Abstract：
BACKGROUND:Increased serum levels of homocysteine and uric acid have each been associated with cardiovascular risk. We analyzed whether homocysteine and uric acid were associated with glomerular filtration rate (GFR) and albuminuria independently of each other. We also investigated the association of MTHFR polymorphisms related to homocysteine with albuminuria to get further insight into causality. METHODS:This was a cross-sectional population-based study in Caucasians (n = 5913). Hyperhomocysteinemia was defined as total serum homocysteine ≥ 15 μmol/L. Albuminuria was defined as urinary albumin-to-creatinine ratio > 30 mg/g. RESULTS:Uric acid was associated positively with homocysteine (r = 0.246 in men and r = 0.287 in women, P < 0.001). The prevalence of albuminuria increased across increasing homocysteine categories (from 6.4% to 17.3% in subjects with normal GFR and from 3.5% to 14.5% in those with reduced GFR, P for trend < 0.005). Hyperhomocysteinemia (OR = 2.22, 95% confidence interval: 1.60-3.08, P < 0.001) and elevated serum uric acid (OR = 1.27, 1.08-1.50, per 100 μmol/L, P = 0.004) were significantly associated with albuminuria, independently of hypertension and type 2 diabetes. The 2-fold higher risk of albuminuria associated with hyperhomocysteinemia was similar to the risk associated with hypertension or diabetes. MTHFR alleles related to higher homocysteine were associated with increased risk of albuminuria. CONCLUSIONS:In the general adult population, elevated serum homocysteine and uric acid were associated with albuminuria independently of each other and of renal function.
journal_name
BMC Public Healthjournal_title
BMC public healthauthors
Marti F,Vollenweider P,Marques-Vidal PM,Mooser V,Waeber G,Paccaud F,Bochud Mdoi
10.1186/1471-2458-11-733subject
Has Abstractpub_date
2011-09-26 00:00:00pages
733issn
1471-2458pii
1471-2458-11-733journal_volume
11pub_type
杂志文章abstract：BACKGROUND:In response to increases in methamphatemine-associated sexually transmitted diseases, the San Francisco Department of Public Health implemented a contingency management (CM) field program called the Positive Reinforcement Opportunity Project (PROP). METHODS:Methamphetamine-using men who have sex with men (M...
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