Abstract:
:We have designed two mitochondria targetable probes P-Py and P-An by the π-conjugation of polyaromatic hydrocarbons (pyrene vs. anthracene) with 4-dimethylamino pyridinium. They present an amphiphilic property with excellent solubility in the common polar and non-polar solvents. Both of them demonstrated a significant fluorescence response to bisulfite in Tris-HCl buffer solutions (5 mM, pH = 7.4). By a combination of fluorescence, UV-vis, time-resolved emission, 1H NMR, and ESI-MS, their sensing mechanisms have been elaborated to be a Michael addition. Notably, P-Py also exhibits a sensitivity to the viscosity change with a Stokes shift of 140 nm, due to the restriction of C-C bond rotation. By taking advantages of its good water solubility, low toxicity, and high mitochondrial target, the dual responses of P-Py to exogenous SO2 derivatives and viscosity change in mitochondria were explored by confocal fluorescence microscopy.
journal_name
Spectrochim Acta A Mol Biomol Spectroscauthors
Wang X,Tang H,Huang Xdoi
10.1016/j.saa.2021.119902keywords:
["Bisulfite detection","Dual-detection","Fluorescent probe","Pyrene","Viscosity response"]subject
Has Abstractpub_date
2021-11-05 00:00:00pages
119902eissn
1386-1425issn
1873-3557pii
S1386-1425(21)00478-9journal_volume
260pub_type
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