Abstract：
:Cellular viscosity is a prominent micro-environmental parameter and peroxynitrite is an essential reactive oxygen special, both of which are involved in various pathological and physiological processes. When the intracellular viscosity is abnormal or the ONOO- concentration is irregular, the normal function of cells will be disturbed. Herein, we rationally designed and synthesized a novel multichannel fluorescent probe (probe 1) for multichannel imaging of viscosity and peroxynitrite. Probe 1 displayed about 108-fold enhancement as the viscosity increased from 1.005 cP to 1090 cP. Moreover, the fluorescence intensity at 540 nm was quickly increased after adding ONOO-. It should be noted that probe 1 has high sensitivity, selectivity and low cytotoxicity, which can be successfully employed for the visualization of exogenous and endogenous ONOO- and imaging viscosity changes in HeLa cells by different fluorescent signals. Furthermore, probe 1 could monitor the change of ONOO- induced by LPS (lipopolysaccharide) and IFN-γ (interferon-γ) in zebrafish. This result reveals that probe 1 may inspire more diagnostic and therapeutic programs for viscosity-peroxynitrite related diseases shortly.
journal_name
Spectrochim Acta A Mol Biomol Spectroscauthors
Wang C,Shu W,Chen Q,Yang C,Su S,Gao M,Zhang R,Jing J,Zhang Xdoi
10.1016/j.saa.2021.119990keywords:
["Bioimaging","Fluorescent probe","Peroxynitrite","Viscosity"]subject
Has Abstractpub_date
2021-11-05 00:00:00pages
119990eissn
1386-1425issn
1873-3557pii
S1386-1425(21)00567-9journal_volume
260pub_type
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