Efficacy and safety of cladribine addition to induction treatment of newly diagnosed acute myeloid leukemia: a systematic review and meta-analysis.

abstract：:Telomeres consist of simple tandem hexametric (TTAGGG) repeats and progressively shorten with cell replication. To determine a relationship between telomeric erosion and response to treatment, we measured telomere length following treatment in patients with chronic myeloid leukemia (CML) in the chronic phase. We used ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Hayashi S,Iwama H,Yahata N,Ando K,Ohyashiki JH,Ohyashiki K

更新日期：1999-01-01 00:00:00

abstract：:Molecular techniques have a key role to play in laboratory and clinical haematology. Restriction enzymes allow nucleic acids to be reduced in size for subsequent analysis. In addition they allow selection of specific DNA or RNA sequences for cloning into bacterial plasmids. These plasmids are naturally occuring DNA mo...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Lawler M

更新日期：1999-01-01 00:00:00

abstract：:Low-Molecular-Weight Heparin (LMWH) fractions are prepared from standard unfractionated heparin (UFH) and are thus similar to it in many aspects. The major advantages of LMWH are improved efficacy and safety, longer half-life and reduced need for laboratory monitoring. In addition, the dangers of UFH administered by c...

journal_title：Hematology (Amsterdam, Netherlands)

authors： O'Shaughnessy DF

更新日期：2000-01-01 00:00:00

abstract：:Immunotherapy of malignant diseases remains a major therapeutic challenge. In multiple myeloma, interests have been focussed primarily on the targeting of the idiotypic protein since it represents one of the few tumor specific antigens. Various vaccination strategies have been employed, including the use of naked prot...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Lim SH,Wen YJ,Ling M

更新日期：2000-01-01 00:00:00

abstract：:Myeloma accounts for 1% of all malignancies and is characterised by the malignant expansion of plasma cells. It is essentially incurable with a median survival of 6 months untreated. Typically disseminated at presentation, myeloma requires systemic therapy, in those patients with advanced or progressive disease. Of si...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Smith ML,Kelsey SM

更新日期：2000-01-01 00:00:00

abstract：:The 80-100 fold increased immunohistological expression of the Gap Junction (GJ) protein Connexin-43 in murine bone marrow during the neonatal period and directly following cytoreductive treatment of adult mice suggests that the regulation of stem cell proliferation may involve GJ Intercellular Communication (GJIC). U...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Ploemacher RE,Mayen AE,De Koning AE,Krenacs T,Rosendaal M

更新日期：2000-01-01 00:00:00

abstract：:Previous studies have shown that the levels of hematopoietic progenitor cells (colony-forming cells; CFC) are drastically reduced in the vast majority of patients with aplastic anemia (AA). This has been observed both in patients before and after immunosuppressive therapy. In those studies, however, both groups of pat...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Martínez-Jaramillo G,Sánchez-Valle E,Gómez-Morales E,Montesinos JJ,Valencia I,Pizzuto-Chavez J,Mayani H

更新日期：2000-01-01 00:00:00

abstract：:The cadherins represent a large family of structurally and functionally related cell adhesion molecules involved in morphogenesis of multicellular organisms and maintenance of solid tissues. In the hematopoietic system, however, almost nothing was known about the involvement of this family. PCR screening of RNA of hum...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Armeanu S,MÜller CA,Klein G

更新日期：2000-01-01 00:00:00

abstract：:Little is known about the hematopoietic stem and progenitor cell membrane recognition and adhesion molecules which mediate their specific patterns of movement into and out of the marrow compartment during steady state hematopoiesis and during pathological conditions. Implicit in the cellular targeting of these cells t...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Hardy CL

更新日期：2001-01-01 00:00:00

abstract：:An 8-month-old girl had acute myelogenous leukemia (EAB M2) that relapsed 5 months after diagnosis during intensive consolidation chemotherapy. She underwent bone marrow transplantation (BMT) from an HLA-A, -B, -C and -DR phenotypically matched, but one locus DRB1 genotypically mismatched unrelated donor, but rejectio...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Shibuya A,Kaneko I,Ishii S,Sasaki N

更新日期：2002-04-01 00:00:00

abstract：:Apart from one report of phimosis, involvement of the penis has not been reported as a complication of chronic GVHD. We report a patient with recurrent chronic GVHD who developed skin discoloration of the penile shaft, together with erectile dysfunction consistent with Peyronie's disease. Histological features were co...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Grigg AP,Underhill C,Russell J,Sale G

更新日期：2002-06-01 00:00:00

abstract：:The therapeutic options for the indolent non-Hodgkin's lymphomas have evolved significantly over the years. However, at present, allogeneic haematopoietic stem cell transplantation (HSCT), despite its significant transplant associated complications, is still the only option which may be delivered with curative potenti...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Ho AY,Pagliuca A

更新日期：2002-12-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a hematological neoplasia that results from the transformation of a hematopoietic stem cell. It is characterized by the expansion of the myeloid lineage, which results in the accumulation of mature and immature granulocytes in peripheral blood and bone marrow. However, when CML marrow...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Luna-Bautista F,Sánchez-Valle E,Ayala-Sánchez M,Morales-Polanco M,Meillon-García L,Benítez-Bribiesca L,Mayani H

更新日期：2003-06-01 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells and are frequently used in current immunotherapy protocols. The administration of DCs loaded with tumor-associated proteins or peptides results in the induction of immune responses against different types of malignant cells. Methods for large-scale genera...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Büchler T,Michalek J,Kovarova L,Musilova R,Hajek R

更新日期：2003-04-01 00:00:00

abstract：:Syndecan-1 (CD138) mediates myeloma cell adhesion, and loss of syndecan-1 from the cell surface may contribute to myeloma cell proliferation and dissemination and influence the prognosis in patients with multiple myeloma (MM). In order to test this hypothesis, we have evaluated syndecan-1 expression on the surface of ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Aref S,Goda T,El-Sherbiny M

更新日期：2003-08-01 00:00:00

abstract：:The proteasome plays a key role in regulating protein degradation in eukaryotic cells. A range of synthetic inhibitors of proteasome activity have been developed which have helped elucidate its role in the cell. These inhibitors have selectively induced apoptosis in malignant cells in vitro suggesting that the proteas...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Magill L,Walker B,Irvine AE

更新日期：2003-10-01 00:00:00

abstract：:These studies were designed as two experiments. Experiment 1 was performed to validate the hypothesis that oxygen saturation of the venous blood may be a marker for vaso-occlusive crisis (VOC) in sickle cell patients undergoing hydroxyurea (HU) treatments. Experiment 2 was performed to test the hypothesis that an acut...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Nahavandi M,Tavakkoli F,Wyche MQ,Perlin E,Millis RM

更新日期：2003-12-01 00:00:00

abstract：:Haemoglobin E beta thalassemia (HbE beta thalassemia) has a remarkable variability in clinical expression ranging from a mild form of thalassemia intermedia to a transfusion dependent condition. An overlap between the mild variety of HbE beta thalassemia and homozygous HbE disease is common, however, differentiation i...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Tyagi S,Pati HP,Choudhry VP,Saxena R

更新日期：2004-02-01 00:00:00

abstract：:mu-heavy chain disease (HCD) is very rare, with only 30 cases reported in the literature. We report a patient with mu-HCD associated with systemic amyloidosis. The diagnosis of mu-HCD was based on findings of mu-heavy chain fragments in the serum, Bence Jones proteinuria and vacuolated plasma cells in the bone marrow....

journal_title：Hematology (Amsterdam, Netherlands)

authors： Kinoshita K,Yamagata T,Nozaki Y,Sugiyama M,Ikoma S,Funauchi M,Kanamaru A

更新日期：2004-04-01 00:00:00

abstract：:Therapy-related leukemia and therapy-related myelodysplasia (t-AML/MDS) are serious and increasingly frequent complications of cytotoxic chemotherapy and/or radiotherapy. Two syndromes can be distinguished, one of which has a long latency (5-7 years or more) and is seen following alkylating agents, frequently with an ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Rund D,Ben-Yehuda D

更新日期：2004-06-01 00:00:00

abstract：:Patients with sickle cell disease (SCD) have been shown to have impaired visual-motor speed and coordination. Sensorimotor deficits in mice can be investigated by motor coordination tests that require whole body movements such as the rotorod. A sickle transgenic mouse model (S+S-Antilles) that expresses human alpha, h...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Fasipe FR,Ubawike AE,Eva R,Fabry ME

更新日期：2004-08-01 00:00:00

abstract：:Second malignancies are frequent complications in patients with chronic lymphocytic leukemia (CLL). Patients with this leukemia may develop large cell lymphoma (LCL) known as Richter's syndrome (RS). RS occurs in CLL patients of about 3% and may develop in a single lymph node or more often in a group of nodes. However...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Robak T

更新日期：2004-10-01 00:00:00

abstract：:Cancer of the prostate can be associated with coagulopathy characterized as primary fibrinolysis or diffuse intravascular coagulopathy (DIC) with secondary fibrinolysis. These complications are usually associated with surgical manipulation of the prostate or with advanced metastatic disease. This report describes a pa...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Bern MM

更新日期：2005-02-01 00:00:00

abstract：:T-cell receptor Vss gene repertoire and clonality have been studied in patients with leukemia and solid tumors, by assaying the CDR3 size of TCR genes, using RT-PCR and genescan analysis. Few studies have studied leukemia-associated oligoclonal expanded T-cells in leukemia, therefore, the aim of this study was to inve...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Li Y,Chen S,Yang L,Zhou Y,Wu X,Huang M,Geng S

更新日期：2005-04-01 00:00:00

abstract：:The proven efficacy of ATO in the treatment of APL and the emerging importance of ATO in other diseases prompted extensive studies of the mechanisms of action of ATO in APL and in other types of cancers. In this review we will focus on downstream events in ATO-induced intrinsic and extrinsic apoptotic pathways with an...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Gazitt Y,Akay C

更新日期：2005-06-01 00:00:00

abstract：:The authors report the case of an 80-year-old male patient who presented with colitis and severe thrombocytopenia. The work-up revealed concurrent cytomegalovirus infection. After failure of prednisone, a single infusion of high-dose intravenous immunoglobulin produced a rapid and sustained response. Seventeen cases f...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Alliot C,Barrios M

更新日期：2005-08-01 00:00:00

abstract：:In 29 symptomatic children of both sexes with chronic idiopathic thrombocytopenic purpura (CITP) with platelet counts < or = 30,000/mm3, of mean age 7.2 +/- 1.3 years, the side effects of long-term glucocorticoid therapy were evaluated. Patients were divided into three groups based on the different glucocorticoid prot...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Ferrara M,Borrelli B,Greco N,Coppola L,Coppola A,Simeone G,Perrotta A,Capozzi L,Esposito L

更新日期：2005-10-01 00:00:00

abstract：INTRODUCTION:Risk factors for thrombosis (TB) in thrombocythaemia (TC) associated with myeloproliferative disorder (MPD) are not well defined. METHODS:We measured antiphospholipid antibodies (APLA) in 35 patients with TC associated with MPD. Fourteen had TB and 21 did not. We assayed IgG and IgM APLA by ELISA for 6 an...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Bidot CJ,Jy W,Horstman LL,Ahn ER,Bidot L,Fontana V,Ahn YS

更新日期：2005-12-01 00:00:00

abstract：:We present a case of a 64-year-old woman with neurofibromatosis (NF1) and smoldering multiple myeloma (SMM). SMM was diagnosed 9 years ago when the asymptomatic patient was found to have mild anemia, IgA paraproteinemia, hypogammaglobulinemia, osteopenia without any lytic bone lesions and bone marrow plasmacytosis. Du...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Danilatou V,Liapi D,Psyllaki M,Chatzivasili A,Chronaki I,Heliakis P

更新日期：2006-02-01 00:00:00

abstract：:The pathogenesis of thrombotic microangiopathy (TMA) after allogeneic bone marrow transplantation (BMT) remains unclear since ADAMTS13, which is implicated in primary thrombotic thrombocytopenic purpura (TTP), has been shown to have no role in this condition. We investigated whether the onset of TMA after BMT could be...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Takatsuka H,Nakajima T,Nomura K,Wakae T,Toda A,Itoi H,Okada M,Misawa M,Hara H

更新日期：2006-04-01 00:00:00