Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain.

abstract：BACKGROUND:Acute and chronic pain in axial structures, like the back and neck, are difficult to treat, and have incidence as high as 15%. Surprisingly, most preclinical work on pain mechanisms focuses on cutaneous structures in the limbs and animal models of axial pain are not widely available. Accordingly, we develope...

journal_title：Molecular pain

authors： Harris BM,Hughes DI,Bolton PS,Tadros MA,Callister RJ,Graham BA

更新日期：2014-04-12 00:00:00

abstract：BACKGROUND:A chronic compressed dorsal root ganglion (CCD) in rat produces pain behavior and an enhanced excitability of neurons within the compressed ganglion. Kir2.1 is an inwardly rectifying potassium channel that acts to stabilize the resting potential of certain cell types. We hypothesized that an inducible expres...

journal_title：Molecular pain

authors： Ma C,Rosenzweig J,Zhang P,Johns DC,LaMotte RH

更新日期：2010-10-06 00:00:00

abstract：INTRODUCTION:Neuropathic pain is believed to be influenced in part by inflammatory processes. In this study we examined the effect of variability in the C-type lectin gene cluster (Aplec) on the development of neuropathic pain-like behavior after ligation of the L5 spinal nerve in the inbred DA and the congenic Aplec s...

journal_title：Molecular pain

authors： Dominguez CA,Carlström KE,Zhang XM,Al Nimer F,Lindblom RP,Ortlieb Guerreiro-Cacais A,Piehl F

更新日期：2014-12-10 00:00:00

abstract：BACKGROUND:Prostatic acid phosphatase (PAP) and ecto-5'-nucleotidase (NT5E, CD73) produce extracellular adenosine from the nucleotide AMP in spinal nociceptive (pain-sensing) circuits; however, it is currently unknown if these are the main ectonucleotidases that generate adenosine or how rapidly they generate adenosine...

journal_title：Molecular pain

authors： Street SE,Walsh PL,Sowa NA,Taylor-Blake B,Guillot TS,Vihko P,Wightman RM,Zylka MJ

更新日期：2011-10-19 00:00:00

abstract：Abstract:Neuropathic pain induced by chemotherapy drugs such as oxaliplatin is a dose-limiting side effect in cancer treatment. The mechanisms underlying chemotherapy-induced neuropathic pain are not fully understood. KCNQ2 channels are low-threshold voltage-gated K+ channels that play a role in controlling neuronal ex...

journal_title：Molecular pain

authors： Ling J,Erol F,Viatchenko-Karpinski V,Kanda H,Gu JG

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The peptide neurotransmitter N-Acetylaspartylglutamate (NAAG) is the third most prevalent transmitter in the mammalian central nervous system. Local, intrathecal and systemic administration of inhibitors of enzymes that inactivate NAAG decrease responses to inflammatory pain in rat models. Consistent with NA...

journal_title：Molecular pain

authors： Yamamoto T,Kozikowski A,Zhou J,Neale JH

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Genome-wide association studies have identified TRPM8 (transient receptor potential melastatin 8) as one of the susceptibility genes for common migraine. Here, we investigated the postnatal changes of TRPM8-expressing dural afferent fibers as well as the function of dural TRPM8 channels in mice. RESULTS:Fir...

journal_title：Molecular pain

authors： Ren L,Dhaka A,Cao YQ

更新日期：2015-06-26 00:00:00

abstract：BACKGROUND:It has been reported that the P2Y12 receptor (P2Y12R) is involved in satellite glial cells (SGCs) activation, indicating that P2Y12R expressed in SGCs may play functional roles in orofacial neuropathic pain mechanisms. However, the involvement of P2Y12R in orofacial neuropathic pain mechanisms is still unkno...

journal_title：Molecular pain

authors： Katagiri A,Shinoda M,Honda K,Toyofuku A,Sessle BJ,Iwata K

更新日期：2012-03-30 00:00:00

abstract：BACKGROUND:Clearance of synaptically released glutamate, and hence termination of glutamatergic neurotransmission, is carried out by glutamate transporters, most especially glutamate transporter-1 (GLT-1) and the glutamate-aspartate transporter (GLAST) that are located in astrocytes. It is becoming increasingly well ap...

journal_title：Molecular pain

authors： Xin WJ,Weng HR,Dougherty PM

更新日期：2009-03-26 00:00:00

abstract：BACKGROUND:The development of pain after peripheral nerve and tissue injury involves not only neuronal pathways but also immune cells and glia. Central sensitization is thought to be a mechanism for such persistent pain, and ATP involves in the process. We examined the contribution of glia to neuronal excitation in the...

journal_title：Molecular pain

authors： Ikeda H,Kiritoshi T,Murase K

更新日期：2012-06-15 00:00:00

abstract：:Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse side effect of many anti-cancer chemotherapeutic treatments. CIPN often causes neuropathic pain in extremities, and oxidative stress has been shown to be a major contributing factor to this pain. In this study, we determined the site of oxidative stress a...

journal_title：Molecular pain

authors： Shim HS,Bae C,Wang J,Lee KH,Hankerd KM,Kim HK,Chung JM,La JH

更新日期：2019-01-01 00:00:00

abstract：:The Eighth Scientific Meeting of The TMJ Association, Ltd. was held in Bethesda, Maryland, September 11-13, 2016. As in the past, the meeting was cosponsored by components of the National Institutes of Health with speakers invited to review the state of temporomandibular disorder science and propose recommendations to...

journal_title：Molecular pain

authors： Wilentz JB,Cowley AW Jr

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Cadmium (Cd) is an environmental pollutant and acute exposure to it causes symptoms related to pain and inflammation in the airway and gastrointestinal tract, but the underlying mechanisms are still unclear. TRPA1 is a nonselective cation channel expressed in sensory neurons and acts as a nociceptive recepto...

journal_title：Molecular pain

authors： Miura S,Takahashi K,Imagawa T,Uchida K,Saito S,Tominaga M,Ohta T

更新日期：2013-02-28 00:00:00

abstract：BACKGROUND:Because excessive reduction in activities after back injury may impair recovery, it is important to understand and address the factors contributing to the variability in motor responses to pain. The current dominant theory is the "fear-avoidance model", in which the some patients' heightened fears of further...

journal_title：Molecular pain

authors： Mishra BK,Wu T,Belfer I,Hodgkinson CA,Cohen LG,Kiselycznyk C,Kingman A,Keller RB,Yuan Q,Goldman D,Atlas SJ,Max MB

更新日期：2007-07-26 00:00:00

abstract：:Synaptogenesis is a highly controlled process, involving a vast array of players which include cell adhesion molecules, scaffolding and signaling proteins, neurotransmitter receptors and proteins associated with the synaptic vesicle machinery. These molecules cooperate in an intricate manner on both the pre- and posts...

journal_title：Molecular pain

authors： Levinson JN,El-Husseini A

更新日期：2005-03-23 00:00:00

abstract：:Surgical incision-induced nociception contributes to the occurrence of postoperative cognitive dysfunction. However, the exact mechanisms involved remain unclear. Brain-derived neurotrophic factor (BDNF) has been demonstrated to improve fear learning ability. In addition, BDNF expression is influenced by the periphera...

journal_title：Molecular pain

authors： Liu Z,Liu F,Liu X,Ma C,Zhao J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Pain is the most prominent non-motor symptom observed in patients with Parkinson's disease (PD). However, the mechanisms underlying the generation of pain in PD have not been well studied. We used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD to analyze the relationship betw...

journal_title：Molecular pain

authors： Park J,Lim CS,Seo H,Park CA,Zhuo M,Kaang BK,Lee K

更新日期：2015-05-17 00:00:00

abstract：BACKGROUND:Since bone marrow receives innervation from A-delta and C-fibers and since an increase in intramedullary pressure in bone marrow may induce acute pain in orthopedic patients during surgery and chronic pain in patients with bone marrow edema, skeletal pain may partly originate from bone marrow. Intraosseous l...

journal_title：Molecular pain

authors： Ishida T,Tanaka S,Sekiguchi T,Sugiyama D,Kawamata M

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The vanilloid receptor 1 (TRPV1) is critical in the development of inflammatory hyperalgesia. Several receptors including G-protein coupled prostaglandin receptors have been reported to functionally interact with the TRPV1 through a cAMP-dependent protein kinase A (PKA) pathway to potentiate TRPV1-mediated c...

journal_title：Molecular pain

authors： Vetter I,Wyse BD,Monteith GR,Roberts-Thomson SJ,Cabot PJ

更新日期：2006-07-16 00:00:00

abstract：:Group I mGluRs (mGluR1 and 5) pre- and/or postsynaptically regulate synaptic transmission at glutamatergic synapses. By recording spontaneous EPSCs (sEPSCs) in the spinal trigeminal subnucleus oralis (Vo), we here investigated the regulation of glutamatergic transmission through the activation of group I mGluRs. Bath-...

journal_title：Molecular pain

authors： Song JH,Park ES,Han SM,Han SR,Ahn DK,Youn DH

更新日期：2009-09-02 00:00:00

abstract：:Although a variety of industrial chemicals, as well as several chemotherapeutic agents used to treat cancer or HIV, preferentially induce a peripheral sensory neuropathy what remains unclear is why these agents induce a sensory vs. a motor or mixed neuropathy. Previous studies have shown that the endothelial cells tha...

journal_title：Molecular pain

authors： Jimenez-Andrade JM,Herrera MB,Ghilardi JR,Vardanyan M,Melemedjian OK,Mantyh PW

更新日期：2008-03-19 00:00:00

abstract：:Objective Previous studies of neuropathic pain have suggested that the P2X4 purinoceptor (P2X4R) in spinal microglia is essential for maintaining allodynia following nerve injury. However, little is known about its role in inflammatory soup-induced trigeminal allodynia, which closely mimics chronic migraine status. He...

journal_title：Molecular pain

authors： Liu C,Zhang Y,Liu Q,Jiang L,Li M,Wang S,Long T,He W,Kong X,Qin G,Chen L,Zhang Y,Zhou J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Oxaliplatin, the third-generation platinum compound, has evolved as one of the most important therapeutic agents in colorectal cancer chemotherapy. The main limiting factor in oxaliplatin treatment is painful neuropathy that is difficult to treat. This side effect has been studied for several years, but its ...

journal_title：Molecular pain

authors： Azevedo MI,Pereira AF,Nogueira RB,Rolim FE,Brito GA,Wong DV,Lima-Júnior RC,de Albuquerque Ribeiro R,Vale ML

更新日期：2013-10-23 00:00:00

abstract：BACKGROUND:Bone metastases occur frequently in advanced breast, lung, and prostate cancer, with approximately 70% of patients affected. Pain is a major symptom of bone metastases, and current treatments may be inadequate or have unacceptable side effects. The mechanisms that drive cancer-induced bone pain are not fully...

journal_title：Molecular pain

authors： De Felice M,Lambert D,Holen I,Escott KJ,Andrew D

更新日期：2016-04-18 00:00:00

abstract：BACKGROUND:Our previous studies have shown that complete Freund's adjuvant (CFA)-induced masseter inflammation and microinjection of the pro-inflammatory cytokine interleukin-1β (IL-1β) into the subnucleus interpolaris/subnucleus caudalis transition zone of the spinal trigeminal nucleus (Vi/Vc) can induce contralateral...

journal_title：Molecular pain

authors： Chai B,Guo W,Wei F,Dubner R,Ren K

更新日期：2012-10-23 00:00:00

abstract：:Congenital insensitivity to pain (OMIM 243000) is an extremely rare disorder caused by loss-of-function mutations in SCN9A encoding Nav1.7. Although the SCN9A mutations and phenotypes of painlessness and anosmia/hyposmia in patients are previously well documented, the complex relationship between genotype and phenotyp...

journal_title：Molecular pain

authors： Sun J,Li L,Yang L,Duan G,Ma T,Li N,Liu Y,Yao J,Liu JY,Zhang X

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:To evaluate whether P2X receptors are involved in responses to noxious pulp stimulation, the P2X3 and P2X2/3 receptor agonist α,β-methyleneATP (α,β-meATP) was applied to the molar tooth pulp and nocifensive behavior and extracellular-signal regulated kinase (ERK) phosphorylation in trigeminal spinal subnucle...

journal_title：Molecular pain

authors： Adachi K,Shimizu K,Hu JW,Suzuki I,Sakagami H,Koshikawa N,Sessle BJ,Shinoda M,Miyamoto M,Honda K,Iwata K

更新日期：2010-09-22 00:00:00

abstract：OBJECTIVE:To investigate the impacts of anti-nerve growth factor antibody on pain-related behaviors and expressions of μ-opioid receptor in spinal dorsal horn and dorsal root ganglia of rats with cancer-induced bone pain. METHODS:The rats were randomly grouped and then injected with 10 μl of phosphate buffer saline or...

journal_title：Molecular pain

authors： Yao P,Ding Y,Wang Z,Ma J,Hong T,Zhu Y,Li H,Pan S

更新日期：2016-04-26 00:00:00

abstract：BACKGROUND:Minocycline prevents the development of neuropathic and inflammatory pain by inhibiting microglial activation and postsynaptic currents. But, how minocycline obviates acute visceral pain is unclear. The present study investigated whether minocycline had an any antinociceptive effect on acetic acid-induced ac...

journal_title：Molecular pain

authors： Cho IH,Lee MJ,Jang M,Gwak NG,Lee KY,Jung HS

更新日期：2012-02-24 00:00:00

abstract：:Long-term potentiation (LTP) at synapses of nociceptive nerve fibres is a proposed cellular mechanism underlying some forms of hyperalgesia. In this review fundamental properties of LTP in nociceptive pathways are described. The following topics are specifically addressed: A concise definition of LTP is given and a di...

journal_title：Molecular pain

authors： Sandkühler J

更新日期：2007-04-03 00:00:00