Comparison of the multigene panel test and OncoScan™ for the determination of HER2 amplification in breast cancer.

abstract：:Previously we demonstrated that protein coded by the BRCA1 gene was expressed in normal human buccal cells. The present study confirmed that BRCA2 protein was similarly expressed in these cells. Messenger RNA for BRCA2 was detected with sequential use of two primer sets. Pooled cell samples from healthy donors reacted...

journal_title：Oncology reports

authors： Byrne TJ,Cohn GM,Lane MA,Adams LA,Hoffman DE,Reece MT

更新日期：2000-09-01 00:00:00

abstract：:In order to elucidate the role of alpha-smooth muscle actin (ASMA)-positive stromal cells, namely myofibroblasts (MFs), in invasive growth of gastric carcinomas (GCs), we examined the number of MFs at the deep border (DB) of GCs. In total 78 invasive GCs (48 intestinal type GCs and 30 diffuse type GCs) were examined i...

journal_title：Oncology reports

authors： Nakayama H,Enzan H,Miyazaki E,Kuroda N,Naruse K,Kiyoku H,Hiroi M

更新日期：2000-09-01 00:00:00

abstract：:Wild-type p53 protein plays an important role in the cellular response to ionising radiation and other DNA damaging agents and is mutated in many human tumours. Immunohistochemistry is a rapid method to detect elevated protein levels. The p53 status in a group of patients treated by radiotherapy exclusively for oesoph...

journal_title：Oncology reports

authors： Pomp J,Blom J,Zwinderman AH,Van Krimpen C

更新日期：2000-09-01 00:00:00

abstract：:Five-hundred and twenty-six patients with non-metastatic osteosarcoma of the extremities treated at Istituto Ortopedico Rizzoli from 1983 to 1995 with neoadjuvant chemotherapy and limb salvage, were retrospectively studied to evaluate the rate of local and systemic control. At a mean follow-up of 9.5 years (3-17), 320...

journal_title：Oncology reports

authors： Bacci G,Ruggieri P,Bertoni F,Ferrari S,Longhi A,Biagini R,Zavatta M,Versari M,Forni C

更新日期：2000-09-01 00:00:00

abstract：:Sixteen ovarian germ-cell malignancy (OGCM) patients between 1983 and 1999 were randomly divided into the BEP group (n=6; bleomycin, etoposide and cisplatin) and the BAP group (n=10; bleomycin, actinomycin-D and cisplatin). The patients were evaluated for adverse drug reactions (ADRs) based on severity-grading of the ...

journal_title：Oncology reports

authors： Sumi T,Ishiko O,Yoshida H,Ogita S

更新日期：2000-11-01 00:00:00

abstract：:Angiogenesis, new blood vessels development, is an important process involved in ovarian cancer growth and metastasis. Adenosine is a known mediator of angiogenesis in hypoxic tissues. Theobromine, adenosine receptor antagonist, exerts antiangiogenic properties in many types of tumors in Balb/c mice cutaneous angiogen...

journal_title：Oncology reports

authors： Barcz E,Sommer E,Janik P,Marianowski L,Skopinska-Rózewska E

更新日期：2000-11-01 00:00:00

abstract：:A 20 year-old man was hospitalized with an abdominal mass and abdominal distension. Investigations resulted in a diagnosis of ileus caused by advanced colon cancer with peritoneal dissemination to the pouch of Douglas. Palliative surgery was performed to relieve bowel obstruction and debulk the tumor. Histopathologica...

journal_title：Oncology reports

authors： Mukai M,Tokunaga N,Yasuda S,Mukohyama S,Kameya T,Ishikawa K,Iwase H,Suzuki T,Ishida H,Sadahiro S,Makuuchi H

更新日期：2000-11-01 00:00:00

abstract：:There is accumulating evidence that cysteine proteinase activity plays an important role in cancer cell invasion and metastasis. Previously we demonstrated that cathepsin B (CB) plasma activity is increased in patients with transitional bladder cancer (TCC). In this work we have attempted to determine whether urine CB...

journal_title：Oncology reports

authors： Eiján AM,Sandes E,Puricelli L,Bal De Kier Joffé E,Casabé AR

更新日期：2000-11-01 00:00:00

abstract：:We used a thyroid metastatic tumor model to analyze some of the mechanisms of invasion and metastasis in culture. Chronic TSH stimulation (thyroid stimulating hormone) was associated with enhanced tumor proliferation and aggressiveness. We present a unique metastatic tumor model including three follicular thyroid canc...

journal_title：Oncology reports

authors： Hoelting T,Goretzki PE,Duh QY

更新日期：2001-01-01 00:00:00

abstract：:A 43-year old woman, operated on for ovarian clear cell carcinoma (stage IIc) four years previously was found to have a small mass under the abdominal wall in the right lower quadrant of the abdomen. Neither diagnostic imaging (ultrasonography and MRI) nor tumor markers showed any evidence of recurrence, but positron ...

journal_title：Oncology reports

authors： Ishiko O,Honda K,Hirai K,Sumi T,Ogita S,Koyama K,Kawabe J,Ochi H

更新日期：2001-01-01 00:00:00

abstract：:Reverse transcription polymerase chain reaction (RT-PCR)-based detection of tyrosinase mRNA is a frequently used method for the identification of circulating tumor cells in melanoma patients. The significance and practical value of this procedure for the diagnosis of tumor dissemination in melanoma patients are unclea...

journal_title：Oncology reports

authors： Hasselmann DO,Rappl G,Rössler M,Ugurel S,Tilgen W,Reinhold U

更新日期：2001-01-01 00:00:00

abstract：:A 60-year old man presented with Horner's syndrome, and acute right hand and lower extremity weakness. Chest X-ray and MRI revealed a right apical lung tumor (presumed to be a primary lung cancer), with brachial plexus infiltration and spinal cord compression. Emergent radiotherapy was initiated for spinal cord compre...

journal_title：Oncology reports

authors： Rao RD,Robins HI

更新日期：2001-01-01 00:00:00

abstract：:Immunological effector mechanisms of monoclonal antibodies such as antibody-dependent cytotoxicity can be augmented by the cytokines granulocyte-macrophage colony-stimulating factor (GM-CSF) or interleukin-2 (IL-2). Therefore twelve patients with metastatic colorectal cancer were treated with 300 microg GM-CSF and 6 m...

journal_title：Oncology reports

authors： Fiedler W,Krüger W,Laack E,Mende T,Vohwinkel G,Hossfeld DK

更新日期：2001-03-01 00:00:00

abstract：:Combination chemotherapy with paclitaxel and platinum is the most effective regimen for advanced ovarian cancer. Second-line chemotherapy with paclitaxel (135 mg/m2, 24 h) and carboplatin (AUC 5-6) is also effective for patients who relapse on the same regimen after 6 months or more. However, it has been shown that th...

journal_title：Oncology reports

authors： Adachi S,Ogasawara T,Ito K,Koyama M,Nagano T,Suzuki A,Yamada T,Nakata Y,Ozawa M

更新日期：2001-03-01 00:00:00

abstract：:The helpfulness of 18F-2-deoxyglucose positron emission tomography (FDG-PET) in restaging non-small cell lung cancer (NSCLC) has not been extensively evaluated. A total of 156 patients referred for restaging of NSCLC were retrospectively evaluated. According to the classification of American Joint Committee on Cancer,...

journal_title：Oncology reports

authors： Changlai SP,Tsai SC,Chou MC,Ho YJ,Kao CH

更新日期：2001-03-01 00:00:00

abstract：:The expression of LewisY related carbohydrate antigens and the content of epidermal growth factor receptor (EGF-R), the carcinoembryonic antigen (CEA) and the alpha-fetoprotein (AFP) in colorectal and liver tumors were determined. These included 30 large bowel adenocarcinomas (7 colon, 6 sigma, 5 caecum, 12 rectum), 1...

journal_title：Oncology reports

authors： Di Carlo A,Mariano A,D'Alessandro V,Belli G,Romano G,Macchia V

更新日期：2001-03-01 00:00:00

abstract：:Institutions that treat patients with lymphoma must know their local therapy results and adapt their treatment strategies accordingly. To allow the application of the international prognostic factor index (IPI) in institutions where some of the data necessary are not available, we devised an approach by which the miss...

journal_title：Oncology reports

authors： Biasoli I,Morais JC,Soares de Jesus P,Pulcheri W,Nucci M,Spector N

更新日期：2001-03-01 00:00:00

abstract：:There has been few reports describing that the prognostic significance of p53 alteration in colorectal tumors depended on the site of origin. Therefore, in this study, we examined whether there is a valid association between the p53 alterations and the prognosis of colorectal cancer patients, especially distal colorec...

journal_title：Oncology reports

authors： Okubo R,Masuda H,Nemoto N

更新日期：2001-05-01 00:00:00

abstract：:Although the alternative splicing of various genes is a common phenomenon in tumorigenesis, little is known about the mechanism behind it. Recently, we found altered expression of splicing regulatory factors during two-step chemical transformation in vitro. However, it remains unknown whether such altered expression o...

journal_title：Oncology reports

authors： Maeda T,Furukawa S

更新日期：2001-05-01 00:00:00

abstract：:5-fluorouracil (5-FU) is a widely used chemotherapeutic agent for various carcinomas. However, the therapeutic effect of 5-FU differs among patients. The differences in the effectiveness of 5-FU are thought to be based on the different enzymatic activity which inactivates 5-FU of the host tissue. 5-FU is catabolized t...

journal_title：Oncology reports

authors： Ikeguchi M,Hirooka Y,Makino M,Kaibara N

更新日期：2001-05-01 00:00:00

abstract：:Cancer cells express particular genes, part of which are normally active during the embryonic development. On the other hand, young embryos are able to differentiate teratocarcinoma or leukemia cells, likely by producing differentiation factors. In this work, rat and mouse embryo cell nuclei extracts were tested on he...

journal_title：Oncology reports

authors： Berger G,Frayssinet C,Berger M,Lafarge Frayssinet C

更新日期：2001-05-01 00:00:00

abstract：:Retroperitoneal tumors are occasionally encountered by gynecologists, and differential diagnosis from adnexal tumors is important, however, it is difficult in many cases. We report a case in which we preoperatively diagnosed a benign solid tumor in the retroperitoneum of the pelvic cavity on the basis of a variety of ...

journal_title：Oncology reports

authors： Hirai K,Umesaki N,Sumi T,Ishiko O,Kanaoka Y,Ogita S,Koyama K,Kawabe J,Okamura T,Ochi H

更新日期：2001-07-01 00:00:00

abstract：:Recently, we reported that cycloprodigiosin hydrochloride (cPrG.HCl), a novel H+/Cl- symporter, induces acidification of the cytosol and leads to apoptosis on rat and human liver cancer cells. In the present study, the effects of cPrG.HCl, a H+/Cl- symporter, were examined in colon cancer cell lines in vitro. In the M...

journal_title：Oncology reports

authors： Yamamoto C,Takemoto H,Kuno K,Yamamoto D,Nakai K,Baden T,Kamata K,Hirata H,Watanabe T,Inoue K

更新日期：2001-07-01 00:00:00

abstract：:Platelet-derived endothelial cell growth factor (PD-ECGF), identical to thymidine phosphorylase, has been reported as an angiogenic factor in human malignancies. However, the role of PD-ECGF in human hepatocellular carcinoma (HCC) is still unconfirmed. Herein, we studied the expression of PD-ECGF in 27 human HCC cases...

journal_title：Oncology reports

authors： Guo L,Kuroda N,Toi M,Miyazaki E,Hayashi Y,Enzan H,Jin Y

更新日期：2001-07-01 00:00:00

abstract：:Mutations in exons 4-8 of the p53 gene by the PCR-SSCP analysis in preneoplastic and neoplastic lesions of the colon (n=11) and esophagus (n=18) were screened. p53 overexpression by immunohistochemistry in 11 colonic lesions and 13 microsatellites, in all the patients (n=29), were also studied. A positive result conco...

journal_title：Oncology reports

authors： Copelli SB,Mazzeo C,Gimenez A,Casco C,Meiss R,Rubio H,Speroni A,Vanzulli S

更新日期：2001-07-01 00:00:00

abstract：:Nerve growth factor (NGF) is a member of the neurotrophin family and is essential for the differentiation and maintenance of neural cells. Recently, it has been reported that NGF is involved in the growth of breast cancer. On the other hand, two types of NGF receptors have been identified, a low-affinity receptor, p75...

journal_title：Oncology reports

authors： Sakamoto Y,Kitajima Y,Edakuni G,Hamamoto T,Miyazaki K

更新日期：2001-09-01 00:00:00

abstract：:Surgical treatment is usually selected for placental polyp accompanied by massive bleeding but patients wishing to conserve their fecundity require conservative management. A 35-year old nullipara was diagnosed as having placental polyp on the basis of typical episodes, and detection of placental polypeptide hormones ...

journal_title：Oncology reports

authors： Yamamasu S,Nakai Y,Nishio J,Hyun Y,Honda KI,Hirai K,Ishiko O,Ogita S

更新日期：2001-09-01 00:00:00

abstract：:DNA methyltransferase and DNA demethylase are enzymes potentially affecting promoter methylation status. We examined levels of DNA methyltransferase (DNMT1, DNMT3a, DNMT3b) and DNA demethylase (MBD2) mRNA expression by semi-quantitative RT-PCR. In addition, we examined promoter methylation status of hMLH1, p16(INK4a),...

journal_title：Oncology reports

authors： Oue N,Kuraoka K,Kuniyasu H,Yokozaki H,Wakikawa A,Matsusaki K,Yasui W

更新日期：2001-09-01 00:00:00

abstract：:The cytologic findings of the tumor cells characteristic of the stages of thymomas were investigated to assess the invasiveness of the tumors. Forty-six patients with thymoma who underwent extensive thymectomy without pre-operative corticosteroid therapy were included in this study. The histologic subtypes included 18...

journal_title：Oncology reports

authors： Baba M,Nomoto Y,Iyoda A,Saito H,Hiroshima K,Shibuya K,Haga Y,Hoshino H,Iizasa T,Horiuchi F,Fujisawa T

更新日期：2001-09-01 00:00:00

abstract：:While papillary serous adenocarcinomas are histocytologically common in primary peritoneal carcinomas, clear cell carcinomas are rare. We report a new regimen for the treatment of recurrent clear cell carcinomas of the peritoneum. A 45-year-old woman was referred to our hospital and underwent optimal debulking surgery...

journal_title：Oncology reports

authors： Ichimura T,Ishiko O,Nishimura S,Kojima T,Shimura K

更新日期：2001-11-01 00:00:00