primary and secondary sectors. The objective of this systematic review is to synthesise the existing published literature on elements of current integrated primary/secondary health care. These elements and how t...

    journal_title:BMC health services research

    pub_type: 杂志文章,评审

    doi:10.1186/1472-6963-13-528

    authors: Nicholson C,Jackson C,Marley J

    更新日期:2013-12-20 00:00:00

  • Health system readiness for innovation scale-up: the experience of community-based distribution of injectable contraceptives in Nigeria.

    abstract:BACKGROUND:Following the successful pilot of the community-based distribution of injectable contraceptives (CBDIC) by community health extension workers (CHEWs) in Gombe, northern Nigeria in 2010, there was a policy decision to scale-up the innovation to other parts of the country. However, there is limited understandi...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/s12913-019-4786-6

    authors: Akinyemi O,Harris B,Kawonga M

    更新日期:2019-12-05 00:00:00

  • Making it work for me: beliefs about making a personal health record relevant and useable.

    abstract:BACKGROUND:A Personal Health Record (PHR) is an electronic record that individuals use to manage and share their health information, e.g. data from their medical records and data collected by apps. However, engagement with their record can be low if people do not find it beneficial to their health, wellbeing or interac...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/s12913-018-3254-z

    authors: Fylan F,Caveney L,Cartwright A,Fylan B

    更新日期:2018-06-14 00:00:00

  • Potential barriers and facilitators for implementation of an integrated care pathway for hearing-impaired persons: an exploratory survey among patients and professionals.

    abstract:BACKGROUND:Because of the increasing costs and anticipated shortage of Ear Nose and Throat (ENT) specialists in the care for hearing-impaired persons, an integrated care pathway that includes direct hearing aid provision was developed. While this direct pathway is still under investigation, in a survey we examined expe...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-7-57

    authors: Grutters JP,van der Horst F,Joore MA,Verschuure H,Dreschler WA,Anteunis LJ

    更新日期:2007-04-19 00:00:00

  • Chronology of prescribing error during the hospital stay and prediction of pharmacist's alerts overriding: a prospective analysis.

    abstract:BACKGROUND:Drug prescribing errors are frequent in the hospital setting and pharmacists play an important role in detection of these errors. The objectives of this study are (1) to describe the drug prescribing errors rate during the patient's stay, (2) to find which characteristics for a prescribing error are the most...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-10-13

    authors: Caruba T,Colombet I,Gillaizeau F,Bruni V,Korb V,Prognon P,Bégué D,Durieux P,Sabatier B

    更新日期:2010-01-12 00:00:00

  • Patient experiences and health system responsiveness in South Africa.

    abstract:BACKGROUND:Patients' views are being given more and more importance in policy-making. Understanding populations' perceptions of quality of care is critical to developing measures to increase the utilization of primary health care services. Using the data from the South African World Health Survey (WHS), the current stu...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-9-117

    authors: Peltzer K

    更新日期:2009-07-14 00:00:00

  • Predictors of dropout in the German disease management program for type 2 diabetes.

    abstract:BACKGROUND:To improve and assess the effectiveness of disease management programs (DMPs), it is critical to understand how many people drop out of disease management programs and why. METHODS:We used routine data provided by a statutory health insurance fund from the regions North Rhine, North Wurttemberg and Hesse. A...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-12-8

    authors: Fullerton B,Erler A,Pöhlmann B,Gerlach FM

    更新日期:2012-01-10 00:00:00

  • Improving utilization of and retention in PMTCT services: can behavioral economics help?

    abstract:BACKGROUND:The most recent strategic call to action of the World Health Organization sets the elimination of pediatric HIV as a goal. While recent efforts have focused on building infrastructure and ensuring access to high-quality treatment, we must now turn our focus to the behavior change needed to eliminate vertical...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-13-406

    authors: Taylor NK,Buttenheim AM

    更新日期:2013-10-10 00:00:00

  • Moderating effects of coping on work stress and job performance for nurses in tertiary hospitals: a cross-sectional survey in China.

    abstract:BACKGROUND:Work stress is a major problem for nurses and it can negatively influence job performance. Therefore, it is critical to explore variables that can reduce or buffer the negative effects of work stress. This study explores the moderating effects of coping strategies on the relationship between work stress and ...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/s12913-017-2348-3

    authors: Li L,Ai H,Gao L,Zhou H,Liu X,Zhang Z,Sun T,Fan L

    更新日期:2017-06-12 00:00:00

  • Through the professional's eyes: transfers of care during pregnancy, childbirth and the postpartum period.

    abstract:BACKGROUND:In the Netherlands, the obstetric and neonatal healthcare system consists of multiple healthcare organizations. Due to this system, transfers between healthcare professionals are inevitable. Transfers can interrupt the continuity of care, which is an important aspect of care quality. The aim of this study is...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/s12913-020-4941-0

    authors: van Stenus CMV,Poorthuis MB,Boere-Boonekamp MM,Need A

    更新日期:2020-02-11 00:00:00

  • Willingness to pay and willingness to accept in a patient-centered blood pressure control study.

    abstract:BACKGROUND:Elevated blood pressure is a major risk factor for cardiovascular disease and stroke but patients often discount recommended behavioral changes and prescribed medications. While effective interventions to promote adherence have been developed, cost-effectiveness from the patient's perspective, has not been w...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/s12913-017-2451-5

    authors: Gleason-Comstock J,Streater A,Goodman A,Janisse J,Brody A,Mango L,Dawood R,Levy P

    更新日期:2017-08-07 00:00:00

  • Optimising clinical effectiveness and quality along the atrial fibrillation anticoagulation pathway: an economic analysis.

    abstract:BACKGROUND:Atrial fibrillation (AF) represents the most common sustained cardiac arrhythmia. A service evaluation was carried out at an anticoagulation clinic in Newcastle upon-Tyne to explore the efficacy of introducing self-testing of anticoagulation status for AF patients on warfarin. The analysis presented aims to ...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/s12913-019-4841-3

    authors: Moloney E,Craig D,Holdsworth N,Smithson J

    更新日期:2019-12-28 00:00:00

  • Hospital choice in Germany from the patient's perspective: a cross-sectional study.

    abstract:BACKGROUND:In many countries health policy encourages patients to choose their hospital, preferably by considering information of performance reports. Previous studies on hospital choice mainly have focused on patients undergoing elective surgery. This study examined a representative sample of hospital inpatients acros...

    journal_title:BMC health services research

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12913-017-2712-3

    authors: de Cruppé W,Geraedts M

    更新日期:2017-11-13 00:00:00

  • A mixed methods contribution to the study of health public policies: complementarities and difficulties.

    abstract::The use of mixed methods (combining quantitative and qualitative data) is developing in a variety of forms, especially in the health field. Our own research has adopted this perspective from the outset. We have sought all along to innovate in various ways and especially to develop an equal partnership, in the sense of...

    journal_title:BMC health services research

    pub_type: 历史文章,杂志文章,评审

    doi:10.1186/1472-6963-15-S3-S7

    authors: Ridde V,Olivier de Sardan JP

    更新日期:2015-01-01 00:00:00

  • Effectiveness, cost effectiveness, acceptability and implementation barriers/enablers of chronic kidney disease management programs for Indigenous people in Australia, New Zealand and Canada: a systematic review of mixed evidence.

    abstract:BACKGROUND:Indigenous peoples in Australia, New Zealand and Canada carry a greater burden of chronic kidney disease (CKD) than the general populations in each country, and this burden is predicted to increase. Given the human and economic cost of dialysis, understanding how to better manage CKD at earlier stages of dis...

    journal_title:BMC health services research

    pub_type: 杂志文章,评审

    doi:10.1186/s12913-016-1363-0

    authors: Reilly R,Evans K,Gomersall J,Gorham G,Peters MD,Warren S,O'Shea R,Cass A,Brown A

    更新日期:2016-04-06 00:00:00

  • 'Choice, culture and confidence': key findings from the 2012 having a baby in Queensland Aboriginal and Torres Strait Islander survey.

    abstract:BACKGROUND:To describe the maternity care experiences of Aboriginal and/or Torres Strait Islander women in Queensland, Australia and to identify areas for policy and practice improvements. METHODS:A culturally-tailored survey requesting both quantitative and qualitative information was completed by respondents either ...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-14-196

    authors: Parker S,McKinnon L,Kruske S

    更新日期:2014-05-01 00:00:00

  • Developing attributes and attribute-levels for a discrete choice experiment on micro health insurance in rural Malawi.

    abstract:BACKGROUND:Discrete choice experiments (DCEs) are attribute-driven experimental techniques used to elicit stakeholders' preferences to support the design and implementation of policy interventions. The validity of a DCE, therefore, depends on the appropriate specification of the attributes and their levels. There have ...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-14-235

    authors: Abiiro GA,Leppert G,Mbera GB,Robyn PJ,De Allegri M

    更新日期:2014-05-22 00:00:00

  • Emergency department documentation templates: variability in template selection and association with physical examination and test ordering in dizziness presentations.

    abstract:BACKGROUND:Clinical documentation systems, such as templates, have been associated with process utilization. The T-System emergency department (ED) templates are widely used but lacking are analyses of the templates association with processes. This system is also unique because of the many different template options av...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-11-65

    authors: Kerber KA,Hofer TP,Meurer WJ,Fendrick AM,Morgenstern LB

    更新日期:2011-03-24 00:00:00

  • Physicians' use of the 5As in counseling obese patients: is the quality of counseling associated with patients' motivation and intention to lose weight?

    abstract:BACKGROUND:Physicians are encouraged to counsel obese patients to lose weight, but studies measuring the quality of physicians' counseling are rare. We sought to describe the quality of physicians' obesity counseling and to determine associations between the quality of counseling and obese patients' motivation and inte...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-10-159

    authors: Jay M,Gillespie C,Schlair S,Sherman S,Kalet A

    更新日期:2010-06-09 00:00:00

  • Differences in sickness absence between self-employed and employed doctors: a cross-sectional study on national sample of Norwegian doctors in 2010.

    abstract:BACKGROUND:Doctors have a low prevalence of sickness absence. Employment status is a determinant in the multifactorial background of sickness absence. The effect of doctors' employment status on sickness absence is unexplored. The study compares the number of sickness absence days during the last 12 months and the impa...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-14-199

    authors: Rosta J,Tellnes G,Aasland OG

    更新日期:2014-05-02 00:00:00

  • "I go I die, I stay I die, better to stay and die in my house": understanding the barriers to accessing health care in Timor-Leste.

    abstract:BACKGROUND:Despite public health care being free at the point of delivery in Timor-Leste, wealthier patients access hospital care at nearly twice the rate of poorer patients. This study seeks to understand the barriers driving inequitable utilisation of hospital services in Timor-Leste from the perspective of community...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/s12913-016-1762-2

    authors: Price JA,Soares AI,Asante AD,Martins JS,Williams K,Wiseman VL

    更新日期:2016-09-30 00:00:00

  • React and act: a qualitative study of how nursing home leaders follow up on staff-to-resident abuse.

    abstract:BACKGROUND:Elder abuse in nursing homes is a complex multifactorial problem and entails various associations across personal, social, and organisational factors. One way leaders can prevent abuse and promote quality and safety for residents is to follow up on any problems that may arise in clinical practice in a way th...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/s12913-020-05969-x

    authors: Myhre J,Saga S,Malmedal W,Ostaszkiewicz J,Nakrem S

    更新日期:2020-12-01 00:00:00

  • Trends and area variations in Potentially Preventable Admissions for COPD in Spain (2002-2013): a significant decline and convergence between areas.

    abstract:BACKGROUND:Potentially Preventable Hospitalizations (PPH) are hospital admissions for conditions which are preventable with timely and appropriate outpatient care being Chronic Obstructive Pulmonary Disease (COPD) admissions one of the most relevant PPH. We estimate the population age-sex standardized relative risk of ...

    journal_title:BMC health services research

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12913-016-1624-y

    authors: Librero J,Ibañez-Beroiz B,Peiró S,Ridao-López M,Rodríguez-Bernal CL,Gómez-Romero FJ,Bernal-Delgado E,Spanish Atlas of Medical Practice Variation Research Group.

    更新日期:2016-08-09 00:00:00

  • HIV disease burden, cost, and length of stay in Portuguese hospitals from 2000 to 2010: a cross-sectional study.

    abstract:BACKGROUND:The number of HIV-related hospitalizations has decreased worldwide in recent years owing to the availability of highly active antiretroviral therapy. However, the change in HIV-related hospitalizations in Portugal has not been studied. Using comprehensive hospital discharge data from mainland Portuguese hosp...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/s12913-015-0801-8

    authors: Catumbela E,Freitas A,Lopes F,Mendoza Mdel C,Costa C,Sarmento A,da Costa-Pereira A

    更新日期:2015-04-08 00:00:00

  • Doctors are to blame for perceived medical adverse events. A cross sectional population study. The Tromsø Study.

    abstract:BACKGROUND:Most current knowledge of the incidence of medical adverse events (AEs) comes from studies carried out in hospital settings. Little is known about AEs occurring outside hospitals, in spite the fact that most of contacts between patients and health care take place in primary care. Small sample population stud...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-13-46

    authors: Hotvedt R,Førde OH

    更新日期:2013-02-05 00:00:00

  • Effect of changed organisation of nutritional care of Danish medical inpatients.

    abstract:BACKGROUND:Many patients are undernourished during hospitalisation. The clinical consequences of this include lassitude, an increased risk of complications and prolonged convalescence. The aim of the study is 1) to implement a new organisation with a focus on improving the quality of the nutritional care of medical inp...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-8-168

    authors: Lassen KO,Grinderslev E,Nyholm R

    更新日期:2008-08-07 00:00:00

  • Exploring Aboriginal aged care residents' cultural and spiritual needs in South Australia.

    abstract:BACKGROUND:Attention to culture and its impact on health care can improve the quality of care given, add to our understanding of health care among culturally diverse populations, and encourage a more holistic approach to health care within general care. Connection to culture is important to Aboriginal peoples, and inte...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/s12913-019-4322-8

    authors: Sivertsen N,Harrington A,Hamiduzzaman M

    更新日期:2019-07-12 00:00:00

  • The distribution of maternity services across rural and remote Australia: does it reflect population need?

    abstract:BACKGROUND:Australia has a universal health care system and a comprehensive safety net. Despite this, outcomes for Australians living in rural and remote areas are worse than those living in cities. This study will examine the current state of equity of access to birthing services for women living in small communities ...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/s12913-017-2084-8

    authors: Rolfe MI,Donoghue DA,Longman JM,Pilcher J,Kildea S,Kruske S,Kornelsen J,Grzybowski S,Barclay L,Morgan GG

    更新日期:2017-02-23 00:00:00

  • Training providers: beyond the basics of electronic health records.

    abstract:BACKGROUND:Training is a critical part of health information technology implementations, but little emphasis is placed on post-implementation training to support day-to-day activities. The goal of this study was to evaluate the impact of post-implementation training on key electronic health record activities. METHODS:...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-13-503

    authors: Bredfeldt CE,Awad EB,Joseph K,Snyder MH

    更新日期:2013-12-02 00:00:00

  • Pay for performance: an analysis of the context of implementation in a pilot project in Tanzania.

    abstract:BACKGROUND:Pay for performance schemes are increasingly being implemented in low income countries to improve health service coverage and quality. This paper describes the context within which a pay for performance programme was introduced in Tanzania and discusses the potential for pay for performance to address health...

    journal_title:BMC health services research

    pub_type: 杂志文章

    doi:10.1186/1472-6963-14-392

    authors: Olafsdottir AE,Mayumana I,Mashasi I,Njau I,Mamdani M,Patouillard E,Binyaruka P,Abdulla S,Borghi J

    更新日期:2014-09-16 00:00:00