Glutamate receptor, ionotropic, N‑methyl D‑aspartate‑associated protein 1 promotes colorectal cancer cell proliferation and metastasis, and is negatively regulated by miR‑296‑3p.

abstract：:Oral tongue cancer is characterized by a high degree of local invasion and a high rate of metastasis to the cervical lymph nodes. Treatment options for this cancer are limited. However, gene therapy has attracted keen interest as a new strategy for refractory cancer. The aim of this study was to examine the efficiency...

journal_title：Molecular medicine reports

authors： Supriatno,Yuletnawati SE,Widiasto A

更新日期：2011-01-01 00:00:00

abstract：:Placental choriocarcinoma is a highly malignant tumor of the female reproductive organs. Even with chemotherapy, placental choriocarcinoma has a 20% mortality rate due to its indistinct pathogenesis and the absence of efficient therapeutic methods for this cancer. Wnt proteins and Wnt signaling are involved in a varie...

journal_title：Molecular medicine reports

authors： Peng S,Zhang J,Chen J,Wang H

更新日期：2011-01-01 00:00:00

abstract：:To study the role of indoleamine 2,3-dioxygenase (IDO) in immune response and immune escape in gastric cancer, the human IDO gene was cloned by reverse transcription-polymerase chain reaction (RT-PCR) and inserted into the pIRES2-EGFP vector to construct the IDO expression vector (pIRES2-EGFP-IDO). BGC-823 cells were ...

journal_title：Molecular medicine reports

authors： Zhang R,Li H,Yu J,Zhao J,Wang X,Wang G,Yao Z,Wei F,Xue Q,Ren X

更新日期：2011-01-01 00:00:00

abstract：:1403P-3 is a novel anthracenedione derivative isolated from the secondary metabolites of endophytic fungus from the South China Sea. In previous studies, 1403P-3 was found to exhibit potent cytotoxicity against human cancer cells, but its molecular target and the mechanisms mediating its cytotoxicity remain unknown. I...

journal_title：Molecular medicine reports

authors： Yuan J,He Z,Wu J,Lin Y,Zhu X

更新日期：2011-03-01 00:00:00

abstract：:Recent studies have indicated that progesterone (PROG) reduces the expression of inflammatory factors in brain tissue. The present study was designed to investigate whether PROG inhibits the inflammatory response and the infiltration of inflammatory cells in the brain. One hundred and seventy-six adult male Sprague-Da...

journal_title：Molecular medicine reports

authors： Wang J,Zhao Y,Liu C,Jiang C,Zhao C,Zhu Z

更新日期：2011-03-01 00:00:00

abstract：:Abnormal expression of let-7a microRNA (miRNA) in non-small cell lung cancer (NSCLC) cells and tissue has been previously reported. Our objective was to investigate whether let-7a miRNA is aberrantly expressed in the blood of NSCLC patients. Using real-time PCR (RT-PCR), we analyzed let-7a miRNA in archived whole bloo...

journal_title：Molecular medicine reports

authors： Jeong HC,Kim EK,Lee JH,Lee JM,Yoo HN,Kim JK

更新日期：2011-03-01 00:00:00

abstract：:The aim of this study was to provide a methodology to make a clear distinction between malignant tumors and morphologically similar benign processes, by examining the expression of EGFR, VEGF, HIF1-α, survivin, Bcl-2 and p53 proteins. Four groups of patient samples were studied: group 1, low-grade astrocytomas (WHO gr...

journal_title：Molecular medicine reports

authors： Medina Villaamil V,Alvarez García A,Aparicio Gallego G,Díaz Prado S,Rivas López LA,Santamarina Caínzos I,Valladares Ayerbes M,Antón Aparicio LM

更新日期：2011-05-01 00:00:00

abstract：:The aim of this study was to investigate whether the early endosome antigen 1 (EEA1) and/or PI3K pathway is involved in the molecular mechanisms underlying the effects of the six-transmembrane protein of prostate 4 (STEAP4; also called STAMP2 and TIARP) on the insulin sensitivity of human adipocytes. Our data demonstr...

journal_title：Molecular medicine reports

authors： Cheng R,Qiu J,Zhou XY,Chen XH,Zhu C,Qin DN,Wang JW,Ni YH,Ji CB,Guo XR

更新日期：2011-05-01 00:00:00

abstract：:Hemoglobin (Hb) Ottawa [α15 (A13) Gly→Arg], also known as Hb Siam, was first described in an 82-year-old Canadian in 1974. The same year, a second case was reported in a 28-year-old Chinese male living in Thailand. A third case was found in 1986 in a Chinese female living in the Hubei province of China. Since then, th...

journal_title：Molecular medicine reports

authors： Huang Y,Lin M,Lin CP,Wu JR,Zheng LH,Yang LY

更新日期：2011-05-01 00:00:00

abstract：:Sann-Joong-Kuey-Jian-Tang (SJKJT), a traditional Chinese medicine prescription, has been used to treat lymph node diseases and tumors. However, the molecular mechanisms of SJKJT in human colon cancer in vivo and in vitro have not been clearly elucidated. In the present study, we investigated the molecular mechanisms o...

journal_title：Molecular medicine reports

authors： Cheng CY,Lin YH,Su CC

更新日期：2010-01-01 00:00:00

abstract：:Several members of the ribonuclease superfamily possess a variety of interesting biological properties, including ribonucleolytic, angiogenic, antiproliferative, cytotoxic, embryotoxic, aspermatogenic and antitumoral activity. In this study, we report the purification from bovine milk of a protein with structural and ...

journal_title：Molecular medicine reports

authors： Di Liddo R,Dalzoppo D,Baiguera S,Conconi MT,Dettin M,Parnigotto PP,Grandi C

更新日期：2010-01-01 00:00:00

abstract：:Insulin receptor substrates (IRS)-5 and -6 are two recently identified members of the IRS family. We investigated their roles as insulin receptor substrates and compared them with Src-homology-2-containing (Shc) protein, a well-established substrate. Bioluminescence resonance energy transfer (BRET) experiments showed ...

journal_title：Molecular medicine reports

authors： Versteyhe S,Blanquart C,Hampe C,Mahmood S,Christeff N,De Meyts P,Gray SG,Issad T

更新日期：2010-01-01 00:00:00

abstract：:This study was undertaken to investigate the immunoexpression of Bcl-2 family proteins (Bcl-2, Bcl-x, Bax, Bak and Bad) and to evaluate the correlation between the immunoexpression of these proteins and that of cleaved caspase 3, Ki-67 and p53. A tissue microarray (TMA) paraffin block was constructed using gastric car...

journal_title：Molecular medicine reports

authors： Barrezueta LF,Oshima CT,Lima FO,De Oliveira Costa H,Gomes TS,Neto RA,De Franco MF

更新日期：2010-03-01 00:00:00

abstract：:This study describes the symmetric synthesis of novel β-lactams derived from chrysene directed towards their SAR, as well as their biological activities against several cancer cell lines in vitro. To our knowledge, this is the first report on the synthesis and biological evaluation of optically active anticancer β-lac...

journal_title：Molecular medicine reports

authors： Banik BK,Samajdar S,Becker FF

更新日期：2010-03-01 00:00:00

abstract：:microRNAs (miRNAs) are non-coding RNA transcripts thought to be instrumental in controlling eukaryotic cell function. This study aimed to identify miRNAs associated with the differential expression of estrogen receptor α (ERα) and progesterone receptor (PR) in uterine endometrial cancer. First, the pathology of Ishika...

journal_title：Molecular medicine reports

authors： Zhou J,Song T,Gong S,Zhong M,Su G

更新日期：2010-05-01 00:00:00

abstract：:Psychological stress is correlated with and may even cause DNA damage, which contributes to the etiology of various diseases. Recent studies point to the role of micro-RNA (miRNA), small molecules that regulate gene expression, in health and disease. This study investigated the relationship between transient stress an...

journal_title：Molecular medicine reports

authors： Gidron Y,De Zwaan M,Quint K,Ocker M

更新日期：2010-05-01 00:00:00

abstract：:Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene have been implicated in various diseases associated with cardiovascular risk factors, but little is known regarding the risks of ischemic stroke (IS) in patients with diabetes mellitus (DM). In this study, we evaluated the genotypes and haplotypes of t...

journal_title：Molecular medicine reports

authors： Kim OJ,Kim UK,Oh SH,Cho YW,Oh KI,Oh D,Park YS,Kim NK

更新日期：2010-05-01 00:00:00

abstract：:Mental retardation is correlated in approximately 0.4% of cases with the presence of a small supernumerary marker chromosome (sSMC). However, here we report a case of a carrier of a heterochromatic harmless sSMC with fragile X syndrome (Fra X). In approximately 2% of sSMC cases, similar heterochromatic sSMC were obser...

journal_title：Molecular medicine reports

authors： Nelle H,Schreyer I,Ewers E,Mrasek K,Kosyakova N,Merkas M,Hamid AB,Fahsold R,Ujfalusi A,Anderson J,Rubtsov N,Küchler A,von Eggeling F,Hentschel J,Weise A,Liehr T

更新日期：2010-07-01 00:00:00

abstract：:Adriamycin (ADM) is a drug used in the treatment of various types of cancer and exerts an antineoplastic effect mainly through the induction of apoptosis. Phosphoinositide 3 kinase (PI3K)/Akt and MAPK are fundamental survival pathways activated by exposure to most chemotherapeutical agents. However, the role of these ...

journal_title：Molecular medicine reports

authors： Zhou L,Luan H,Dong X,Li Y

更新日期：2010-07-01 00:00:00

abstract：:Stromal cell derived factor-1 (SDF-1), a CXC chemokine that plays an important role in the tumor growth, angiogenesis and metastasis of tumor cells, has a polymorphism at position 801 of its 3'-untranslated region, known as SDF1-3'A. The SDF1-3'A polymorphism has been investigated in various types of cancer, but no in...

journal_title：Molecular medicine reports

authors： Theodoropoulos GE,Panoussopoulos GS,Michalopoulos NV,Zambirinis CP,Taka S,Stamopoulos P,Gazouli M,Zografos G

更新日期：2010-07-01 00:00:00

abstract：:The progression and interrelationship of mediators that are released, activated or suppressed after major surgery appear to play an important role in responses to surgical stress. Heat shock protein 70 (HSP70) is stress-induced and acts like a cytokine to modulate pro-inflammatory mediators, such as tumor necrosis fac...

journal_title：Molecular medicine reports

authors： Suzuki S,Morimatsu H,Omori E,Shimizu H,Takahashi T,Yamatsuji T,Naomoto Y,Morita K

更新日期：2010-09-01 00:00:00

abstract：:20(S)-ginsenoside Rg3 [20(S)-Rg3)], one of the main constituents isolated from Panax ginseng, has been shown to have an anti-cancer effect and to induce apoptosis by interfering with several signaling pathways. However, the molecular mechanisms of AMP-activated protein kinase (AMPK) associated with apoptosis in HT-29 ...

journal_title：Molecular medicine reports

authors： Yuan HD,Quan HY,Zhang Y,Kim SH,Chung SH

更新日期：2010-09-01 00:00:00

abstract：:Livin, a member of the inhibitor of apoptosis protein family, is overexpressed in a variety of solid tumors and cancer cell lines. Livin overexpression has been reported in hepatocellular carcinoma (HCC), suggesting the biological significance of livin in HCC progression. However, the mechanisms of livin and the conse...

journal_title：Molecular medicine reports

authors： Liu H,Wang S,Sun H,Pan Z,Zhou W,Wu M

更新日期：2010-11-01 00:00:00

abstract：:The aim of the present study was to analyze the mRNA and protein expression of glioma-associated oncogene 1 (Gli1) in hepatocellular carcinoma (HCC) and its correlation with sonic hedgehog (Shh), one of the ligands of hedgehog (Hh) signaling, and two epithelial-mesenchymal transition (EMT) markers, E-cadherin and S100...

journal_title：Molecular medicine reports

authors： Zheng X,Yao Y,Xu Q,Tu K,Liu Q

更新日期：2010-11-01 00:00:00

abstract：:Versican is a large chondroitin sulfate proteoglycan produced by several tumor types, including malignant melanoma, which exists as four different splice variants. The large isoforms V0 and V1 promote melanoma cell proliferation. We previously described that overexpression of the short V3 isoform in MeWo human melanom...

journal_title：Molecular medicine reports

authors： Miquel-Serra L,Hernandez D,Docampo MJ,Bassols A

更新日期：2010-11-01 00:00:00

abstract：:Childhood spinal muscular atrophy (SMA) is an autosomal disorder caused by mutations in the survival motor neuron (SMN) gene. Although SMN is a ubiquitously expressed protein, mutations in SMN specifically cause the targeted deterioration of α-motor neurones of the spinal cord. This results in the progressive wasting ...

journal_title：Molecular medicine reports

authors： O'Hare E,Young PJ

更新日期：2009-01-01 00:00:00

abstract：:Copper and zinc are essential trace elements which play an important role in various biological processes. Along with various cytokines, glucocorticoids, glucagon and insulin, the acute-phase protein metallothionein is involved in the regulation of immune cell functions. Metallothionein is the central protein regulati...

journal_title：Molecular medicine reports

authors： Grüngreiff K,Hebell T,Gutensohn K,Reinhold A,Reinhold D

更新日期：2009-01-01 00:00:00

abstract：:Vascular endothelial growth factor receptor-2 or kinase insert domain-containing receptor (VEGFR2/KDR) is secreted by most solid tumors, including breast cancer, and is an important mediator of angiogenesis. To observe the effects of KDR gene expression on cell proliferation and the cell cycle in MCF-7 cells in vitro ...

journal_title：Molecular medicine reports

authors： Ge YL,Zhang JY,Zhang X,Hou L,Li Q,Xue ML

更新日期：2009-01-01 00:00:00

abstract：:This study aimed to clarify the mechanism by which apoptosis and Fas ligand (FasL) expression are induced in the ovarian granulosa cells of mice injected with irinotecan HCl (CPT-11). To this end, the direct effects of CPT-11 and its active metabolite, SN38, on granulosa cells were investigated. Normal ovarian tissue ...

journal_title：Molecular medicine reports

authors： Utsunomiya T,Tanaka T,Utsunomiya H,Umesaki N

更新日期：2009-03-01 00:00:00

abstract：:Metabolic syndrome (MS) is closely linked to a generalized metabolic disorder referred to as insulin resistance. Disturbances in the hemostasis and fibrinolytic systems are a feature of MS. The aim of this study was to determine the concentration levels of fibrinogen and plasminogen activator inhibitor-1 (PAI-1) in a ...

journal_title：Molecular medicine reports

authors： Palomo IG,Gutiérrez CL,Alarcón ML,Jaramillo JC,Segovia FM,Leiva EM,Mujica VE,Icaza GN,Díaz NS,Moore-Carrasco R

更新日期：2009-03-01 00:00:00