Tissue factor potentiates adherence of breast cancer cells to human umbilical vein endothelial cells under static and flow conditions.

abstract：:Cutaneous malignant melanoma (CMM) begins in the epidermis as the clonal emergence of melanocytes having a deregulated mitotic cycle. In a manner not yet understood, some descendents of these cells loosen their adhesions in situ and migrate into the dermis, thus initiating the processes of invasion and metastasis. The...

journal_title：Cell adhesion & migration

authors： Pawelek JM

更新日期：2007-01-01 00:00:00

abstract：:Primordial Germ Cell (PGC) migration in zebrafish is guided by SDF-1a. Binding of this chemokine to its receptor CXCR4b activates downstream signalling cascades leading to cell polarization and directed migration towards the attractant source. Despite the detailed information available concerning the role of SDF-1 in ...

journal_title：Cell adhesion & migration

authors： Mahabaleshwar H,Boldajipour B,Raz E

更新日期：2008-04-01 00:00:00

abstract：:Many human gliomas carry markers characteristic of oligodendrocyte progenitor cells (such as Olig-2, PDGF alpha receptor and NG2 proteoglycan), suggesting these progenitors as the cells of origin for glioma initiation. This review considers the potential roles of the NG2 proteoglycan in glioma progression. NG2 is expr...

journal_title：Cell adhesion & migration

authors： Stallcup WB,Huang FJ

更新日期：2008-07-01 00:00:00

abstract：:The NFkappaB family of transcription factors, particularly the activated p50/p65 heterodimer, is expressed in vascular cells during intimal thickening formation when hemodynamic conditions are altered. Here, we report that p50, p65, IkappaBalpha and IKKalpha display different spatial and temporal patterns of expressio...

journal_title：Cell adhesion & migration

authors： Arciniegas E,Carrillo LM,De Sanctis JB,Candelle D

更新日期：2008-01-01 00:00:00

abstract：:Tubular sprouting in angiogenesis relies on division of labour between endothelial tip cells, leading and guiding the sprout, and their neighboring stalk cells, which divide and form the vascular lumen. We previously learned how the graded extracellular distribution of heparin-binding vascular endothelial growth facto...

journal_title：Cell adhesion & migration

authors： Hellström M,Phng LK,Gerhardt H

更新日期：2007-07-01 00:00:00

abstract：:OL-protocadherin is a member of the nonclustered-type protocadherin family. A recent study of ours showed that it is essential not only for growth of striatal axons but also for higher ordered neural circuit formation in the ventral telencephalon. The phenotype of OL-protocadherin-deficient mice is striking: several m...

journal_title：Cell adhesion & migration

authors： Hirano S

更新日期：2007-10-01 00:00:00

abstract：:Junctional Adhesion Molecule A (JAM-A) is a member of the Ig superfamily of membrane proteins expressed in platelets, leukocytes, endothelial cells and epithelial cells. We have previously shown that in endothelial cells, JAM-A regulates basic fibroblast growth factor, (FGF-2)-induced angiogenesis via augmenting endot...

journal_title：Cell adhesion & migration

authors： Naik UP,Naik MU

更新日期：2008-10-01 00:00:00

abstract：:Remodeling of joints is a key feature of inflammatory and degenerative joint disease. Bone erosion, cartilage degeneration and growth of bony spurs termed osteophytes are key features of structural joint pathology in the course of arthritis, which lead to impairment of joint function. Understanding their molecular mec...

journal_title：Cell adhesion & migration

authors： Schett G

更新日期：2007-04-01 00:00:00

abstract：:Cell motility, adhesion and actin cytoskeletal rearrangements occur upon integrin-engagement to the extracellular matrix and activation of the small family of Rho GTPases, RhoA, Rac1 and Cdc42. The activity of the GTPases is regulated through associations with guanine nucleotide exchange factors (GEFs), GTPase activat...

journal_title：Cell adhesion & migration

authors： Mohseni M,Chishti AH

更新日期：2009-04-01 00:00:00

abstract：:Postoperative peritoneal carcinomatosis is a significant clinical problem after "curative" resection of pancreatic carcinoma. Preoperative surgical trauma activates a cascade of peritoneal defense mechanisms responsible for postoperative intra-abdominal tumor recurrence. Reactive oxygen species (ROS) play a pivotal ro...

journal_title：Cell adhesion & migration

authors： ten Raa S,van Grevenstein HM,ten Kate M,Mangundap KM,Hofland LJ,Jeekel H,Sluiter W,van Eijck CH

更新日期：2007-04-01 00:00:00

abstract：:Stroke remains a major health problem worldwide, and is the leading cause of serious long-term disability. Recent findings now suggest that strategies to enhance angiogenesis after focal cerebral ischemia may provide unique opportunities to improve clinical outcomes during stroke recovery. In this mini-review, we surv...

journal_title：Cell adhesion & migration

authors： Navaratna D,Guo S,Arai K,Lo EH

更新日期：2009-04-01 00:00:00

abstract：:Fast growing malignant cancers represent a major therapeutic challenge. Basic cancer research has concentrated efforts to determine the mechanisms underlying cancer initiation and progression and reveal candidate targets for future therapeutic treatment of cancer patients. With known roles in fundamental processes req...

journal_title：Cell adhesion & migration

authors： Siesser PF,Maness PF

更新日期：2009-07-01 00:00:00

abstract：:To understand movement of amoeboid cells we have developed an information tool that automatically detects protrusions of moving cells. The algorithm uses digitized cell recordings at a speed of approximately 1 image per second that are analyzed in three steps. In the first part, the outline of a cell is defined as a p...

journal_title：Cell adhesion & migration

authors： Bosgraaf L,Van Haastert PJ

更新日期：2010-01-01 00:00:00

abstract：:During the last few years, several studies have pointed to a surprising link between environmental pollutants cellular signaling and important cell functions such as plasticity, adhesion and migration. This unexpected link could be related to endogenous functions of pollutants receptors that may be disrupted by enviro...

journal_title：Cell adhesion & migration

authors： Barouki R,Coumoul X

更新日期：2010-01-01 00:00:00

abstract：:Metastasis remains the leading cause of cancer morbidity and mortality. ErbB2, a metastasis-promoting oncoprotein, is overexpressed in 50-60% of noninvasive ductal carcinoma in situ (DCIS). However, only 25% of invasive breast cancer (IBC) overexpress ErbB2, indicating that ErbB2 alone is not sufficient to drive metas...

journal_title：Cell adhesion & migration

authors： Wang Y

更新日期：2010-01-01 00:00:00

abstract：:Neuropilins are highly conserved single pass transmembrane proteins specific to vertebrates. They were originally identified as adhesion molecules in the nervous system, but were subsequently rediscovered as the ligand binding subunit of the class 3 semaphorin receptor in neurons and then as blood vessel receptors for...

journal_title：Cell adhesion & migration

authors： Schwarz Q,Ruhrberg C

更新日期：2010-01-01 00:00:00

abstract：:Lung cancer is a complex spectrum of diseases characterized by extensive genomic instability, which can be detected among both histological subtypes and different foci within a tumor. Conventional and cutting edge investigative technologies have uncovered scores of genomic changes in individual specimens that have bee...

journal_title：Cell adhesion & migration

authors： Varella-Garcia M

更新日期：2010-01-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is a rare malignancy of the pleura with a very poor prognosis. Treatments evaluated for malignant mesothelioma, including chemotherapy, radiotherapy and surgery are of limited efficacy. However, the fact that the tumors of some patients with MPM regress spontaneously or respond to ...

journal_title：Cell adhesion & migration

authors： Grégoire M

更新日期：2010-01-01 00:00:00

abstract：:Multicellular organisms arise from the generation of different cell types and the organization of cells into tissues and organs. Cells of metazoa display two main phenotypes, the ancestral epithelial state and the recent mesenchymal derivative. Epithelial cells are usually stationary and reside in two-dimensional shee...

journal_title：Cell adhesion & migration

authors： Ferrer-Vaquer A,Viotti M,Hadjantonakis AK

更新日期：2010-07-01 00:00:00

abstract：:The interaction between transmembrane helices is of great interest because it directly determines biological activity of a membrane protein. Either destroying or enhancing such interactions can result in many diseases related to dysfunction of different tissues in human body. One much studied form of membrane proteins...

journal_title：Cell adhesion & migration

authors： Bocharov EV,Volynsky PE,Pavlov KV,Efremov RG,Arseniev AS

更新日期：2010-04-01 00:00:00

abstract：:Integrin receptors cluster on the cell surface and bind to extra cellular matrix (ECM) proteins triggering the formation of focal contacts and the activation of various signal transduction pathways that affect the morphology, motility, gene expression and survival of adherent cells. Polyamine depletion prevents the in...

journal_title：Cell adhesion & migration

authors： Elias BC,Bhattacharya S,Ray RM,Johnson LR

更新日期：2010-07-01 00:00:00

abstract：:In neural crest cell development, the expression of the cell adhesion proteins cadherin-7 and cadherin-11 commences after delamination of the neural crest cells from the neuroepithelium. The canonical Wnt signaling pathway is known to drive this delamination step and is a candidate for inducing expression of these cad...

journal_title：Cell adhesion & migration

authors： Chalpe AJ,Prasad M,Henke AJ,Paulson AF

更新日期：2010-07-01 00:00:00

abstract：:Neural crest cells (NCCs) are a remarkable, dynamic group of cells that travel long distances in the embryo to reach their target sites. They are responsible for the formation of craniofacial bones and cartilage, neurons and glia in the peripheral nervous system, and pigment cells. Live imaging of NCCs as they travers...

journal_title：Cell adhesion & migration

authors： Clay MR,Halloran MC

更新日期：2010-10-01 00:00:00

abstract：:Neural crest cells (NCCs) are migratory cells that delaminate from the neural tube early in development and then disseminate throughout the embryo to give rise to a wide variety of cell types that are key to the vertebrate body plan. During their journey from the neural tube to their peripheral targets, NCCs progressi...

journal_title：Cell adhesion & migration

authors： Ruhrberg C,Schwarz Q

更新日期：2010-10-01 00:00:00

abstract：:The process of epithelial lumenogenesis requires coordination of a network of signaling machinery communicated to each cell through subsequent cell divisions. Formation of a single hollow lumen has previously been shown to require Tuba, a Cdc42 GEF, for Cdc42 activation and correct spindle orientation. Using a Caco-2 ...

journal_title：Cell adhesion & migration

authors： Kovacs EM,Verma S,Thomas SG,Yap AS

更新日期：2011-07-01 00:00:00

abstract：:Recent advances in confocal and multi-photon microscopy, together with fluorescent probe development, have enabled cancer biology studies to go beyond the culture dish and interrogate cancer-associated processes in the complex in vivo environment. Regulation of the tumor suppressor protein E-cadherin plays an importan...

journal_title：Cell adhesion & migration

authors： Serrels A,Canel M,Brunton VG,Frame MC

更新日期：2011-07-01 00:00:00

abstract：:Slender bundled actin containing plasma membrane protrusions, called filopodia, are important for many essential cellular processes like cell adhesion, migration, angiogenesis and the formation of cell-cell contacts. In migrating cells, filopodia are the pioneers at the leading edge which probe the environment for cue...

journal_title：Cell adhesion & migration

authors： Arjonen A,Kaukonen R,Ivaska J

更新日期：2011-09-01 00:00:00

abstract：:Recent findings suggest that Ring finger protein 146 (RNF146), also called iduna, have neuroprotective property due to its inhibition of Parthanatos via binding with Poly(ADP-ribose) (PAR). The Parthanatos is a PAR dependent cell death that has been implicated in many human diseases. RNF146/Iduna acts as a PARsylation...

journal_title：Cell adhesion & migration

authors： Zhou ZD,Chan CH,Xiao ZC,Tan EK

更新日期：2011-11-01 00:00:00

abstract：:Cellular locomotion and adhesion critically depend on regulated turnover of filamentous actin. Biochemical data from diverse model systems support a role for the family of small heat shock proteins (HSPBs) in microfilament regulation. The small chaperones could either act directly, through competition with the motor m...

journal_title：Cell adhesion & migration

authors： Montagna GN,Matuschewski K,Buscaglia CA

更新日期：2012-03-01 00:00:00

abstract：:The adherens junction (AJ) comprises multi-protein complexes required for cell-cell adhesion in embryonic development and adult tissue homeostasis. Mutations in key proteins and mis-regulation of AJ adhesive properties can lead to pathologies such as cancer. In recent years, the zebrafish has become an excellent model...

journal_title：Cell adhesion & migration

authors： Schepis A,Nelson WJ

更新日期：2012-05-01 00:00:00