Serum‑derived exosomes from house dust mite‑sensitized guinea pigs contribute to inflammation in BEAS‑2B cells via the TLR4‑NF‑κB pathway.

abstract：:Chamomile is one of the most ancient medicinal herbs known to mankind. It is a member of Asteraceae/Compositae family and represented by two common varieties viz. German Chamomile (Chamomilla recutita) and Roman Chamomile (Chamaemelum nobile). The dried flowers of chamomile contain many terpenoids and flavonoids contr...

journal_title：Molecular medicine reports

authors： Srivastava JK,Shankar E,Gupta S

更新日期：2010-11-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are promising clinical tools, but the molecular mechanisms that regulate the mobilization and homing of MSCs and cause invasion through extracellular matrix (ECM) barriers are unknown. Matrix metalloproteinase (MMP) degrades the ECM and promotes cell migration. In this study, we investiga...

journal_title：Molecular medicine reports

authors： Yu Q,Chen L,You Y,Zou C,Zhang Y,Liu Q,Cheng F

更新日期：2011-01-01 00:00:00

abstract：:Myeloperoxidase (MPO) is a phase I enzyme that can bioactivate many specific procarcinogens, including polycyclic aromatic hydrocarbons and aromatic amines. The MPO gene contains a common single nucleotide polymorphism, for which the -463G>A substitution within the promoter region has been shown to reduce MPO expressi...

journal_title：Molecular medicine reports

authors： Arslan S,Pinarbasi H,Silig Y

更新日期：2011-01-01 00:00:00

abstract：:We previously identified transthyretin (TTR) and its posttranslational modifications as a down-regulated marker in mycosis fungoides (MF), a benign subtype of cutaneous T-cell lymphoma (CTCL). In order to more precisely understand the biological role of TTR in the etiology of MF, it is essential to clarify the pathway...

journal_title：Molecular medicine reports

authors： Escher N,Kob R,Kaatz M,Melle C,Hipler C,von Eggeling F

更新日期：2011-01-01 00:00:00

abstract：:Angiotensin II (ANG II) type 2 receptor (AT2R) has been recognized to suppress the proliferation of vascular smooth muscle cells (VSMCs). The aim of the present study was to determine whether AT2R overexpression inhibits neointimal hyperplasia in a rat carotid arterial balloon injury model and to examine the underlyin...

journal_title：Molecular medicine reports

authors： Tang B,Ma S,Yang Y,Yang D,Chen J,Su X,Tan Y,Sun M,Li D

更新日期：2011-03-01 00:00:00

abstract：:Several endometrial signal transducer and activator of transcription 3 (STAT3)-activating cytokines are reported to be essential for blastocyst implantation, with inhibition of STAT3 activation in the endometrium also reported to prevent implantation. To investigate STAT3 signals in endometrial epithelial cells, the a...

journal_title：Molecular medicine reports

authors： Tanaka T,Bai T,Utsunomiya H,Fukumoto T,Yukawa K

更新日期：2011-03-01 00:00:00

abstract：:It has been found that certain cytokines (IL-4, IL-10 and TGF-β1) are highly expressed locally in biopsies from patients with premalignant lesions and cervical cancer, and may induce a local immune-suppression state. In particular, IL-10 is highly expressed in tumor cells and its expression is directly proportional to...

journal_title：Molecular medicine reports

authors： Bermúdez-Morales VH,Peralta-Zaragoza O,Alcocer-González JM,Moreno J,Madrid-Marina V

更新日期：2011-03-01 00:00:00

abstract：:Gut-derived endotoxin and pathogenic bacteria have been proposed to be important causative factors of morbidity and mortality due to heat stroke. However, the molecular mechanisms underlying the small intestinal lesions caused by heat stroke have yet to be well characterized. In order to verify the possible inflammato...

journal_title：Molecular medicine reports

authors： Liu Z,Sun X,Tang J,Tang Y,Tong H,Wen Q,Liu Y,Su L

更新日期：2011-05-01 00:00:00

abstract：:Emodin has been demonstrated to inhibit the fibrotic process in chronic renal disease, but its mechanisms have yet to be fully elucidated. This study was carried out to investigate the effects of emodin on extracellular matrix (ECM) synthesis in TGF-β1-stimulated NRK-49F cells. NRK-49F cells stimulated with TGF-β1 wer...

journal_title：Molecular medicine reports

authors： Zhu B,Lin Y,Zhu CF,Zhu XL,Huang CZ,Lu Y,Cheng XX,Wang YJ

更新日期：2011-05-01 00:00:00

abstract：:Hyperpolarization-activated current (If) is the major ionic current contributing to the spontaneous diastolic depolarization of cardiac sinus node pacemaker cells. It is mediated by hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels. However, several observations support a potential role of HCN cha...

journal_title：Molecular medicine reports

authors： Song T,Yang J,Yao Y,Li H,Chen Y,Zhang J,Huang C

更新日期：2011-05-01 00:00:00

abstract：:Sinomenine (SIN) is an herbal ingredient isolated from Sinomenium acutum Rehd. et Wils. We evaluated the effects of SIN on the growth and apoptosis of human lung cancer NCI-H460 cells. SIN inhibited the proliferation of the cells in a dose- and time-dependent manner. Apoptosis was confirmed by flow cytometry, the TUNE...

journal_title：Molecular medicine reports

authors： Jiang T,Zhou L,Zhang W,Qu D,Xu X,Yang Y,Li S

更新日期：2010-01-01 00:00:00

abstract：:Potent antiviral agents hinder virus-infected cell machinery, leading to rescue from viral damage. In this study, we aimed to identify selective intracellular glycosylation inhibitor(s) that do not suppress glycoprotein synthesis. Our results showed that nonactin is a potent inhibitor of intracellular glycosylation. F...

journal_title：Molecular medicine reports

authors： Lee JM,Kim JG,Kim TH,Lee DS,Kim JH,Cho SK,Riu KZ,Lee DS,Lee SH

更新日期：2010-01-01 00:00:00

abstract：:The present study investigated the growth of human fibrosarcoma (HT-1080) and fibroblast (SF-TY) cells in combination with water-soluble (WS) and high molecular component (HMC) fractions prepared from Reishi (R), Rokkaku-Reishi (2R) and Apple Rokkaku-Reishi (A2R). Each WS fraction exhibited dose-and time-dependent inh...

journal_title：Molecular medicine reports

authors： Katagata Y,Sasaki F

更新日期：2010-01-01 00:00:00

abstract：:Leukotrienes (LTs) are biologically active fatty acids derived from the oxidative metabolism of arachidonic acid through the 5-lipoxygenase pathway. LTs work to contract airway smooth muscle, increase vascular permeability and mucus secretions, and attract and activate inflammatory cells in the airways of patients wit...

journal_title：Molecular medicine reports

authors： Matsuyama M,Yoshimura R

更新日期：2010-03-01 00:00:00

abstract：:Currently available anticancer drugs are cytotoxic to normal as well as to neoplastic cells, therefore the synthesis of β-lactams as new and novel anticancer agents is extremely significant. We previously developed synthetic methods for the preparation of β-lactams and anticancer agents resulting from polyaromatic ami...

journal_title：Molecular medicine reports

authors： Banik BK,Becker FF

更新日期：2010-03-01 00:00:00

abstract：:Chronic hepatitis C (HCV) infection persists in more than 170 million people worldwide and is one of the major causes of hepatic failure and liver transplantation. Current treatment of chronic HCV, consisting of pegylated interferon and ribavirin, is associated with a wide range of side effects, contraindications and ...

journal_title：Molecular medicine reports

authors： Grüngreiff K,Reinhold D

更新日期：2010-05-01 00:00:00

abstract：:The cellular origin of soft tissue sarcomas (STSs) is not fully understood. The cancer stem cell hypothesis presumes that tumors originate from the malignant transformation of stem cells. As a type of multipotent stem cell, adipose tissue-derived stromal/stem cells (ADSCs), which possess an unexpected degree of plasti...

journal_title：Molecular medicine reports

authors： Chen H,Zhang S,Wen JC,Zheng JK,Chen Q,Li WY,Wang PP,Ma L,Huang TH,Huang G,Yang LY

更新日期：2010-05-01 00:00:00

abstract：:Calcineurin and its downstream effectors nuclear factor of activated T-cells 3 (NFAT3) and zinc finger-containing transcription factor (GATA4) have been implicated in the development of cardiac hypertrophy. The aims of the present study were to investigate alterations in the calcineurin/NFAT3/GATA4 pathway in pressure...

journal_title：Molecular medicine reports

authors： Yang D,Ma S,Tan Y,Li D,Tang B,Chen J,Su X,Li G,Zhang X,Yang Y

更新日期：2010-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) is one of the most common blood-borne pathogens transmitted from patients to health-care workers (HCWs). HCV infection status among HCWs and occupational blood exposure accidents were monitored to assess the risk of HCV infection among 403 HCWs from a single institution between 1999 and 2009. A...

journal_title：Molecular medicine reports

authors： Marconi A,Candido S,Talamini R,Libra M,Nicoletti F,Spandidos DA,Stivala F,Proietti L

更新日期：2010-07-01 00:00:00

abstract：:To investigate the apoptotic effects of an extract of red-tide algae, Protoceratium reticulatum, on HeLa cells, we used liquid chromatography-tandem mass spectrometry, optical microscopy, Hoechst 33342/propidine iodide staining, and DNA gel electrophoresis to analyze its constituents and toxicity, as well as rhodamine...

journal_title：Molecular medicine reports

authors： Pang M,Gao CL,Wu ZX,Lv N,Wang ZL,Tang XX,Qu P

更新日期：2010-07-01 00:00:00

abstract：:Serum albumin exists in oxidized and reduced forms. Although the oxidation of albumin affects some of its functions, the relationship between oxidized albumin and colloid osmotic pressure (COP) remains unclear. The aim of this study was to determine whether there is an association between oxidized albumin and COP. Blo...

journal_title：Molecular medicine reports

authors： Sakata M,Kawaguchi T,Taniguchi E,Nakayama A,Ishizaki S,Sonaka I,Maganuma M,Nakamura T,Itou M,Oriishi T,Abe M,Yanagimoto C,Koga H,Harada M,Sakamoto T,Oda S,Sata M

更新日期：2010-07-01 00:00:00

abstract：:Prostate apoptosis response-4 (Par-4) is a tumor-suppressor protein that induces apoptosis in cancer cells, but not in normal cells. The cancer-specific pro-apoptotic action of Par-4 is encoded in its centrally located SAC domain. In this study, to further enhance the anti-cancer effect of Par-4 in order to overcome t...

journal_title：Molecular medicine reports

authors： Qin TJ,Ma W,Liu SX,Yang GX,Wang QY,Zhao XH

更新日期：2010-09-01 00:00:00

abstract：:The intracellular actin cytoskeleton is a central player in tumor cell migration and adhesion, and interacts with the extracellular matrix during the progression to metastasis. Although recent reports on motility events have revealed that the destabilization of actin affects cancer progression and hypoxia inducible fa...

journal_title：Molecular medicine reports

authors： Shin IJ,Park BK,Ahn YT,Kim Y,An WG

更新日期：2010-09-01 00:00:00

abstract：:The nuclear phosphoprotein DEK is abundantly present in cells and is implicated in diseases including leukemia and autoimmune disorders. DEK has three highly acidic amino acid domains and inhibits histone acetyltransferase activity by binding directly to histones. In a previous study, differentially regulated proteins...

journal_title：Molecular medicine reports

authors： Kim DW,Kim JY,Choi S,Rhee S,Hahn Y,Seo SB

更新日期：2010-09-01 00:00:00

abstract：:The heat shock protein 27-kDa (HSP27) has been found overexpressed in several types of human cancer and is associated with treatment resistance and poor prognosis. Recent proteomic studies demonstrate that HSP27 is significantly overexpressed in colorectal cancer (CRC). However, the relationship between HSP27 expressi...

journal_title：Molecular medicine reports

authors： Yu Z,Zhi J,Peng X,Zhong X,Xu A

更新日期：2010-11-01 00:00:00

abstract：:Allyl isothiocyanate (AITC) is a constituent of cruciferous vegetables that exhibits antitumor activity. In this study, AITC was shown to inhibit the proliferation of human metastatic colorectal adenocarcinoma SW620 cells in vitro by inducing cell cycle arrest at the G2/M phase. The signaling pathway of AITC action in...

journal_title：Molecular medicine reports

authors： Lau WS,Chen T,Wong YS

更新日期：2010-11-01 00:00:00

abstract：:The aim of the present study was to examine whether crude glycosphingolipid (cGSL) has short-term chemopreventive effects on the preneoplastic biomarker lesions involved in carcinogen-induced rat colon carcinogenesis. We also examined whether cGSL affects cell proliferation and apoptosis in these lesions. The crude pr...

journal_title：Molecular medicine reports

authors： Sunagawa N,Inamine M,Morioka T,Chiba I,Morita N,Aoki Y,Suzui M,Yoshimi N

更新日期：2009-01-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related death in Taiwan. In the clinical treatment of lung cancer patients in Asia, an Astragalus-based herbal mixture is commonly used in conjunction with chemotherapy. The principal component of Astragalus (also known as Huang-qi) is Astragaloside IV. The Astragaloside IV m...

journal_title：Molecular medicine reports

authors： Su CC,Chiou TL,Chan MH,Lin JG

更新日期：2009-01-01 00:00:00

abstract：:Biomarkers for the early detection of liver toxicity are crucial in drug development for assessing the safety of a new drug. Oxidation reduction potential (ORP) is an overall measure of the oxidative stress to which a biological component is subjected and correlates with organ dysfunction. Raman spectroscopy is a non-...

journal_title：Molecular medicine reports

authors： Bar-Or R,Rael LT,Curtis CG,Mains CW,Slone DS,Bar-Or D

更新日期：2009-03-01 00:00:00

abstract：:The translocation t(9;11)(p22;q23) generates the MLL-AF9 oncogene and is commonly associated with monocytic acute myeloid leukemia (AML-M5; FAB-classification). For the oncogenicity of MLL-AF9, the (over)expression of several other genes, including selected HOXA cluster genes as well as MEIS1 (a HOX cofactor), is requ...

journal_title：Molecular medicine reports

authors： Martino V,Bianchera A,Reia L,Bussolati O,Fazzina R,Marino F,Montemurro L,Tonelli R,Pession A,Gazzola GC,Sala R

更新日期：2009-03-01 00:00:00