Abstract：
:The cochlea's inaccessibility and complex nature provide significant challenges to delivering drugs and other agents uniformly, safely and efficiently, along the entire cochlear spiral. Large drug concentration gradients are formed along the cochlea when drugs are administered to the middle ear. This undermines the major goal of attaining therapeutic drug concentration windows along the whole cochlea. Here, utilizing a well-known physiological effect of salicylate, we demonstrate a proof of concept in which drug distribution along the entire cochlea is enhanced by applying round window membrane low-frequency micro vibrations with a probe that only partially covers the round window. We provide evidence of enhanced drug influx into the cochlea and cochlear apical drug distribution without breaching cochlear boundaries. It is further suggested that ossicular functionality is not required for the effective drug distribution we report. The novel method presented here of local drug delivery to the cochlea could be implemented when ossicular functionality is absent or impeded and can be incorporated in clinically approved auditory protheses for patients who suffer with conductive, sensorineural or mixed hearing loss.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Flaherty SM,Russell IJ,Lukashkin ANdoi
10.1080/10717544.2021.1943059keywords:
["Inner ear drug delivery","acoustic streaming","assisted diffusion in straight pipes","cochlea","intratympanic administration","round window membrane"]subject
Has Abstractpub_date
2021-12-01 00:00:00pages
1312-1320issue
1eissn
1071-7544issn
1521-0464journal_volume
28pub_type
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