Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A.

abstract：:A naturally occurring subpopulation of human peripheral blood lymphocytes is cytotoxic to autologous and/or allogeneic fibroblasts. The autocytotoxic lymphocytes have a receptor for the third component of complement and for aggregated gamma globulin, do not form rosettes with sheep red blood cells, and are not removed...

journal_title：The Journal of experimental medicine

authors： Parkman R,Rosen FS

更新日期：1976-12-01 00:00:00

abstract：:Contact hypersensitivity (CHS) is a T cell-mediated skin inflammation induced by epicutaneous exposure to haptens in sensitized individuals. We have previously reported that CHS to dinitrofluorobenzene in mice is mediated by major histocompatibility complex (MHC) class I-restricted CD8(+) T cells. In this study, we sh...

journal_title：The Journal of experimental medicine

authors： Kehren J,Desvignes C,Krasteva M,Ducluzeau MT,Assossou O,Horand F,Hahne M,Kägi D,Kaiserlian D,Nicolas JF

更新日期：1999-03-01 00:00:00

abstract：:In this study we used TEPITOPE, a new epitope prediction software, to identify sequence segments on the MAGE-3 protein with promiscuous binding to histocompatibility leukocyte antigen (HLA)-DR molecules. Synthetic peptides corresponding to the identified sequences were synthesized and used to propagate CD4(+) T cells ...

journal_title：The Journal of experimental medicine

authors： Manici S,Sturniolo T,Imro MA,Hammer J,Sinigaglia F,Noppen C,Spagnoli G,Mazzi B,Bellone M,Dellabona P,Protti MP

更新日期：1999-03-01 00:00:00

abstract：:Data presented in this paper suggest that there may be two alternative pathways which T lymphocytes can use in generating a cytotoxic response to alloantigens in vitro. First, there is the pathway taken when stimulator and responder cells differ by an entire H-2 complex where Ly1+2- helper T lymphocytes respond to I r...

journal_title：The Journal of experimental medicine

authors： Bach FH,Alter BJ

更新日期：1978-09-01 00:00:00

abstract：:In extravasation of T cells, little is known about the mechanisms of transendothelial migration subsequent to the T cells' tight adhesion to endothelium. To investigate these mechanisms, we developed a monoclonal antibody (mAb), termed anti-4C8, that blocks transmigration but not adhesion in a culture system in which ...

journal_title：The Journal of experimental medicine

authors： Masuyama J,Yoshio T,Suzuki K,Kitagawa S,Iwamoto M,Kamimura T,Hirata D,Takeda A,Kano S,Minota S

更新日期：1999-03-15 00:00:00

abstract：:In hepatocellular carcinoma (HCC), autoantibodies to intracellular antigens are detected in 30-40% of patients. Patients with chronic hepatitis or liver cirrhosis develop HCC, and when this occurs, some patients exhibit autoantibodies of new specificities. It has been suggested that these novel autoantibody responses ...

journal_title：The Journal of experimental medicine

authors： Zhang JY,Chan EK,Peng XX,Tan EM

更新日期：1999-04-05 00:00:00

abstract：:Propagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules. SH2 domain-containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor Vav to activate the nuclear factor of activated cells (NF-AT), and its expression is required for normal T cell developme...

journal_title：The Journal of experimental medicine

authors： Law CL,Ewings MK,Chaudhary PM,Solow SA,Yun TJ,Marshall AJ,Hood L,Clark EA

更新日期：1999-04-19 00:00:00

abstract：:CD4(+) and CD8(+) T cells exhibit important differences in their major effector functions. CD8(+) T cells provide protection against pathogens through cytolytic activity, whereas CD4(+) T cells exert important regulatory activity through production of cytokines. However, both lineages can produce interferon (IFN)-gamm...

journal_title：The Journal of experimental medicine

authors： Carter LL,Murphy KM

更新日期：1999-04-19 00:00:00

abstract：:The activity of interleukin (IL)-9 on B cells was analyzed in vivo using transgenic mice that constitutively express this cytokine. These mice show an increase in both baseline and antigen-specific immunoglobulin concentrations for all isotypes tested. Analysis of B cell populations showed a specific expansion of Mac-...

journal_title：The Journal of experimental medicine

authors： Vink A,Warnier G,Brombacher F,Renauld JC

更新日期：1999-05-03 00:00:00

abstract：:A panel of cDNAs encoding allergenic proteins was isolated from an Aspergillus fumigatus cDNA library displayed on the surface of filamentous phage. Solid phase-immobilized serum immunoglobulin E (IgE) from A. fumigatus-allergic individuals was used to enrich phage displaying IgE-binding molecules. One of the cDNAs en...

journal_title：The Journal of experimental medicine

authors： Mayer C,Appenzeller U,Seelbach H,Achatz G,Oberkofler H,Breitenbach M,Blaser K,Crameri R

更新日期：1999-05-03 00:00:00

abstract：:To study the histocompatibility restriction between macrophages and helper T cells, carrier primed guinea pig T cells were positively selected in vitro with antigenpulsed macrophages for 7 days and the selected T cells were then mixed with hapten-primed B cells and stimulated with antigen in a modified Mishell-Dutton ...

journal_title：The Journal of experimental medicine

authors： Yamashita U,Shevach EM

更新日期：1978-11-01 00:00:00

abstract：:Incubation of normal or thioglycollate-elicited mouse peritoneal macrophages with 2-deoxy-D-glucose (2-dG) inhibits the capacity of these macrophages to phagocytize IgG- or complement-coated particles via their Fc and C3 receptors. 2-dG has no inhibitory effect on the capacity of these macrophages to phagocytize latex...

journal_title：The Journal of experimental medicine

authors： Michl J,Ohlbaum DJ,Silverstein SC

更新日期：1976-12-01 00:00:00

abstract：:The question of whether enhanced memory T cell responses are simply due to an increased frequency of specific cells or also to an improved response at the single cell level is widely debated. In this study, we analyzed T cell receptor (TCR) transgenic memory T cells and bona fide memory T cells isolated from virally i...

journal_title：The Journal of experimental medicine

authors： Bachmann MF,Gallimore A,Linkert S,Cerundolo V,Lanzavecchia A,Kopf M,Viola A

更新日期：1999-05-17 00:00:00

abstract：:Asthma is a chronic disease characterized by increased airway responsiveness and airway inflammation. The functional role of nitric oxide (NO) and the various nitric oxide synthase (NOS) isoforms in human asthma is controversial. To investigate the role of NO in an established model of allergic asthma, mice with targe...

journal_title：The Journal of experimental medicine

authors： De Sanctis GT,MacLean JA,Hamada K,Mehta S,Scott JA,Jiao A,Yandava CN,Kobzik L,Wolyniec WW,Fabian AJ,Venugopal CS,Grasemann H,Huang PL,Drazen JM

更新日期：1999-05-17 00:00:00

abstract：:B-1 lymphocytes represent a distinct B cell subset with characteristic features that include self-renewing capacity and unusual mitogenic responses. B-1 cells differ from conventional B cells in terms of the consequences of phorbol ester treatment: B-1 cells rapidly enter S phase in response to phorbol ester alone, wh...

journal_title：The Journal of experimental medicine

authors： Tanguay DA,Colarusso TP,Pavlovic S,Irigoyen M,Howard RG,Bartek J,Chiles TC,Rothstein TL

更新日期：1999-06-07 00:00:00

abstract：:Toll-like receptor 4 (TLR4) is a mammalian homologue of Drosophila Toll, a leucine-rich repeat molecule that can trigger innate responses against pathogens. The TLR4 gene has recently been shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (LPS). TLR4 may be a ...

journal_title：The Journal of experimental medicine

authors： Shimazu R,Akashi S,Ogata H,Nagai Y,Fukudome K,Miyake K,Kimoto M

更新日期：1999-06-07 00:00:00

abstract：:This study investigated the role of natural killer (NK) cells as effectors of an immune response against autologous cells modified by gene therapy. T lymphocytes were transduced with LXSN, a retroviral vector adopted for human gene therapy that carries the selectable marker gene neo, and the autologous NK response was...

journal_title：The Journal of experimental medicine

authors： Liberatore C,Capanni M,Albi N,Volpi I,Urbani E,Ruggeri L,Mencarelli A,Grignani F,Velardi A

更新日期：1999-06-21 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) is a potentially immunosuppressive agent that may act as a cofactor in the progression of AIDS. Here, we describe the first small animal model of HHV-6 infection. HHV-6 subgroup A, strain GS, efficiently infected the human thymic tissue implanted in SCID-hu Thy/Liv mice, leading to the dest...

journal_title：The Journal of experimental medicine

authors： Gobbi A,Stoddart CA,Malnati MS,Locatelli G,Santoro F,Abbey NW,Bare C,Linquist-Stepps V,Moreno MB,Herndier BG,Lusso P,McCune JM

更新日期：1999-06-21 00:00:00

abstract：:Repeated attempts to show that costimulation for negative selection is controlled by a single cell surface molecule have been unsuccessful. Thus, negative selection may involve multiple cell surface molecules acting in consort. In support of this idea, we show here that at least three cell surface molecules, namely CD...

journal_title：The Journal of experimental medicine

authors： Kishimoto H,Sprent J

更新日期：1999-07-05 00:00:00

abstract：:Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair pathway is involved in antibody class switch recombination. Splenic B cells from mice deficient in Msh2, Mlh1, Pms2, or Mlh1 and Pms2 were stimulated in culture with lipopolysaccharide (LPS) to induce immunoglobulin ...

journal_title：The Journal of experimental medicine

authors： Schrader CE,Edelmann W,Kucherlapati R,Stavnezer J

更新日期：1999-08-02 00:00:00

abstract：:Until now, it has been unclear whether murine cytomegalovirus (MCMV)-encoded protein m144 directly regulates natural killer (NK) cell effector function and whether the effects of m144 are only strictly evident in the context of MCMV infection. We have generated clones of the transporter associated with antigen process...

journal_title：The Journal of experimental medicine

authors： Cretney E,Degli-Esposti MA,Densley EH,Farrell HE,Davis-Poynter NJ,Smyth MJ

更新日期：1999-08-02 00:00:00

abstract：:Cytomegalovirus (CMV) is generally described as a slowly replicating virus. During studies of immunocompromised patients, we observed rapid changes in the quantity of CMV DNA present in serial blood samples by quantitative-competitive polymerase chain reaction commensurate with a doubling time of <2 d. To further inve...

journal_title：The Journal of experimental medicine

authors： Emery VC,Cope AV,Bowen EF,Gor D,Griffiths PD

更新日期：1999-07-19 00:00:00

abstract：:We demonstrated previously that a single injection of recombinant human macrophage colony-stimulating factor (rhM-CSF) is sufficient for osteoclast recruitment and survival in osteopetrotic (op/op) mice with a deficiency in osteoclasts resulting from a mutation in M-CSF gene. In this study, we show that a single injec...

journal_title：The Journal of experimental medicine

authors： Niida S,Kaku M,Amano H,Yoshida H,Kataoka H,Nishikawa S,Tanne K,Maeda N,Nishikawa S,Kodama H

更新日期：1999-07-19 00:00:00

abstract：:Severe congenital neutropenia (SCN) is a heterogeneous condition characterized by a drastic reduction in circulating neutrophils and a maturation arrest of myeloid progenitor cells in the bone marrow. Usually this condition can be successfully treated with granulocyte colony-stimulating factor (G-CSF). Here we describ...

journal_title：The Journal of experimental medicine

authors： Ward AC,van Aesch YM,Gits J,Schelen AM,de Koning JP,van Leeuwen D,Freedman MH,Touw IP

更新日期：1999-08-16 00:00:00

abstract：:Transgenic expression constructs were employed to identify a cis-acting transcription element in the T cell receptor (TCR)-gamma locus, called HsA, between the Vgamma5 and Vgamma2 genes. In constructs lacking the previously defined enhancer (3'E(Cgamma1)), HsA supports transcription in mature but not immature T cells ...

journal_title：The Journal of experimental medicine

authors： Baker JE,Kang J,Xiong N,Chen T,Cado D,Raulet DH

更新日期：1999-09-06 00:00:00

abstract：:A simian homologue of Kaposi's sarcoma-associated herpesvirus (KSHV), the eighth human herpesvirus (HHV8), was isolated from a simian immunodeficiency virus (SIV)-infected rhesus macaque (Macaca mulatta) that developed a multicentric lymphoproliferative disorder (LPD). This simian rhadinovirus is genetically similar t...

journal_title：The Journal of experimental medicine

authors： Wong SW,Bergquam EP,Swanson RM,Lee FW,Shiigi SM,Avery NA,Fanton JW,Axthelm MK

更新日期：1999-09-20 00:00:00

abstract：:Mucosal surfaces are protected specifically by secretory immunoglobulin A (SIgA) and SIgM generated through external translocation of locally produced dimeric IgA and pentameric IgM. Their active transport is mediated by the epithelial polymeric Ig receptor (pIgR), also called the transmembrane secretory component. Pa...

journal_title：The Journal of experimental medicine

authors： Johansen FE,Pekna M,Norderhaug IN,Haneberg B,Hietala MA,Krajci P,Betsholtz C,Brandtzaeg P

更新日期：1999-10-04 00:00:00

abstract：:Development of effectors from naive CD4 cells occurs in two stages. The early stage involves activation and limited proliferation in response to T cell receptor (TCR) stimulation by antigen and costimulatory antigen presenting cells, whereas the later stage involves proliferation and differentiation in response to gro...

journal_title：The Journal of experimental medicine

authors： Haynes L,Linton PJ,Eaton SM,Tonkonogy SL,Swain SL

更新日期：1999-10-04 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease resulting from apoptotic destruction of beta cells in the islets of Langerhans. Low expression of antioxidants and a predilection to produce nitric oxide (NO) have been shown to underscore beta cell apoptosis. With this perspective in mind, we questio...

journal_title：The Journal of experimental medicine

authors： Grey ST,Arvelo MB,Hasenkamp W,Bach FH,Ferran C

更新日期：1999-10-18 00:00:00

abstract：:Optimal T cell differentiation into effector cells with specialized functions requires the participation of cytokine receptor signals. In T helper cells, this process is controlled by chromatin changes and distal and proximal regulatory elements as well as specific transcription factors. Analogous events during cytoto...

journal_title：The Journal of experimental medicine

authors： Zhang J,Scordi I,Smyth MJ,Lichtenheld MG

更新日期：1999-11-01 00:00:00