[8]-Gingerol exerts anti-myocardial ischemic effects in rats via modulation of the MAPK signaling pathway and L-type Ca2+ channels.

abstract：:Friedreich ataxia is an autosomal recessive, neurodegenerative disease characterized by the deficiency of the iron-sulfur cluster assembly protein frataxin. Loss of this protein impairs mitochondrial function. Mitochondria alter their morphology in response to various stresses; however, such alterations to morphology ...

journal_title：Pharmacology research & perspectives

authors： Johnson J,Mercado-Ayón E,Clark E,Lynch D,Lin H

更新日期：2021-05-01 00:00:00

abstract：:We conducted a systematic evaluation of lung inflammation indued by repeated intranasal exposure (for 10 consecutive days) to a human aeroallergen, house dust mite (HDM) in BALB/c mice. Peak influx of neutrophils, monocytes/lymphocytes, and eosinophils was observed in bronchoalveolar lavage (BAL) on days 1, 7 and 11, ...

journal_title：Pharmacology research & perspectives

authors： Malaviya R,Zhou Z,Raymond H,Wertheimer J,Jones B,Bunting R,Wilkinson P,Madireddy L,Hall L,Ryan M,Rao TS

更新日期：2021-05-01 00:00:00

abstract：:The aim was to analyze the relationship between peficitinib exposure and efficacy response according to American College of Rheumatology (ACR) 20 criteria and 28-joint disease activity score based on C-reactive protein (DAS28-CRP) in rheumatoid arthritis (RA) patients, and to identify relevant covariates by developing...

journal_title：Pharmacology research & perspectives

authors： Toyoshima J,Kaibara A,Shibata M,Kaneko Y,Izutsu H,Nishimura T

更新日期：2021-05-01 00:00:00

abstract：:Omecamtiv mecarbil (OM) is a novel medicine for systolic heart failure, targeting myosin to enhance cardiomyocyte performance. To assist translation to clinical practice we investigated OMs effect on explanted human failing hearts, specifically; contractile dynamics, interaction with the β1 -adrenoceptor (AR) agonist ...

journal_title：Pharmacology research & perspectives

authors： Dashwood A,Cheesman E,Wong YW,Haqqani H,Beard N,Hay K,Spratt M,Chan W,Molenaar P

更新日期：2021-05-01 00:00:00

abstract：:Lemborexant, a dual orexin receptor antagonist, is approved in the United States, Japan, and Canada for the treatment of insomnia in adults. This phase I, multicenter, open-label, parallel-group study assessed the impact of mild or moderate hepatic impairment (HI) on lemborexant pharmacokinetics and metabolism. The ph...

journal_title：Pharmacology research & perspectives

authors： Dayal S,Aluri J,Hall N,Filippov G,Moline M,Reyderman L,Landry I

更新日期：2021-04-01 00:00:00

abstract：:Cardiomyocyte apoptosis is a key factor in the deterioration of cardiac function after coronary microembolization (CME). Nicorandil (NIC) affects myocardial injury, which may be related to the inhibition of apoptosis. However, the specific mechanism of cardioprotection has not been elucidated. Therefore, we analyzed t...

journal_title：Pharmacology research & perspectives

authors： Zheng J,Long M,Qin Z,Wang F,Chen Z,Li L

更新日期：2021-02-01 00:00:00

abstract：:We report utilization patterns and characteristics of patients treated with biologic anti-inflammatory agents in a large commercially insured patient population in the United States. We identified adult (age ≥18 years) patients receiving biologic anti-inflammatory agents between 1 January 2012 and 31 March 2019 across...

journal_title：Pharmacology research & perspectives

authors： Mendelsohn AB,Nam YH,Marshall J,McDermott CL,Kochar B,Kappelman MD,Brown JS,Lockhart CM

更新日期：2021-02-01 00:00:00

abstract：:PC945 is a novel antifungal triazole formulated for nebulized delivery to treat lung Aspergillus infections. Pharmacokinetic and safety profiles from nonclinical studies and clinical trials in healthy subjects, and subjects with mild asthma were characterized. Toxicokinetics were assessed following daily 2-hour inhala...

journal_title：Pharmacology research & perspectives

authors： Cass L,Murray A,Davis A,Woodward K,Albayaty M,Ito K,Strong P,Ayrton J,Brindley C,Prosser J,Murray J,French E,Haywood P,Wallis C,Rapeport G

更新日期：2021-02-01 00:00:00

abstract：:Melanoma is responsible for most skin cancer deaths, and its incidence continues to rise year after year. Different treatment options have been developed for melanoma depending on the stage of the disease. Despite recent advances in immuno- and targeted therapies, advanced melanoma remains incurable and thus an urgent...

journal_title：Pharmacology research & perspectives

authors： Peng Y,Zhang Q,Zielinski RM,Howells RD,Welsh WJ

更新日期：2020-12-01 00:00:00

abstract：:The aim of this investigation was to characterize and compare the pharmacokinetics (PK) of the antimuscarinic drug solifenacin in pediatric patients with overactive bladder (OAB) or neurogenic detrusor overactivity (NDO) utilizing data from three phase III trials. LION was a placebo-controlled, 12-week trial in childr...

journal_title：Pharmacology research & perspectives

authors： Tannenbaum S,den Adel M,Krauwinkel W,Meijer J,Hollestein-Havelaar A,Verheggen F,Newgreen D

更新日期：2020-12-01 00:00:00

abstract：:Benzathine penicillin G (BPG) is used as first-line treatment for most forms of syphilis and as secondary prophylaxis against rheumatic heart disease (RHD). Perceptions that poor quality of BPG is linked to reported adverse effects and therapeutic failure may impact syphilis and RHD control programs. Clinical networks...

journal_title：Pharmacology research & perspectives

authors： Hand RM,Senarathna SMDKG,Page-Sharp M,Gray K,Sika-Paotonu D,Sheel M,Chuang VTG,Martinez J,Luna G,Manning L,Wyber R,Carapetis JR,Batty KT

更新日期：2020-12-01 00:00:00

abstract：:Cyclophosphamide (CP) is a chemotherapeutic agent which is extensively used in the treatment of multiple neoplastic and nonneoplastic diseases like breast cancer, lymphomas, systemic lupus erythematosus, and multiple sclerosis. Dose-limiting side effects, mainly nephrotoxicity is a major problem hindering its use in t...

journal_title：Pharmacology research & perspectives

authors： El-Shabrawy M,Mishriki A,Attia H,Emad Aboulhoda B,Emam M,Wanas H

更新日期：2020-10-01 00:00:00

abstract：:We have previously reported successful isolation and cryopreservation of human intestinal mucosa (CHIM) with retention of viability and drug metabolizing enzyme activities. Here we report the results of the quantification of drug metabolizing enzyme activities in CHIM from different regions of the small intestines fro...

journal_title：Pharmacology research & perspectives

authors： Li AP,Ho MD,Alam N,Mitchell W,Wong S,Yan Z,Kenny JR,E C A Hop C

更新日期：2020-10-01 00:00:00

abstract：:Social media is playing an increasingly central role in patient's decision-making process. Advances in technology have enabled meaningful interpretation of discussions on social media. We conducted a scoping review to assess whether Sentiment Analysis (SA), a big data analytic tool, could be used to extract meaningful...

journal_title：Pharmacology research & perspectives

authors： Sharma C,Whittle S,Haghighi PD,Burstein F,Keen H

更新日期：2020-10-01 00:00:00

abstract：:Apocynin has been widely used in vivo as a Nox2-contaninig nicotinamide adenine dinucleotide phosphate oxidase inhibitor. However, its time-dependent tissue distribution and inhibition on organ reactive oxygen species (ROS) production remained unclear. In this study, we examined apocynin pharmacokinetics and pharmacod...

journal_title：Pharmacology research & perspectives

authors： Liu F,Fan LM,Michael N,Li JM

更新日期：2020-08-01 00:00:00

abstract：:Severe hyperthermia from classical or exertional heatstroke, or from drug ingestion or other noninfective pyrogens, is associated with a high mortality and morbidity. A systemic pro-inflammatory response occurs during heatstroke, characterized by elevated cytokines with endotoxemia from elevated lipopolysaccharide (LP...

journal_title：Pharmacology research & perspectives

authors： Walter E,Gibson OR

更新日期：2020-08-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 novel coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific therapeutic approaches are available, hindering the fight against this disease and making better understanding of its pathogenesis essential. Despite similar...

journal_title：Pharmacology research & perspectives

authors： Braga CL,Silva-Aguiar RP,Battaglini D,Peruchetti DB,Robba C,Pelosi P,Rocco PRM,Caruso-Neves C,Silva PL

更新日期：2020-08-01 00:00:00

abstract：:To assess bioequivalence of a generic dabigatran etexilate capsule in healthy Chinese subjects under fasting and fed conditions. This was an open-label, single-center, randomized four-period crossover study with a 7-day washout period. A single oral dose of 150 mg generic dabigatran etexilate capsule (test drug) or a ...

journal_title：Pharmacology research & perspectives

authors： Li X,Liu L,Xu B,Xiang Q,Li Y,Zhang P,Wang Y,Xie Q,Mao Y,Cui Y

更新日期：2020-04-01 00:00:00

abstract：:The purpose of this study was to evaluate the quality of adverse drug reaction (ADR) documentation in a state-wide electronic health record (EHR), and to assess the impact of the interface design on documentation accuracy and ability to provide decision support. Data were extracted from 43 011 unique records in a stat...

journal_title：Pharmacology research & perspectives

authors： Foreman C,Smith WB,Caughey GE,Shakib S

更新日期：2020-04-01 00:00:00

abstract：:Human P-glycoprotein (P-gp) is a multispecific drug-efflux transporter, which plays an important role in drug resistance and drug disposition. Recent cryo-electron microscopy structures confirmed its rotationally symmetric architecture, which allows dual interaction with ATP and substrates. We here report the existenc...

journal_title：Pharmacology research & perspectives

authors： Nasim F,Schmid D,Szakács G,Sohail A,Sitte HH,Chiba P,Stockner T

更新日期：2020-04-01 00:00:00

abstract：:This study used retrospective chart review and survey data to evaluate: (1) off-label use of rituximab (MabThera®/Rituxan®) in autoimmune conditions and (2) patients' receipt and knowledge of the Patient Alert Card (PAC), a risk minimization measure for progressive multifocal leukoencephalopathy (PML) and serious infe...

journal_title：Pharmacology research & perspectives

authors： Sarsour K,Beckley-Kartey S,Melega S,Odueyungbo A,Kirchner P,Khalife N,Bangs J

更新日期：2020-01-03 00:00:00

abstract：:Monoclonal antibodies (mAbs) have emerged as a major class of therapeutic agents on the market. To date, approximately 80 mAbs have been granted marketing approval. In 2018, 12 new mAbs were approved by the FDA, representing 20% of the total number of approved drugs. The majority of mAb therapeutics are for oncologica...

journal_title：Pharmacology research & perspectives

authors： Castelli MS,McGonigle P,Hornby PJ

更新日期：2019-12-01 00:00:00

abstract：:Some immunomodulatory agents stimulate the release of cytokines capable of suppressing P450 enzymes and potentially affecting pharmacokinetics of coadministered medications. Cytokines released in response to an immunomodulator in the blood ex vivo can be used to screen for the potential for drug-drug interactions. Til...

journal_title：Pharmacology research & perspectives

authors： Czerwiński M,Gilligan K,Westland K,Ogilvie BW

更新日期：2019-12-10 00:00:00

abstract：:Aldehyde Oxidase (hAOX1) is a cytosolic enzyme involved in the metabolism of drugs and xenobiotic compounds. The enzyme belongs to the xanthine oxidase (XO) family of Mo containing enzyme and is a homo-dimer of two 150 kDa monomers. Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) of hAOX1 have been reported as ...

journal_title：Pharmacology research & perspectives

authors： Coelho C,Muthukumaran J,Santos-Silva T,João Romão M

更新日期：2019-11-22 00:00:00

abstract：:This study measured rates and trends in antibiotic dispensing for emergency department (ED) and outpatient visits by age groups. This retrospective analysis used data from the National Institutes of Health Collaboratory Distributed Research Network. The analysis included children (aged > 3 months to <12 years) and ado...

journal_title：Pharmacology research & perspectives

authors： Agiro A,Sridhar G,Gordon A,Brown J,Haynes K

更新日期：2019-08-27 00:00:00

abstract：:The novel clopidogrel conjugate, DT-678, is an effective inhibitor of platelets and thrombosis in preclinical studies. However, a comparison of the bleeding risk with DT-678 and currently approved P2Y12 antagonists has yet to be determined. The objective of this study was to evaluate the bleeding tendency of animals t...

journal_title：Pharmacology research & perspectives

authors： Lauver DA,Kuszynski DS,Christian BD,Bernard MP,Teuber JP,Markham BE,Chen YE,Zhang H

更新日期：2019-07-25 00:00:00

abstract：:Managing myocardial infarction (MI) to reduce cardiac cell death relies primarily on timely reperfusion of the affected coronary site, but reperfusion itself induces cell death through a toxic, ROS-mediated process. In this study, we determined whether the PrC-210 aminothiol ROS-scavenger could prevent ROS-induced dam...

journal_title：Pharmacology research & perspectives

authors： Hacker TA,Diarra G,Fahl BL,Back S,Kaufmann E,Fahl WE

更新日期：2019-07-12 00:00:00

abstract：:Acute pulmonary embolism may cause right heart failure due to increased pulmonary vascular resistance and arterial hypoxemia. Effective vasodilator therapy of the pulmonary hypertension is highly needed. Therefore, we investigated the effects of a newly developed effective pulmonary vasodilator, the organic mononitrit...

journal_title：Pharmacology research & perspectives

authors： Nilsson KF,Gustafsson LE

更新日期：2019-01-22 00:00:00

abstract：:The purpose of the study was to determine whether low-high fidelity medical simulation improves learning and long-lasting retention of pharmacology knowledge, compared to lecture alone, in undergraduate medical students. Ninety students, before a 45-minute lecture, were randomized into three groups - sham (S), low (LF...

journal_title：Pharmacology research & perspectives

authors： Arcoraci V,Squadrito F,Altavilla D,Bitto A,Minutoli L,Penna O,Amato A,Bruno R,Tripodi VF,Alibrandi A,Ingrassia PL,Santalucia P,Fodale V

更新日期：2019-01-09 00:00:00

abstract：:SMTP-7 (Stachybotrys microspora triprenyl phenol-7) is a small molecule that promotes thrombolysis and suppresses inflammation possibly through plasminogen modulation and soluble epoxide hydrolase (sEH) inhibition, respectively. Here, we demonstrate an efficacy of SMTP-7 in a severe embolic stroke model in monkeys. Th...

journal_title：Pharmacology research & perspectives

authors： Suzuki E,Nishimura N,Yoshikawa T,Kunikiyo Y,Hasegawa K,Hasumi K

更新日期：2018-12-05 00:00:00