Comprehensive analysis of differentially expressed genes reveals the promotive effects of UBE2T on colorectal cancer cell proliferation.

abstract：:Angiotensin II AT(2) receptor interacting protein 1 (ATIP1) has been recently identified as a tumor suppressor. In the present study, a 2.2 kb fragment of the 5' flanking region of the human ATIP1 gene was cloned, and its promoter activity was confirmed. Two putative p53 binding sites were identified in the minimal pr...

journal_title：Oncology letters

authors： Chen Z,Liu X,Wang C,Jin Y,Wang Y,Wang A,Zhou X

更新日期：2011-09-01 00:00:00

abstract：:Proteolipid protein 2 (PLP2) promotes the metastasis of B16F10 cells in an experimental metastasis model. However, the effect of PLP2 on spontaneous metastasis has yet to be demonstrated, and whether PLP2 may become a new therapeutic target for malignant tumors is as yet unknown. In this study, PLP2 or focal adhesion ...

journal_title：Oncology letters

authors： Ozawa H,Sonoda Y,Suzuki T,Yoshida-Hoshina N,Funakoshi-Tago M,Kasahara T

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to identify tumor suppressor genes (TSGs) in oral squamous cell carcinoma (OSCC) using whole-genome analysis of microarray technology and real-time quantitative polymerase chain reaction (QPCR). We applied whole-genome analysis of TSGs in the specimens from 3 patients of OSCC by microarray te...

journal_title：Oncology letters

authors： Ko WC,Sugahara K,Sakuma T,Yen CY,Liu SY,Liaw GA,Shibahara T

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this study was to determine the role of taxol resistance gene 1 (TXR1) in a taxol-resistant breast cancer cell line. Expression levels of TXR1 and thrombospondin-1 (TSP1) were detected by RT-PCR and Western blot analysis. In MCF-7 cells transfected with TXR1 plasmids, the expression of a number of drug ...

journal_title：Oncology letters

authors： Bai Z,Zhang Z,Qu X,Han W,Ma X

更新日期：2012-01-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) has a typical progressive course with transition from a chronic phase to a terminal blast crisis phase. The mechanisms that lead to disease progression remain to be elucidated. To understand the role of aberrant methylation in the progression of CML, DNA methylation patterns in 16 pa...

journal_title：Oncology letters

authors： Uehara E,Takeuchi S,Yang Y,Fukumoto T,Matsuhashi Y,Tamura T,Matsushita M,Nagai M,Koeffler HP,Tasaka T

更新日期：2012-01-01 00:00:00

abstract：:The present study aimed to assess the impact of post-surgical hormone replacement therapy (HRT) on life quality and prognosis in women with ovarian malignancy. HRT (Premarin, Nilestriol and medroxyprogesterone) was administered following surgery in 31 patients with ovarian cancer. A total of 44 ovarian cancer patients...

journal_title：Oncology letters

authors： Li L,Pan Z,Gao K,Zhang W,Luo Y,Yao Z,Liang X,Tang B,Li QQ

更新日期：2012-01-01 00:00:00

abstract：:We report the case of a 58-year-old male presenting with giant cell myocarditis and myositis associated with thymoma following treatment with carboplatin and paclitaxel. The patient was diagnosed as having stage IVa thymoma. Acetylcholine receptor binding antibody titers were positive at 42 nmol/l, although the patien...

journal_title：Oncology letters

authors： Sasaki H,Yano M,Kawano O,Hikosaka Y,Fujii Y

更新日期：2012-02-01 00:00:00

abstract：:Metastatic tumors in the oral cavity are rare and usually affect the jaws more often than the oral soft tissues. In particular, metastases confined to the oral mucosa are extremely rare and originate mainly from the lung and breast. Only one case restricted to the oral mucosa and originating from urinary bladder carci...

journal_title：Oncology letters

authors： Lee KS,Song IC,Yun HJ,Jo DY,Kim S,Lee HJ

更新日期：2012-02-01 00:00:00

abstract：:The receptor activator for nuclear factor κB ligand/receptor activator for nuclear factor κB (RANKL/RANK) pathway is critical for RANK-expressing cancer cells to home to bones, and c-Src is critical for cancer progression. The objective of this study was to explore the effect of c-Src in the RANKL/RANK pathway and mig...

journal_title：Oncology letters

authors： Zhang L,Teng Y,Zhang Y,Liu J,Xu L,Qu J,Hou K,Yang X,Liu Y,Qu X

更新日期：2012-02-01 00:00:00

abstract：:This pilot study analyzed and compared the presence of chromosome 8 aneusomy in Mexican women with breast cancer and adjacent, intraductal, proliferative lesions. To determine the chromosome 8 copy number, we performed fluorescence in situ hybridization in nine patients (1800 cells) who underwent mastectomy. We select...

journal_title：Oncology letters

authors： García Parra-Pérez FA,Zavala-Pompa A,Pacheco-Calleros J,Cortés-Gutiérrez EI,Cerda-Flores RM,Lara-Miranda S,Dávila-Rodríguez MI

更新日期：2012-02-01 00:00:00

abstract：:The interaction between platelets and tumor cells is critical for the hematogenous metastasis of tumor cells. We recently reported that fibrinogen was capable of bridging and enhancing the interaction of platelets and tumor cells under conditions of physical shear force. In the present study, we aimed to detect the ef...

journal_title：Oncology letters

authors： Zheng S,Liu Y,Jiao Y,Wei M,Zeng X

更新日期：2012-02-01 00:00:00

abstract：:Chromosome abnormalities in cancer cells occur early in carcinogenesis. We employed DNA probes for the detection of cancer cells in surgical specimens in Kazakh patients with suspected esophageal carcinoma, to analyze the application of this technique during the early diagnosis of esophageal cancer. Comparative analys...

journal_title：Oncology letters

authors： Awut I,Niyaz M,Biekemitoufu H,Zhang Z,Sheyhedin I,Hao W

更新日期：2012-03-01 00:00:00

abstract：:TP53 codon 72 polymorphism has been reported to affect regulatory networks central to glioma development. Although a number of published studies noted the association between TP53 codon 72 polymorphism and glioma risk, their conclusions were inconsistent. A meta-analysis was used to assess the possible association bet...

journal_title：Oncology letters

authors： Shi M,Huang R,Pei C,Jia X,Jiang C,Ren H

更新日期：2012-03-01 00:00:00

abstract：:Mutations at codons 12 and 13 of the KRAS gene have been identified as level I predictive biomarkers against the treatment of advanced colorectal cancer with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies. It is thought that the genetic analysis of KRAS mutations associated with metastatic colorect...

journal_title：Oncology letters

authors： Otsuka K,Satoyoshi R,Nanjo H,Miyazawa H,Abe Y,Tanaka M,Yamamoto Y,Shibata H

更新日期：2012-03-01 00:00:00

abstract：:In the present study, we investigated the role of matrix metalloproteinase (MMP)-2 and -9 as novel biomarkers in the body fluid of patients with metastatic breast cancer. We measured the expression of MMPs in 37 samples of body fluid (10 peritoneal and 27 pleural fluids) from metastatic breast cancer patients between ...

journal_title：Oncology letters

authors： Noh S,Jung JJ,Jung M,Kim KH,Lee HY,Wang B,Cho J,Kim TS,Jeung HC,Rha SY

更新日期：2012-03-01 00:00:00

abstract：:Docetaxel alone has been confirmed to be beneficial to patients with advanced previously treated non-small cell lung cancer (NSCLC). However, the duration and survival time is short. The study of two-agent combination regimens has important clinical significance. We conducted this randomized controlled phase II trial ...

journal_title：Oncology letters

authors： Lin Q,Meng FJ,Liu Y,Wang N,Ren XC,Chen XJ,Ge XH,Liu CX,Jing-Hu,Wang DY,Cao B,Zhao Y

更新日期：2012-04-01 00:00:00

abstract：:Hemolymphangioma is a rare, benign and non-invasive type of tumor. Only a few cases have been reported in the literature. In the present study, we report a case of hemolymphangioma growing on the left anterior chest wall of a 57-year-old woman. Physical and laboratory examinations were all normal. However, computed to...

journal_title：Oncology letters

authors： Zhang X,Sheng X,Liu F,Jian R,Li L,Luo R

更新日期：2012-04-01 00:00:00

abstract：:CD14 is the pivotal molecule in the diagnosis and therapy of CD14-associated diseases, and is important in bacteremia. The HeLa cell line is regarded as immortal due to its prolific character. The HeLa cell line is derived from human cervical cancer cells and has been widely used in cancer research and gene transfecti...

journal_title：Oncology letters

authors： Ning BT,Tang YM

更新日期：2012-04-01 00:00:00

abstract：:In the present study, an accurate and reproducible method for quantifying cell-free DNA (cfDNA) in human blood was established and tested for its ability to predict gastric cancer in patients. Using 'Alu81-qPCR' to amplify 81-bp Alu DNA sequences, we first estimated the amount of cfDNA in the serum or plasma of 130 pa...

journal_title：Oncology letters

authors： Park JL,Kim HJ,Choi BY,Lee HC,Jang HR,Song KS,Noh SM,Kim SY,Han DS,Kim YS

更新日期：2012-04-01 00:00:00

abstract：:We introduced concurrent neoadjuvant chemoradiotherapy (CCRT) with S-1, an oral fluoropyrimidine, as treatment for oral squamous cell carcinoma (OSCC) from October 2005. The clinical usefulness and medical safety of CCRT with S-1 (S-1 group) for OSCC were analyzed and compared with CCRT using super-selective intra-art...

journal_title：Oncology letters

authors： Miyawaki A,Hijioka H,Ikeda R,Ishida T,Nozoe E,Nakamura N

更新日期：2012-05-01 00:00:00

abstract：:The finding that the expression of a variant isoform of CD44 induced a metastatic phenotype in locally growing tumor cells has attracted considerable attention. A number of studies have analyzed the expression of CD44v6 in human tumors of different origins. However, the findings of these studies have been controversia...

journal_title：Oncology letters

authors： Mima K,Okabe H,Ishimoto T,Hayashi H,Nakagawa S,Kuroki H,Miyake K,Takamori H,Beppu T,Baba H

更新日期：2012-05-01 00:00:00

abstract：:The CCN3/nephroblastoma overexpressed gene belongs to the CCN family of genes that encode secreted proteins involved in a variety of processes including tumorigenesis. Altered expression of CCN3 has been observed in human nephroblastoma and renal cell carcinoma (RCC), suggesting that CCN3 plays a role in kidney tumori...

journal_title：Oncology letters

authors： Liu S,Liu Z,Bi D,Yuan X,Liu X,Ding S,Lu J,Niu Z

更新日期：2012-05-01 00:00:00

abstract：:Osteosarcoma is the most common malignant tumor of bone in childhood and adolescence. Despite intensive research for new therapies, the outcome in patients with metastasis remains extremely poor. S100 proteins are involved in the proliferation, cell cycle progression and metastasis of numerous malignant tumors, includ...

journal_title：Oncology letters

authors： Kataoka K,Ono T,Murata H,Morishita M,Yamamoto KI,Sakaguchi M,Huh NH

更新日期：2012-05-01 00:00:00

abstract：:B-type erythropoietin-producing hepatocellular (EphB) receptors and their ephrin ligands are associated with aggressive behavior and poor prognosis in a number of malignancies. The aim of this study was to determine the association between the aberrant expression of these genes and prognosis in human pancreatic cancer...

journal_title：Oncology letters

authors： Lu Z,Zhang Y,Li Z,Yu S,Zhao G,Li M,Wang Z,Wang Q,Yang Y

更新日期：2012-06-01 00:00:00

abstract：:The purpose of this study was to screen serum samples from gastric carcinoma patients and to determine whether serum amyloid A protein (SAA) served as a biomarker. SELDI technology was used to screen for changes in SAA levels in the serum samples. A mass cluster with a mass/charge (m/z) value between 11.1 and 11.9 kDa...

journal_title：Oncology letters

authors： Liu C,Pan C,Shen J,Wang H,Yong L

更新日期：2012-06-01 00:00:00

abstract：:The aim of this study was to investigate the prognostic factors and therapeutic efficacy of parotid cancer (PC). A total of 135 patients with PC who received surgical treatment were recruited between January 1985 and January 2000. There were 47 patients with poorly differentiated PC and 88 with well-differentiated PC....

journal_title：Oncology letters

authors： Shang J,Wu Y,Wang W,Wang K,Ge M

更新日期：2012-06-01 00:00:00

abstract：:Carcinosarcoma of the stomach is a rare biphasic tumor that consists of both carcinomatous and sarcomatous components. The common carcinoma component is tubular or papillary adenocarcinoma and the mesenchymal sarcomatous components are variable but may include leiomyosarcoma, rhabdomyosarcoma and osteosarcoma. The aim...

journal_title：Oncology letters

authors： Cirocchi R,Trastulli S,Desiderio J,Grassi V,Barillaro I,Santoro A,Boselli C,Avenia N,Noya G,DE Sol A

更新日期：2012-07-01 00:00:00

abstract：:In this study, we present a case of a 43-year-old female patient who was admitted to our hospital due to a giant mass on the left buttock. Imaging tests revealed that the mass was a solid-cystic tumor with a large size of 143×430×180 mm, penetrating from the pelvic cavity to the subcutaneous tissue. Pathology tests in...

journal_title：Oncology letters

authors： Zhang YF,Rao ZG,Gao JF,Xia PG,Fang DC,Zhang BC

更新日期：2012-07-01 00:00:00

abstract：:DNA double-strand break (DSB) is one of the most serious forms of damage induced by ionizing irradiation. Non-homologous end-joining (NHEJ) is a key mechanism of DNA DSB repair. The immunohistochemical analysis of proteins involved in NHEJ may have potential as a predictive assay for tumor radiosensitivity. We examine...

journal_title：Oncology letters

authors： Hayashi J,Sakata KI,Someya M,Matsumoto Y,Satoh M,Nakata K,Hori M,Takagi M,Kondoh A,Himi T,Hareyama M

更新日期：2012-07-01 00:00:00

abstract：:Lupeal acetate of Cortex periplocae (CPLA), a triterpene compound extracted from a traditional Chinese herb, has been identified as an inhibitor of cancer cell growth. The objective of the present study was to evaluate the potential mechanisms through which CPLA inhibits N-nitrosomethylbenzylamine (NMBA)-induced rat e...

journal_title：Oncology letters

authors： Wang L,Lu A,Meng F,Cao Q,Shan B

更新日期：2012-08-01 00:00:00