Abstract:
:Background: Pulmonary arterial hypertension (PAH) is a severe and fatal clinical syndrome characterized by high blood pressure and vascular remodeling in the pulmonary arterioles, which is also a rapidly progressing disease of the lung vasculature with a poor prognosis. Although PAH medication made great advances in recent years, the efficacy and safety of the medication are unsatisfactory. Therefore, we aimed to update and expand previous studies to explore the efficacy and safety of PAH-targeted medications. Methods: Relevant articles were searched and selected from published or publicly available data in PubMed, Cochrane Library, CNKI, PsycInfo, and MEDLINE (from inception until October 1st, 2020). To assess the efficacy and safety of PAH therapies, five efficacy outcomes [6-minute walking distance (6MWD), mean pulmonary arterial pressure (mPAP), WHO functional class (WHO FC) improvement, clinical worsening, death] and two safety outcomes [adverse events (AEs), serious adverse events (SAEs)] were selected. And 6MWD was regarded as the primary efficacy outcome.Results: 50 trials included with 10 996participants were selected. In terms of efficacy, all targeted drugs were more effective than placebo. For 6MWD, Bosentan + Sildenafil, Sildenafil, Bosentan + Iloprost were better than others. Bosentan + Iloprost and Bosentan + Sildenafil were better for mPAP. Bosentan + Iloprost and Ambrisentan + Tadalafil were more effective in improving WHO FC. Bosentan + Tadalafil and Bosentan + Iloprost had the Ambrisentan probability to reduce the incidence of clinical worsening. It is demonstrated that Ambrisentan had clear benefits in reducing all-cause mortality. In terms of safety, no therapies had been shown to reduce the incidence of SAEs significantly, and Ambrisentan + Tadalafil significantly increased the incidence of AEs.Conclusions: Phosphodiesterase 5 inhibitor (PDE5i) + Endothelin Receptor Antagonists (ERA) seems to be better therapy for PAH. Prostacyclin analogs (ProsA) + ERA appear promising, though additional data is warranted.Registration PROSPERO CRD42020218818.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Fu W,He W,Li Y,Chen Y,Liang J,Lei H,Fu L,Chen Y,Ren N,Jiang Q,Shen Y,Ma R,Wang T,Wang X,Zhang N,Xiao D,Liu Cdoi
10.1080/10717544.2021.1927243keywords:
["Pulmonary arterial hypertension","network meta-analysis","targeted drug","treatment"]subject
Has Abstractpub_date
2021-12-01 00:00:00pages
1007-1019issue
1eissn
1071-7544issn
1521-0464journal_volume
28pub_type
杂志文章相关文献
DRUG DELIVERY文献大全abstract::Fine-multiple (water-in-oil-in-water) emulsions were prepared by two-step emulsification using sonication. They were coated with concanavalin-A (Con-A) by three methods. The one involving covalent coupling of Con-A to the multiple emulsion incorporated anchor was better compared with lipid derivatized Con-A anchoring ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/107175400266678
更新日期:2000-04-01 00:00:00
abstract::Gastric mucoadhesive drug delivery systems are very promising for eradication of Helicobacter pylori (H. pylori), a spiral bacterium that resides in the gastric mucus layer and at the mucus-epithelial cell interface. New positively charged biodegradable microspheres were prepared using aminated gelatin by surfactant-f...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/107175400455173
更新日期:2000-10-01 00:00:00
abstract::Unilamellar cationic liposomes have been prepared from an equimolar mixture of 3beta[N',N'-dimethylaminopropane)-carbomoyl] cholesterol (Chol-T), a higher homologue of 3beta[N',N'-dimethylaminoethane)-carbomoyl] cholesterol (DC-Chol), and dioleoylphosphatidyl-ethanolamine. The DNA binding capabilities of Chol-T and Ch...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/107175401300002739
更新日期:2001-01-01 00:00:00
abstract::The present study was aimed at kinetically characterizing the newly found carrier-mediated riboflavin transport system in the rat colon, comparing it with that in the small intestine, and also probing the potential roles of these transport systems in intestinal drug absorption. Riboflavin transport, evaluated by measu...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/107175401316906874
更新日期:2001-07-01 00:00:00
abstract::Prolonged circulation by liposomal incorporation has been shown to enhance the therapeutic efficacy of drugs in many cases. The purpose of this study was to investigate whether the prolonged circulation of methotrexate (MTX) can be achieved by modulating the liposomal compositions. Various compositions of liposomes we...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/107175401317245912
更新日期:2001-10-01 00:00:00
abstract::To develop a localized drug delivery system that offers prolonged administration of metronidazole into the periodontal pocket, muccoadhesive gel formulations containing 5% w/w metronidazole were prepared using the bioadhesive polymers: carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, polyvinylpirrolidon...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10426500290095601
更新日期:2002-04-01 00:00:00
abstract::The amphiphilic properties of poly(vinylalcohol) substituted with oleic acid was evaluated to assess the possibility to prepare polymeric micelles in an aqueous phase containing a hydrophobic core able to host lipophilic drugs such as retinyl palmitate and thereby enhance its transcutaneous absorption in the stratum c...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10426500290095647
更新日期:2002-07-01 00:00:00
abstract::The use of biomaterials as vehicles for pharmacological agents, hormones, and growth factors is at times the best treatment for controlled local administration. Our study was designed to evaluate the in vitro biocompatibility and potential clinical use of a new polymer, hydroxyethyl methacrylate-vinyl pirrolidone. Hum...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540260397846
更新日期:2002-10-01 00:00:00
abstract::A new cholesterol-carborane conjugate (BCH) has been synthesized as a potential targeting agent for boron neutron capture therapy (BNCT) of cancers. The compound is extremely water insoluble and was formulated in two liposomal formulations to determine if the compound could be adequately taken up by 9L rat glioma cell...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/713840324
更新日期:2003-01-01 00:00:00
abstract::The purpose of the present study was to determine whether intentional alteration of the secondary structure of a model polypeptide, conantokin-G, influenced the rate and extent of aqueous pore diffusion across a synthetic microporous membrane. Use of a microporous synthetic membrane allowed for analysis of polypeptide...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/713840357
更新日期:2003-04-01 00:00:00
abstract::Liposomal encapsulation of tuberculostatic drugs can potentially increase their therapeutic index. The incorporation of isoniazid, pyrazinamide, rifampicin, ethionamide, and streptomycin in extruded distearoylphosphatidylcholine/cholesterol liposomes designed for administration through inhalation was evaluated. Ethion...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/713840401
更新日期:2003-07-01 00:00:00
abstract::Niosomes of sorbitan monoesters (Span 20, 40, 60, and 80) were prepared using the film hydration method without sonication. Unlike the other surfactants, Span 80 did not form niosomes in the absence of a sufficient amount of cholesterol. The size of vesicles depended on the cholesterol molar ratio or charge incorporat...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/drd_10_4_251
更新日期:2003-10-01 00:00:00
abstract::The influence of ultrasound on percutaneous absorption of ketorolac tromethamine was studied in vitro across rat skin. Sonication was carried out with a continuous mode, at an intensity of 1-3 W/cm2 and a frequency of 1 MHz for 30 min. A significant increase in permeation of ketorolac through rat skin was observed wit...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490265261
更新日期:2004-01-01 00:00:00
abstract::The stability of liposomal formulations is a key issue in drug delivery. Liposomes made of egg phosphatidylcholine (EPC), cholesterol (Chol), sphingomyelin (SM), and gangliosides (GM1 and GM type III) were incubated in different media to determine their stability. Mixtures containing GM1 or GM type III were found to b...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490280769
更新日期:2004-03-01 00:00:00
abstract::Solid-lipid beads were prepared to retard the release rate of enrofloxacin and to mask its bitter taste using carrageenan or sodium alginate as a shell material and either cacao butter or Witepsol W-35 as a solid lipid core. Sodium alginate was a better shell material than carrageenan and the highest loading efficienc...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490265414
更新日期:2004-11-01 00:00:00
abstract::New vaccines based on subunits, synthetic peptides, or DNA need innovative adjuvants or antigen delivery systems: Spherulites are multilamellar vesicles made of incompatible lipid bilayers without any aqueous core. In this study, we evaluated their ability to induce immune responses against human serum albumin (HSA). ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490446026
更新日期:2005-03-01 00:00:00
abstract::This article reports on a comparative study on the ability of various polymers, containing hydrophilic and/or hydrophobic groups, to interact with a biomembrane model using the differential scanning calorimetry (DSC) technique. Multilamellar vesicles of mixed dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosph...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540590968404
更新日期:2005-11-01 00:00:00
abstract::Recently nasal delivery of insulin has gained considerable attention. Some limitations of this route include rapid mucociliary clearance of the drug from the site of deposition resulting in short time span available for absorption and low permeability of the nasal membrane for peptides. The objective of the present st...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500309040
更新日期:2006-01-01 00:00:00
abstract::A self-emulsifying system is a mixture of oil and surfactant that forms oil-in-water emulsion when exposed to aqueous fluid. It enhances the in vitro dissolution and improves the in vivo absorption of lipophilic drugs that have poor aqueous solubility. In this study, a poorly water soluble drug, piroxicam, was incorpo...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500313430
更新日期:2006-03-01 00:00:00
abstract::A new vegetable oil based oil-in-water microemulsion is developed and characterized as a prospective delivery system for in vivo application A particular weight percent composition 5/30/65 (clove oil/Tween-20/water) was selected (V1) from the clear oil-in-water zone of the pseudoternary phase diagram comprising clove ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500455983
更新日期:2006-05-01 00:00:00
abstract::In recent years, great attention has been paid to using solid dispersions to make sustained-release drugs. The objective of this study is to produce sustained-release systems of metoprolol tartrate using solid dispersion techniques and to evaluate their physicochemical characteristics. The solid dispersions were produ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500459308
更新日期:2006-07-01 00:00:00
abstract::Our aim was to improve the efficiency of nebulised budesonide using surface-active agents. Cationic, anionic, and nonionic detergents were added to commercial budesonide suspension, and the particle size distribution during nebulization was measured using both cascade impaction and laser diffraction. Our results showe...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500458862
更新日期:2006-09-01 00:00:00
abstract::In our pursuit to find potent anticancer drugs, we have covalently bonded free radical tempol to chlorambucil giving a chlorambucil-tempol (CT) adduct in which both of the anticancer active sites in tempol and chlorambucil were left intact. Analysis using NMR, Maldi-TOF, and EPR verified the designed chemical structur...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540600559452
更新日期:2006-11-01 00:00:00
abstract::This study involves development of amphiphilic gels consisting solely of nonionic surfactants bearing cyclosporine and characterized for microstructure, gelation temperature, and in vitro drug release into dermis. The formulation is nonirritant and suitable for topical application. Gels consisting of cyclosporine were...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540600642431
更新日期:2007-02-01 00:00:00
abstract::Two poly(DL-lactide-co-glycolide) microsphere formulations (A, 10% wt/wt, and B, 23% wt/wt, 1-10 microns) were evaluated for intracellular delivery of rifabutin using the J774 murine and Mono Mac 6 (MM6) human monocytic cell lines. Within 7 days, formulation A released 100% in both cell lines and B released 53 and 67%...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540600739815
更新日期:2007-03-01 00:00:00
abstract::Estradiol transdermal application still represents a relevant topic due to the recent controversies about hormone replacement therapy, its increasing potential in the treatment of skin aging and wound healing, and the new use of its derivatives in the transdermal contraceptive treatment. The aim of our work was to ver...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540601036849
更新日期:2007-04-01 00:00:00
abstract::Effect of lipid composition on encapsulation and stability of dexamethasone (DXM) incorporating multilamellar vesicles (MLV) is studied. MLVs composed of phosphatidylcholine (PC) or distearoyl-glycero-PC (DSPC), with or without cholesterol (Chol), are prepared and the release of DXM during vesicle incubation in buffer...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540701603530
更新日期:2007-10-01 00:00:00
abstract::Insulin stability during microencapsulation and subsequent release is essential for retaining its biological activity. The successful delivery of insulin relies on the proper selection of stabilizers in addition to other parameters. Attempts were made to address the problem with a few combination of stabilizers for ma...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540701606467
更新日期:2007-11-01 00:00:00
abstract::Cellulose xanthate-metal-tetracycline complexes (MCX-metal-Tc) were prepared and evaluated as a controlled release system for the antibiotics. Microcrystallized cellulose was chemically modified to cellulose xanthate (MCX). The amount of metal bound to MCX was 0.36 mmol Cu(II)/g MCX and 0.26 mmol Zn(II)/g MCX. Tetracy...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540701828723
更新日期:2008-01-01 00:00:00
abstract::This article describes buccal permeation of chlorpheniramine maleate (CPM) and its transbuccal delivery using mucoadhesive buccal patches. Permeation of CPM was calculated in vitro using porcine buccal membrane and in vivo in healthy humans. Buccal formulations were developed with hydroxyethylcellulose (HEC) and evalu...
journal_title:Drug delivery
pub_type: 临床试验,杂志文章
doi:10.1080/10717540801952639
更新日期:2008-03-01 00:00:00