Giant chondroid lipoma of the breast: A case report and literature review.

abstract：:The aim of the study was to investigate the functional mechanisms of osteopontin (Opn) and chemokine-like factor 1 (Cklf1) during the development and progression of abdominal aortic aneurysms (AAA) in rats. Healthy adult Sprague-Dawley rats (n=30) were randomly divided into the AAA, control and sham groups (10 rats/gr...

journal_title：Experimental and therapeutic medicine

authors： Li J,Bao X,Li Y,Wang Y,Zhao Z,Jin X

更新日期：2016-12-01 00:00:00

abstract：:Oxidative stress is the principal factor in traumatic brain injury (TBI) that initiates protracted neuronal dysfunction and remodeling. Cytoskeletal proteins are known to be carbonylated under oxidative stress; however, the complex molecular and cellular mechanisms of cytoskeletal protein carbonylation remain poorly u...

journal_title：Experimental and therapeutic medicine

authors： Zhang Q,Zhang M,Huang X,Liu X,Li W

更新日期：2016-12-01 00:00:00

abstract：:We aimed to explore the feasibility and the safety of the laparoscopic surgery for incarcerated indirect inguinal hernia (IIH) in children. From January 2012 to December 2014, 64 children were enrolled into this study. All 64 patients received laparoscopic surgery and we reviewed their perioperative and postoperative ...

journal_title：Experimental and therapeutic medicine

authors： Yin Y,Zhang H,Zhang X,Sun F,Zou H,Cao H,Wen C

更新日期：2016-12-01 00:00:00

abstract：:The aim of the present study was to examine the effect of lamotrigine and the expression of myeloid-related protein 8 (MRP8) and interleukin-7 (IL-7) in the treatment of focal cortical dysplasia with secondary intractable epilepsy. In this study, rats with focal cortical dysplasia with secondary intractable epilepsy (...

journal_title：Experimental and therapeutic medicine

authors： Wei J,Nie Q,Li F

更新日期：2016-12-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of Ginseng polysaccharides (GPS) on natural killer (NK) cell cytotoxicity in immunosuppressed mice. Cyclophosphamide (Cy) was used to construct an immunosuppressed mouse model. The mice in each group were submitted to gavages with 200 or 400 mg/kg GPS every d...

journal_title：Experimental and therapeutic medicine

authors： Sun Y,Guo M,Feng Y,Zheng H,Lei P,Ma X,Han X,Guan H,Hou D

更新日期：2016-12-01 00:00:00

abstract：:The clinical efficacy and safety of different combinations of non-bio artificial liver in the treatment of acute liver failure was examined. A total of 61 cases were selected under blood purification treatment from the patients with severe acute liver failure admitted to the severe disease department of the hospital f...

journal_title：Experimental and therapeutic medicine

authors： Li M,Sun J,Li J,Shi Z,Xu J,Lu B,Cheng S,Xu Y,Wang X,Zhang X

更新日期：2016-12-01 00:00:00

abstract：:Acute fibrinous and organizing pneumonia (AFOP) is a rare lung disease with distinct histological characteristics that include the diffuse presence of intra-alveolar fibrin, and the absence of eosinophils and hyaline membrane. In the present study, a case of AFOP that was diagnosed by lung biopsy is described. The pat...

journal_title：Experimental and therapeutic medicine

authors： Xu XY,Chen F,Chen C,Sun HM,Zhao BL

更新日期：2016-12-01 00:00:00

abstract：:Intake of a high dosage of baicalin has previously been shown to attenuate hyperlipidemia induced by a high-fat diet. Baicalin functions as an activator of peroxisome proliferator-activated receptor-γ (PPAR-γ), which is the key regulator of reverse cholesterol transport (RCT). The present study aimed to test the hypot...

journal_title：Experimental and therapeutic medicine

authors： Yu R,Lv Y,Wang J,Pan N,Zhang R,Wang X,Yu H,Tan L,Zhao Y,Li B

更新日期：2016-12-01 00:00:00

abstract：:Heart disease-related deaths are the highest in most societies and congenital heart diseases account for approximately 40% of prenatal deaths and over 20% of mortality in the first few months after birth. Congenital heart disease affects approximately 1% of all newborns and is the causative factor for more deaths with...

journal_title：Experimental and therapeutic medicine

authors： Tian J,An X,Niu L

更新日期：2017-01-01 00:00:00

abstract：:The aim of the present study was to examine hypoxia-inducible factor 1α (HIF-1α) levels in the synovial fluid and articular cartilage of patients with primary knee osteoarthritis (OA) and to investigate their association with the severity of disease. A total of 36 patients with knee OA and ten healthy controls were en...

journal_title：Experimental and therapeutic medicine

authors： Qing L,Lei P,Liu H,Xie J,Wang L,Wen T,Hu Y

更新日期：2017-01-01 00:00:00

abstract：:An Indian study recently observed three new loci: rs9552911 in the SGCG, rs1593304 near PLXNA4 and rs4858889 in SCAP associated with type 2 diabetes mellitus (T2DM) in a south Asian population. The present study aimed to validate these findings in a Chinese population. We genotyped the above three single-nucleotide po...

journal_title：Experimental and therapeutic medicine

authors： Chen M,Zhang X,Fang Q,Wang T,Li T,Qiao H

更新日期：2017-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the treatment effects of BeauTop in alopecia by observing its effectiveness in improving androgenetic alopecia. Hair growth was observed using a dermatoscope and clinical photos, and was scored by three dermatologists. Dermatologists evaluated and selected suitable particip...

journal_title：Experimental and therapeutic medicine

authors： Lee CY,Wei CC,Yu MC,Lin CC,Sheu SJ,Yang JH,Chiang CY,Huang KH,Kuan YH

更新日期：2017-01-01 00:00:00

abstract：:Stroke is one of the leading causes of mortality worldwide. Protective agents that can diminish injuries caused by cerebral ischemia-reperfusion (I/R) are important in alleviating the harmful outcomes of stroke. The aim of the present study was to investigate the protective role of sanguinarine in cerebral I/R injury....

journal_title：Experimental and therapeutic medicine

authors： Wang Q,Dai P,Bao H,Liang P,Wang W,Xing A,Sun J

更新日期：2017-01-01 00:00:00

abstract：:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease. The pathogenesis of CRSwNP remains unclear. This study was designed to investigate the role of inflammation and Staphylococcus aureus enterotoxin (SE) in this disease. The study included a total of 74 patients with CRSwNP and 6 controls. A ...

journal_title：Experimental and therapeutic medicine

authors： Cheng KJ,Wang SQ,Xu YY

更新日期：2017-01-01 00:00:00

abstract：:The present study aimed to investigate the effects of asiaticoside (AS) on the pathology and associated mechanisms of β-amyloid (Aβ)-induced Alzheimer's disease (AD) in rats. An AD rat model was established by lateral intracerebroventricular injection of Aβ 1-42 oligomers. Learning and memory function were evaluated b...

journal_title：Experimental and therapeutic medicine

authors： Zhang Z,Li X,Li D,Luo M,Li Y,Song L,Jiang X

更新日期：2017-02-01 00:00:00

abstract：:The aim of the current study was to demonstrate the distribution of VEGFR-2 on glioma microvascular endothelial cells on a nanoscale and investigate changes in VEGFR-2 activity following treatment with the VEGFR-2 inhibitor and agonist sorafenib and bradykinin, respectively. Three groups were evaluated in this study: ...

journal_title：Experimental and therapeutic medicine

authors： Zhou D,Zhan S,Zhou D,Wang P,Chen G,Qin K,Lin X

更新日期：2017-02-01 00:00:00

abstract：:The aim of this study was to explore an effective method for the repair of cartilage defects using chitosan/glycerophosphate (C/GP) gel- and Matrigel-engineered human bone morphogenetic protein 7 (hBMP7)-expressing chondrocytes. Rabbit chondrocytes were obtained, cultured in vitro and transfected with an adenovirus co...

journal_title：Experimental and therapeutic medicine

authors： Xia X,Li J,Xia B,Yang H,Zhang D,Zhou B,Zhang J,Zhou M,Liu F

更新日期：2017-02-01 00:00:00

abstract：:Anabolic androgenic steroids (AAS) are performance-enhancing drugs commonly abused by atheletes. Stanozolol is a synthetic testosterone-derived anabolic steroid. Although it is well known that AAS have several side-effects, there are only few toxicological studies available on the toxic effects and mechanisms of actio...

journal_title：Experimental and therapeutic medicine

authors： Kara M,Ozcagli E,Fragkiadaki P,Kotil T,Stivaktakis PD,Spandidos DA,Tsatsakis AM,Alpertunga B

更新日期：2017-02-01 00:00:00

abstract：:Steroids are known to inhibit osteogenic differentiation and decrease bone formation in mesenchymal stem cells (MSCs), while concomitantly inducing steroid-induced avascular necrosis of the femoral head (SANFH). The aim of the present study was to evaluate the function of MSCs on differentiation in SANFH and investiga...

journal_title：Experimental and therapeutic medicine

authors： Wang T,Teng S,Zhang Y,Wang F,Ding H,Guo L

更新日期：2017-02-01 00:00:00

abstract：:The aim of the present study was to evaluate whether the ratio of the absolute number of platelets to the number of lymphocytes (PLR) correlates with the severity of coronary artery disease (CAD) and major adverse cardiovascular disease (CVD) events in Chinese patients with CAD. PLR was calculated as follows: PLR=plat...

journal_title：Experimental and therapeutic medicine

authors： Zhou D,Wang G,Fan Y,Wan Z,Liu X

更新日期：2017-02-01 00:00:00

abstract：:The present study aimed to analyze the association of transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) expression levels in skeletal muscle with the clinical manifestation of Duchenne muscular dystrophy (DMD). A total of 18 cases of DMD, which were confirmed by routine pathological dia...

journal_title：Experimental and therapeutic medicine

authors： Song Y,Yao S,Liu Y,Long L,Yang H,Li Q,Liang J,Li X,Lu Y,Zhu H,Zhang N

更新日期：2017-04-01 00:00:00

abstract：:The aim of the present study was to determine the repairing effects of intercellular adhesion molecule (ICAM)-1-expressing mesenchymal stem cells (MSCs) in mice with autoimmune thyroiditis. Following induction of an experimental autoimmune thyroiditis (EAT) model, mice were randomly divided into the following groups (...

journal_title：Experimental and therapeutic medicine

authors： Ma S,Chen X,Wang L,Wei Y,Ni Y,Chu Y,Liu Y,Zhu H,Zheng R,Zhang Y

更新日期：2017-04-01 00:00:00

abstract：:The effects of inhaled and intravenous application of a guanylate cyclase stimulator (BAY 41-8543) on pulmonary vascular resistance (PVR) and cardiac output (CO) were investigated in an experimental model of septic shock. Following induction of septic shock, anaesthetized pigs (n=31) were randomly place into two group...

journal_title：Experimental and therapeutic medicine

authors： Kronas N,Peters B,Richter HP,Goetz AE,Kubitz JC

更新日期：2017-04-01 00:00:00

abstract：:Influenza A (H1N1) caused its first pandemic in 2009 in USA and Mexico. Since then, clinicians have exercised great care in order to make an early diagnosis of viral pneumonias. This is due in part to pandemic influenza A infection having greater impact on populations <65 years old than other viral strains, including ...

journal_title：Experimental and therapeutic medicine

authors： Çörtük M,Acat M,Yazici O,Yasar Z,Kiraz K,Ataman SY,Tanriverdi E,Zitouni B,Kirakli C,Ediboglu O,Tuksavul F,Dirican A,Celik HK,Ozkaya S,Cetinkaya E

更新日期：2017-04-01 00:00:00

abstract：:Familial adenomatous polyposis (FAP; Mendelian of Inherintance in Man ID, 175100) is a rare autosomal dominant disorder characterized by the development of numerous adenomatous polyps throughout the colon and rectum associated with an increased risk of colorectal cancer. FAP is at time accompanied with certain extrain...

journal_title：Experimental and therapeutic medicine

authors： Li H,Zhang L,Jiang Q,Shi Z,Tong H

更新日期：2017-04-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of human papillomavirus (HPV) infection on the gynecological disease of vaginitis and to demonstrate how the small interfering RNA (siRNA) method may be used for HPV prevention in the clinic. Human vaginal epithelial cells were transfected with HPV-11 L1 expr...

journal_title：Experimental and therapeutic medicine

authors： Zeng J,Yang S,Wang X,Gao Y,Zhang M

更新日期：2017-04-01 00:00:00

abstract：:The present study aimed to investigate the effects of lipoprotein-associated phospholipase A2 (Lp-PLA2) on endothelial dysfunction in an in vitro cell model of atherosclerosis, and to determine whether AMP-activated protein kinase (AMPK) mediates the effects of Lp-PLA2 on endothelial dysfunction. A total of 392 patien...

journal_title：Experimental and therapeutic medicine

authors： Yang L,Cong HL,Wang SF,Liu T

更新日期：2017-04-01 00:00:00

abstract：:The density and properties of ion channels in the injured axon and dorsal root ganglion (DRG) neuronal soma membrane change following nerve injury, which may result in the development of neuropathic pain. Gabapentin (GBP) is a drug for the first-line treatment of neuropathic pain. One of its therapeutic targets is the...

journal_title：Experimental and therapeutic medicine

authors： Zhu M,Sun X,Chen X,Xiao H,Duan M,Xu J

更新日期：2017-03-01 00:00:00

abstract：:The value of cone beam breast computed tomography (CBBCT) imaging on covered areas of breast tissue, which is the relation between imaging quality and CT dose were studied. Multi-energy spectrum was used to radiate same-size built-in calcifications and lump breast motifs under the condition of the same number of parti...

journal_title：Experimental and therapeutic medicine

authors： Xu M,Cheng X,Cheng X,Lan X,Chen S,Ji J

更新日期：2017-03-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. It affects the locomotor system, leading to a final severe disability through degeneration of dopaminergic neurons. Despite several therapeutic approaches used, no treatment has been proven to be effective; however, cell therapy ma...

journal_title：Experimental and therapeutic medicine

authors： Salama M,Sobh M,Emam M,Abdalla A,Sabry D,El-Gamal M,Lotfy A,El-Husseiny M,Sobh M,Shalash A,Mohamed WM

更新日期：2017-03-01 00:00:00