17β-Estradiol activates Cl- channels via the estrogen receptor α pathway in human thyroid cells.

abstract：:A large number of ion channels maintain their activity through direct interactions with phosphatidylinositol bisphosphate (PIP2). For such channels, hydrolysis of PIP2 causes current inhibition. It has become controversial whether the inhibitory effects on channel activity represent direct effects of PIP2 hydrolysis o...

journal_title：Channels (Austin, Tex.)

authors： Keselman I,Fribourg M,Felsenfeld DP,Logothetis DE

更新日期：2007-03-01 00:00:00

abstract：:Inward rectifier K(+) (Kir) channels are expressed in multiple neuronal and glial cells. Recent studies have equated certain properties of exogenously expressed Kir4.1 channels with those of native K(+) currents in brain cells, as well as demonstrating the expression of Kir4.1 subunits in these tissues. There are nagg...

journal_title：Channels (Austin, Tex.)

authors： Kucheryavykh YV,Pearson WL,Kurata HT,Eaton MJ,Skatchkov SN,Nichols CG

更新日期：2007-05-01 00:00:00

abstract：:Mice with genetic inhibition (AC3-I) of the multifunctional Ca(2+)/calmodulin dependent protein kinase II (CaMKII) have improved cardiomyocyte survival after ischemia. Some K(+) currents are up-regulated in AC3-I hearts, but it is unknown if CaMKII inhibition increases the ATP sensitive K(+) current (I(KATP)) that und...

journal_title：Channels (Austin, Tex.)

authors： Li J,Marionneau C,Koval O,Zingman L,Mohler PJ,Nerbonne JM,Anderson ME

更新日期：2007-09-01 00:00:00

abstract：:Glutamate transporters are unusual proteins in that they can function as both a transporter and a chloride channel. With the recent determination of the crystal structure of an archaeal aspartate transporter it is now possible to begin to put together a physical picture of how these proteins are able to carry out thei...

journal_title：Channels (Austin, Tex.)

authors： Vandenberg RJ,Huang S,Ryan RM

更新日期：2008-01-01 00:00:00

abstract：:The muO-conotoxins MrVIA and MrVIB are 31-residue peptides from Conus marmoreus, belonging to the O-superfamily of conotoxins with three disulfide bridges. They have attracted attention because they are inhibitors of tetrodotoxin-insensitive voltage-gated sodium channels (Na(V)1.8) and could therefore serve as lead st...

journal_title：Channels (Austin, Tex.)

authors： Leipold E,DeBie H,Zorn S,Borges A,Olivera BM,Terlau H,Heinemann SH

更新日期：2007-07-01 00:00:00

abstract：:How many different calcium channels does it take to make a nervous system? The answer: more than any of us predicted. In 1975 Hagiwara and colleagues published the first evidence that functionally different calcium channels are expressed in cells. By 1999, the calcium channel family could boast ten members, each membe...

journal_title：Channels (Austin, Tex.)

authors： Lipscombe D,Raingo J

更新日期：2007-07-01 00:00:00

abstract：:Regulated trafficking of AMPA receptors (AMPARs) is an important mechanism that underlies the activity-dependent modification of synaptic strength. Trafficking of AMPARs is regulated by specific interactions of their subunits with other proteins. Recently, we have reported that the AMPAR subunit GluR1 binds the cGMP-d...

journal_title：Channels (Austin, Tex.)

authors： Serulle Y,Arancio O,Ziff EB

更新日期：2008-07-01 00:00:00

abstract：:TRPA1 is a member of the transient receptor potential (TRP) cation channel family, and is predominantly expressed in nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia. Activation of TRPA1 by environmental irritants such as mustard oil, allicin and acrolein causes acute pain. However, the endogeno...

journal_title：Channels (Austin, Tex.)

authors： Takahashi N,Mizuno Y,Kozai D,Yamamoto S,Kiyonaka S,Shibata T,Uchida K,Mori Y

更新日期：2008-07-01 00:00:00

abstract：:RNA editing revises the genetic code at precise locations, creating single base changes in mRNA. These changes can result in altered coding potential and modifications to protein function. Sequence analysis of the Shab potassium channel of Drosophila melanogaster revealed five such RNA editing sites. Four are constitu...

journal_title：Channels (Austin, Tex.)

authors： Ryan MY,Maloney R,Reenan R,Horn R

更新日期：2008-05-01 00:00:00

abstract：:Ion channels play a central role in the normal electro-mechanical functioning of the heart and are implicated in a variety of disease processes. In response to electrical or mechanical perturbations, cardiac myocytes exhibit remarkable changes in the expression and/or the function of sarcolemmal ion channels, a proces...

journal_title：Channels (Austin, Tex.)

authors： Marrus SB,Nerbonne JM

更新日期：2008-03-01 00:00:00

abstract：:Co-assembly of KCNQ1 with different accessory, or beta, subunits that are members of the KCNE family results in potassium (K+) channels that conduct functionally distinct currents. The alpha subunit KCNQ1 conducts a slowly activated delayed rectifier K+ current (IKs), a major contributor to cardiac repolarization, whe...

journal_title：Channels (Austin, Tex.)

authors： Kurokawa J,Bankston JR,Kaihara A,Chen L,Furukawa T,Kass RS

更新日期：2009-01-01 00:00:00

abstract：:Inward rectifier K+ (Kir) channels can be functionally categorized into two groups: those that are constitutively active and those that are constitutively inactive, with examples such as Kir2.x and Kir3.x, respectively. Their cytoplasmic regions are thought to be critical for control of channel gating, but a structura...

journal_title：Channels (Austin, Tex.)

authors： Inanobe A,Matsuura T,Nakagawa A,Kurachi Y

更新日期：2007-01-01 00:00:00

abstract：:The renal inward rectifying potassium channel Kir1.1 plays key roles in regulating electrolyte homeostasis and blood pressure. Loss-of-function mutations in the channel cause a life-threatening salt and water balance disorder in infants called antenatal Bartter syndrome (ABS). Of more than 30 ABS mutations identified,...

journal_title：Channels (Austin, Tex.)

authors： Fallen K,Banerjee S,Sheehan J,Addison D,Lewis LM,Meiler J,Denton JS

更新日期：2009-01-01 00:00:00

abstract：:The stress reaction includes the release of stress hormones such as cortisol via the HPA axis4. One of the genes regulated by cortisol is the serum- and glucocorticoid-inducible kinase 1 (SGK1) a stimulator of the slow outward potassium channel KCNQ1/KCNE1-one of the major mediators of cardiac repolarization. Apart fr...

journal_title：Channels (Austin, Tex.)

authors： Strutz-Seebohm N,Henrion U,Steinke K,Tapken D,Lang F,Seebohm G

更新日期：2009-03-01 00:00:00

abstract：:Previously we have shown that the transient receptor potential vanilloid 4 (TRPV4) channel regulates urinary bladder function, and that TRPV4 is expressed in both smooth muscle and urothelial cell types within the bladder wall.(1) Urothelial cells have also been suggested to express TRPV1 channels.(2) Therefore, we en...

journal_title：Channels (Austin, Tex.)

authors： Xu X,Gordon E,Lin Z,Lozinskaya IM,Chen Y,Thorneloe KS

更新日期：2009-05-01 00:00:00

abstract：:Accumulating evidence indicate that the gap-junction inhibitor carbenoxolone (CBX) regulates neuronal synchronization, depresses epileptiform activity and has a neuroprotective action. These CBX effects do not depend solely on its ability to inhibit gap junction channels formed by connexins (Cx), but the underlying me...

journal_title：Channels (Austin, Tex.)

authors： Benfenati V,Caprini M,Nicchia GP,Rossi A,Dovizio M,Cervetto C,Nobile M,Ferroni S

更新日期：2009-09-01 00:00:00

abstract：:Auxiliary beta subunits are critical determinants of membrane expression and gating properties of voltage-gated calcium channels. Mutations in the beta(4) subunit gene cause ataxia and epilepsy. However, the specific function of beta(4) in neurons and its causal relation to neurological diseases are unknown. Here we r...

journal_title：Channels (Austin, Tex.)

authors： Subramanyam P,Obermair GJ,Baumgartner S,Gebhart M,Striessnig J,Kaufmann WA,Geley S,Flucher BE

更新日期：2009-09-01 00:00:00

abstract：:Voltage-gated potassium channels are often assembled with accessory proteins that increase their functional diversity. KCNE proteins are small accessory proteins that modulate voltage-gated potassium (K(V)) channels. Although the functional effects of various KCNE proteins have been described, many questions remain re...

journal_title：Channels (Austin, Tex.)

authors： Vanoye CG,Welch RC,Tian C,Sanders CR,George AL Jr

更新日期：2010-03-01 00:00:00

abstract：:The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a cyclic AMP-regulated chloride channel that plays an important role in regulating the volume of the lung airway surface liquid, and thereby mucociliary clearance and elimination of pathogens from the lung. In epithelial cells, cell surface CFTR abundan...

journal_title：Channels (Austin, Tex.)

authors： Bomberger JM,Barnaby RL,Stanton BA

更新日期：2010-05-01 00:00:00

abstract：:AMPA receptors mediate the majority of fast synaptic transmission in the central nervous system and are therefore among the most intensively studied ligand-gated ion channels over the last decades. However, the recent discovery that native AMPA receptor complexes contain auxiliary subunits classified as transmembrane ...

journal_title：Channels (Austin, Tex.)

authors： Sager C,Tapken D,Hollmann M

更新日期：2010-05-01 00:00:00

abstract：:The Rem, Rem2, Rad, and Gem/Kir (RGK) GTPases, comprise a subfamily of small Ras-related GTP-binding proteins, and have been shown to potently inhibit high voltage-activated Ca(2+) channel current following overexpression. Although the molecular mechanisms underlying RGK-mediated Ca(2+) channel regulation remains cont...

journal_title：Channels (Austin, Tex.)

authors： Pang C,Crump SM,Jin L,Correll RN,Finlin BS,Satin J,Andres DA

更新日期：2010-05-01 00:00:00

abstract：:Retinal ganglion cell (RGC) degeneration is an important cause of visual impairment, and results in part from microglia-mediated inflammation. Numerous experimental studies have focused on identifying drug targets to rescue these neurons. We recently showed that K(V)1.1 and K(V)1.3 channels are expressed in adult rat ...

journal_title：Channels (Austin, Tex.)

authors： Koeberle PD,Schlichter LC

更新日期：2010-09-01 00:00:00

abstract：:Several inwardly-rectifying (Kir) potassium channels (Kir1.1, Kir4.1 and Kir4.2) are characterised by their sensitivity to inhibition by intracellular H(+) within the physiological range. The mechanism by which these channels are regulated by intracellular pH has been the subject of intense scrutiny for over a decade,...

journal_title：Channels (Austin, Tex.)

authors： Paynter JJ,Shang L,Bollepalli MK,Baukrowitz T,Tucker SJ

更新日期：2010-09-01 00:00:00

abstract：:Gating transitions in the K(V)4.3 N-terminal deletion mutant Δ2-39 were characterized in the absence and presence of KChIP2b. We particularly focused on gating characteristics of macroscopic (open state) versus closed state inactivation (CSI) and recovery. In the absence of KChIP2b Δ2-39 did not significantly alter th...

journal_title：Channels (Austin, Tex.)

authors： Hovind LJ,Skerritt MR,Campbell DL

更新日期：2011-01-01 00:00:00

abstract：:Voltage-gated L-type calcium channels (LTCCs) are expressed in adrenal chromaffin cells. Besides shaping the action potential (AP), LTCCs are involved in the excitation-secretion coupling controlling catecholamine release and in Ca (2+) -dependent vesicle retrieval. Of the two LTCCs expressed in chromaffin cells (CaV1...

journal_title：Channels (Austin, Tex.)

authors： Comunanza V,Marcantoni A,Vandael DH,Mahapatra S,Gavello D,Carabelli V,Carbone E

更新日期：2010-11-01 00:00:00

abstract：:Voltage-gated calcium channels (CaVs) are large, transmembrane multiprotein complexes that couple membrane depolarization to cellular calcium entry. These channels are central to cardiac action potential propagation, neurotransmitter and hormone release, muscle contraction, and calcium-dependent gene transcription. Ov...

journal_title：Channels (Austin, Tex.)

authors： Minor DL Jr,Findeisen F

更新日期：2010-11-01 00:00:00

abstract：:Based on stable integration of recombinant DNA into a host genome, transgenic technology has become an important genetic engineering methodology. An organism whose genetic characteristics have been altered by the insertion of foreign DNA is supposed to exhibit a new phenotype associated with the function of the transg...

journal_title：Channels (Austin, Tex.)

authors： Asemu G,Fishbein K,Lao QZ,Ravindran A,Herbert R,Canuto HC,Spencer RG,Soldatov NM

更新日期：2011-03-01 00:00:00

abstract：:It is well established that Pacemaker activity of the sino-atrial node (SAN) initiates the heartbeat. However, the atrioventricular node (AVN) can generate viable pacemaker activity in case of SAN failure, but we have limited knowledge of the ionic bases of AVN automaticity. We characterized pacemaker activity and ion...

journal_title：Channels (Austin, Tex.)

authors： Marger L,Mesirca P,Alig J,Torrente A,Dubel S,Engeland B,Kanani S,Fontanaud P,Striessnig J,Shin HS,Isbrandt D,Ehmke H,Nargeot J,Mangoni ME

更新日期：2011-05-01 00:00:00

abstract：:NHE3 is regulated via alterations in membrane surface charge. This is achieved through altered binding of cationic regions in the cytosolic-terminus of the exchanger with the inner leaflet of the plasma membrane. Calmodulin antagonists, including W-7, regulate surface potential and inhibit NHE3 activity. Utilizing flu...

journal_title：Channels (Austin, Tex.)

authors： Jaumouillé V,Krishnan D,Alexander RT

更新日期：2011-07-01 00:00:00

abstract：:The synaptic changes induced by initial drug exposure leave a trace on neural systems that can eventually manifest in compulsive drug-seeking behavior. A single injection of cocaine has been shown to induce a change in the AMPA receptor (AMPAR) subunit composition at glutamatergic synapses onto ventral tegmental area ...

journal_title：Channels (Austin, Tex.)

authors： Brown MT,Korn C,Lüscher C

更新日期：2011-11-01 00:00:00