Injectable oxygenation therapeutics: evaluating the oxygen delivery efficacy of artificial oxygen carriers and kosmotropes in vitro.

abstract：:A series of gelatin hydrogels were prepared by crosslinking method using glutaraldehyde (GA). The hydrogels were characterized by gel formation, swelling/degradation tests, and FTIR analysis. The variations of swelling percentages (S%) with time, temperature, and pH were determined. It is found that the increasing amo...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Pulat M,Akalin GO

更新日期：2013-06-01 00:00:00

abstract：:Tuberculosis (TB) remains one of the oldest and deadliest diseases in the current scenario. The intracellular organism Mycobacterium tuberculosis, which mainly resides in mononuclear phagocytes, is responsible for tuberculosis in humans. A few therapies are available for the treatment of tuberculosis but they have man...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Bhardwaj A,Kumar L,Narang RK,Murthy RS

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Enzymatical conversion of A or B RBCs into group O RBCs (ECORBCs) was achieved by using α-N-acetylgalactosaminidase and α-galactosidase, respectively. Now, we initiated AB to O-RBC conversion by using these two enzymes together. But α-N-acetylgalactosaminidase and α-galactosidase's preserving and their react...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Gao H,Li S,Tan Y,Ji S,Wang Y,Bao G,Xu L,Gong F

更新日期：2013-02-01 00:00:00

abstract：:Multiple therapeutic activities attributed to curcumin deliver a challenge to explore its hidden qualities. Structural features set an opportunity to chelate metal ions and enhance the therapeutics in a specified direction. A metallo-herbal complex (MHco) of curcumin with copper (Cu(2+)) ions was synthesized and chara...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Chauhan G,Rath G,Goyal AK

更新日期：2013-08-01 00:00:00

abstract：:Hemoglobin (Hb) derivatization for blood substitute purposes often involves multi-step processes including redox reagents such as borohydride and periodate, with possible subsequent side effects. Disuccinimidyl suberate (DSS) allows protein cross-linking without toxic side-products, forming one-step peptide bonds with...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Scurtu F,Zolog O,Iacob B,Silaghi-Dumitrescu R

更新日期：2014-02-01 00:00:00

abstract：:In this work, doxorubicin (DOX)-loaded magnetic albumin nanospheres were prepared using desolvation method in order to develop magnetically responsive nanocarrier system. Nanoparticles were characterized with zetasizer, SEM, AFM, XRD and magnetometer. In vitro DOX release was also investigated. It was found that nanop...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Ak G,Yɪlmaz H,Sanlɪer SH

更新日期：2014-02-01 00:00:00

abstract：:In this study, a novel carbon paste electrode (CPE) was prepared using the salt form of polyaniline (pani)-silicon dioxide composite that is sensitive to choline. Choline oxidase (ChO) enzyme was immobilized to modified carbon paste electrode (MCPE) by cross-linking with glutaraldehyde. Determination of choline was ca...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Özdemir M,Arslan H

更新日期：2014-02-01 00:00:00

abstract：:In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Karataş MO,Alici B,Cakir U,Cetinkaya E,Demir D,Ergün A,Gençer N,Arslan O

更新日期：2014-06-01 00:00:00

abstract：:This study was conducted to evaluate the antimutagenic and antimicrobial activities of Schiff bases attached L-glutamine and L-asparagine. Antibacterial activities of the compounds against S. aureus, Sh. dys. typ 7, L. monocytogenes 4b, E. coli, S. typhi H, S. epidermis, Br. abortus, M. luteus, B. cereus, P. putida, a...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Sakiyan I,Anar M,Oğütcü H,Agar G,Sarı N

更新日期：2014-06-01 00:00:00

abstract：:A series of 3D implants and filling materials prepared from powdered biodegradable polymers, polyhydroxyalkanoates (PHAs), have been designed for the purposes of reparative osteogenesis. The 3D implants are made of resorbable polymer of hydroxybutyric acid (poly-3-hydroxybutyrate, P3HB) and a composite of this polymer...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Shishatskaya EI,Kamendov IV,Starosvetsky SI,Vinnik YS,Markelova NN,Shageev AA,Khorzhevsky VA,Peryanova OV,Shumilova AA

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:This study evaluated the potential for prepared chitosan-plasmid DNA (pDNA) nanoparticles to transfer an exogenous gene into human bone marrow-derived mesenchymal stem cells (MSCs). METHODS:Chitosan-pDNA nanoparticles were synthesized by the complex coacervation method. We used 18, 50 and 136 KD chitosan at co...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Malakooty Poor E,Baghaban Eslaminejad M,Gheibi N,Bagheri F,Atyabi F

更新日期：2014-12-01 00:00:00

abstract：:Abstract NIPA and HEMA-lactate-Dextran-based biodegradable and thermoresponsive cryogels were synthesized at different compositions by cryogelation. Chemical and morphological properties of the HEMA-lactate-Dextran-co-NIPA cryogel matrices were demonstrated by FTIR, SEM, and ESEM. Thermoresponsivity of the prepared cr...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Bölgen N,Aguilar MR,Fernández Mdel M,Gonzalo-Flores S,Villar-Rodil S,San Román J,Pişkin E

更新日期：2015-02-01 00:00:00

abstract：:Psoriasis is an autoimmune, chronic, inflammatory skin disease characterized by epidermal hyperplasia, proliferation of blood vessels, and infiltration of leukocytes in dermis and epidermis. Several immunosuppressants such as methotrexate (MXT) and cyclosporine are used but they are associated with adverse effects due...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Parnami N,Garg T,Rath G,Goyal AK

更新日期：2014-12-01 00:00:00

abstract：:Pancreatic trypsin was immobilized by cross-linked enzyme aggregates (CLEA) which is a carrier free immobilization method. Ammonium sulfate was chosen for enzyme precipitation which was followed by cross linking of formed aggregates via glutaraldehyde. Concentrations of precipitant and cross linker were respectively o...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Menfaatli E,Zihnioglu F

更新日期：2015-04-01 00:00:00

abstract：:To testify the targeting effect of PEGylated Oxaliplatin polylactic acid (OP-PEG-PLA) nanoparticles (NPs), we studied drug concentration in rabbit plasma and tissue distribution in tumor-bearing mice. Concentration of nanoparticle colloidal solution was performed with dialysis. Qualities of enriched NPs were character...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Wei H,Xu L,Sun Y,Li G,Cui Z,Yan G,Chen Q,Yin H,Ma C

更新日期：2015-01-01 00:00:00

abstract：:Gold nanoparticles have tremendous application in the area of nanotechnology that raises new possibility in the treatment of brain tumor. These nanoparticles can be used for selectively gaining access to tumor due to their small size and modifiability. Gold nanoparticles are functionalized with various molecules such ...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Tripathi RM,Shrivastav A,Shrivastav BR

更新日期：2015-01-01 00:00:00

abstract：:The aim of the present study is to design a mucoadhesive nano-carrier system which retains at the site of application and maximizes the therapeutic potential of anticancer drug as well as reduces their systemic side effects. In the present study PVA nanofibers of Docetaxel were prepared using electrospinning machine. ...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Singh H,Sharma R,Joshi M,Garg T,Goyal AK,Rath G

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:PEGylated hemoglobin (Hb) is a promising oxygen therapeutic agent for clinical application. However, it suffered from structural perturbation, functional instability and methemoglobin (metHb) formation. OBJECTIVE:To improve the structural, functional, physical and anti-oxidation properties of the PEGylated Hb....

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Wang Q,Hu T,Sun L,Ji S,Zhao D,Liu J,Ma G,Su Z

更新日期：2015-02-01 00:00:00

abstract：:Acne is a chronic inflammatory human skin disease, characterized by areas of skin with seborrhoea, comedones, papules, nodules, pimples, and possibly scarring with lesions occurring on face, neck, and back. Nanotechnological approaches such as particulate (solid lipid nanoparticles and microspheres), vesicular (liposo...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Garg T

更新日期：2016-01-01 00:00:00

abstract：:Quercetin (3,5,7,3',4'-pentahydroxyflavone) is a natural bio-flavonoid originating from fruits, vegetables, seeds, berries, and tea. The antioxidant activity of quercetin and its protective effects against cardiovascular disorders, anti-cancer, anti-inflammatory, and anti-viral activities have been extensively documen...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Rezaei-Sadabady R,Eidi A,Zarghami N,Barzegar A

更新日期：2016-01-01 00:00:00

abstract：:The objectives were to study the potential of Althaea officinalis radix in production of silver NPs, and the effect of the extract ethanol concentration on the produced NPs. Seventy and ninety-six percent hydroalcoholic extracts were prepared by percolation of the plant powder. The extract was concentrated by rotary e...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Korbekandi H,Asghari G,Chitsazi MR,Bahri Najafi R,Badii A,Iravani S

更新日期：2016-01-01 00:00:00

abstract：:Malemide polyethylene glycol-conjugated Hb (MP4OX, Sangart Inc.), a high-affinity low-concentration acellular hemoglobin (P50 = 5 mmHg, 4.3 g/dl) solution, has been shown to optimize microvascular perfusion and target oxygen delivery to anoxic tissue. Microvascular perfusion during an acute hypoxic challenge in a tran...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Tsai AG,Cabrales P,Young MA,Winslow RM,Intaglietta M

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVES:The repairing of large segmental bone defects is difficult for clinical orthopedists at present. Gene therapy is regarded as a promising method for bone defects repair. The present study aimed to construct an effective and controllable Tet-On expression system for transferring hBMP-2 gene into bone marrow me...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Qian D,Bai B,Yan G,Zhang S,Liu Q,Chen Y,Tan X,Zeng Y

更新日期：2016-01-01 00:00:00

abstract：:Hydroxyapatite (HA), the main mineral component of bones and teeth, was synthesized by using the reaction between calcium nitrate tetrahydrate Ca(NO3)2∙4H2O and diammonium hydrogen phosphate (NH4)2HPO4 (DAHP) with a chemical precipitation method. The objective of this study is to utilize novel inorganic-organic nanoco...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Chung JH,Kim YK,Kim KH,Kwon TY,Vaezmomeni SZ,Samiei M,Aghazadeh M,Davaran S,Mahkam M,Asadi G,Akbarzadeh A

更新日期：2016-01-01 00:00:00

abstract：AIM:In the present paper, paclitaxel (PTX)-loaded stealth liposomes were prepared with thin film hydration technique in order to prolong the time of circulation. METHOD:The liposomes' characterization, in vitro release, pharmacokinetics, and biodistribution profile of the drug were investigated. RESULTS:Microscope sh...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Xu Y,Meng H

更新日期：2016-01-01 00:00:00

abstract：:Aim of the study was to develop solid lipid nanoparticles (SLN) of triamcinolone acetonide (TA) and to study the effect of various process variables in order to optimize the formulation for effective delivery. Drug loaded SLNs were successfully prepared and characterized by TEM, XRD and DSC study. Process variables li...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Pradhan M,Singh D,Singh MR

更新日期：2016-01-01 00:00:00

abstract：:The purpose of the present work is to improve the antimalarial activity of the drug arteether (AE) by enhancing its solubility, by loading it into a nanostructured lipid carrier (NLC). The in vitro drug release profile of the NLC showed 93% drug release in 32 h. Complete eradication of the parasite from the blood and ...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Ali Z,Mishra N,Baldi A

更新日期：2016-01-01 00:00:00

abstract：:This study utilized the Seahorse Analyzer to examine the effect of the bile acid ursodeoxycholic acid (UDCA), on the morphology, swelling, stability, and size of novel microencapsulated β-cells, in real-time. UDCA was conjugated with fluorescent compounds, and its partitioning within the microcapsules was examined usi...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Mooranian A,Negrulj R,Chen-Tan N,Fakhoury M,Arfuso F,Jones F,Al-Salami H

更新日期：2016-01-01 00:00:00

abstract：:Cell transplantation is a promising regenerative therapy for cartilage degeneration. However, obtaining sufficient numbers of cells for this purpose is a challenge, due a lack of autologous donor tissue and the difficulty of culturing chondrocytes in vitro. Tissue engineering strategies that induce or maintain chondro...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Youngstrom DW,Cakstina I,Jakobsons E

更新日期：2016-05-01 00:00:00

abstract：:Iron chelation therapy can be used for the selective removal of Fe(3+) ions from spiked human plasma by ion imprinting. N-Methacryloyl-(L)-glutamic acid (MAGA) was chosen as the chelating monomer. In the first step, MAGA was complexed with the Fe(3+) ions to prepare the precomplex, and then the ion-imprinted poly(hydr...

journal_title：Artificial cells, nanomedicine, and biotechnology

authors： Çimen D,Göktürk I,Yılmaz F

更新日期：2016-06-01 00:00:00