Abstract:
:In this study, Borassus flabellifer (Linn.) (BF) immature endosperm was decellularized to produce three dimensional (3D) cellulose scaffolds that can support mammalian 3D cell culture. To this regard, we first evaluated the chemical composition, nutritive profile and pharmacological activities of BF endosperm. The results demonstrated that the BF tissue represented a complex concoction of polysaccharides with intrinsic phyto-ingredients which provide excellent pharmacological properties. Furthermore cellulosic scaffolds (CS) obtained from BF was treated with chitosan to produce cellulose-chitosan (CS/CHI) hybrid scaffolds. The comparative investigation on both scaffolds exhibited adequate swelling with controlled porosity and pore-size distribution. The physiochemical characterization showed reduced biodegradation, improved thermal stability and enhanced compressive strength in CS/CHI group. Biological studies reported favorable adhesion and proliferation of fibroblasts with evident cellular penetration and colonization on the both scaffolds. Taken together, plant derived cellulosic scaffolds could be used as an alternative scaffolding material in regenerative medicine.
journal_name
Carbohydr Polymjournal_title
Carbohydrate polymersauthors
Mahendiran B,Muthusamy S,Selvakumar R,Rajeswaran N,Sampath S,Jaisankar SN,Krishnakumar GSdoi
10.1016/j.carbpol.2021.118494keywords:
["3D scaffolds","Biocompatibility","Chitosan","Decellularization","Plant derived cellulose"]subject
Has Abstractpub_date
2021-11-15 00:00:00pages
118494eissn
0144-8617issn
1879-1344pii
S0144-8617(21)00881-Xjournal_volume
272pub_type
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