Extraction and measurement of urinary tetranor-PGDM in disposable diapers.

abstract：:The present study investigated the effects of cGMP on cytosolic Ca(2+) concentration ([Ca(2+)](c)) of isolated rat pancreatic beta-cells. In the presence of 7.0 mM glucose, NOC 7, a nitric oxide (NO) donor, caused an increase in [Ca(2+)](c) of the beta-cells, which was abolished by the soluble guanylate cyclase inhibi...

journal_title：Journal of pharmacological sciences

authors： Ishikawa T,Kaneko Y,Sugino F,Nakayama K

更新日期：2003-01-01 00:00:00

abstract：:Endothelial dysfunction is associated with pathological vascular conditions including atherosclerosis, hypertension, and diabetes. The oxidatively modified form of low-density lipoprotein (LDL) is recognized as a major cause of endothelial dysfunction in atherogenesis. As the receptor for oxidized LDL in endothelial c...

journal_title：Journal of pharmacological sciences

authors： Sakurai K,Sawamura T

更新日期：2003-03-01 00:00:00

abstract：:We examined the role of hydrogen peroxide production in cyclosporine A (CsA)-induced LLC-PK1 injury. After exposure to CsA (0.1 microM - 100 microM), cytotoxicity assessed by lactate dehydrogenase release to the media increased dose-dependently. LLC-PK1 cells produced hydrogen peroxide, visualized by 2,7-dichlorodihyd...

journal_title：Journal of pharmacological sciences

authors： Nishida M,Ogawa H,Tamai M,Ishiwari K,Hamaoka K

更新日期：2003-03-01 00:00:00

abstract：:Aqueous extracts of Ginseng radix have traditionally been used in the treatment of diabetes mellitus. In the present study, the effect of Ginseng radix on c-Fos expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via immunohistochemistry. Decreased c-Fos expression in the CA re...

journal_title：Journal of pharmacological sciences

authors： Jang MH,Chang HK,Shin MC,Lee TH,Kim YP,Kim EH,Kim CJ

更新日期：2003-02-01 00:00:00

abstract：:We investigated the effect of TTC-909, a drug preparation of the stable prostaglandin I(2) analogue clinprost (isocarbacyclin methylester; methyl 5-[(1S,5S,6R,7R)-7-hydroxy-6-[(E)-(S)-3-hydroxy-1-octenyl] bicyclo[3.3.0]oct-2-en-3-yl] pentanoate) incorporated into lipid microspheres, on cerebral infarction 7 days after...

journal_title：Journal of pharmacological sciences

authors： Karasawa Y,Komiyama H,Yoshida S,Hino N,Katsuura Y,Nakaike S,Araki H

更新日期：2003-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the accumulation of extracellular amyloid-beta (A beta) fibrils with microglia. Recently, there has been great interest in the microglial phagocytosis of A beta, because the microglial pathway is considered to be one of the A beta clearance pathways in the brain parenchyma....

journal_title：Journal of pharmacological sciences

authors： Kitamura Y,Shibagaki K,Takata K,Tsuchiya D,Taniguchi T,Gebicke-Haerter PJ,Miki H,Takenawa T,Shimohama S

更新日期：2003-06-01 00:00:00

abstract：:Histamine, prostaglandin E(2), and catecholamines have been demonstrated to regulate the innate and acquired immune responses. In this review, we describe one of the mechanisms common to the action of these agonists; the regulation of the expression of costimulatory adhesion molecules such as ICAM-1 and B7 antigens on...

journal_title：Journal of pharmacological sciences

authors： Nishibori M,Takahashi HK,Mori S

更新日期：2003-05-01 00:00:00

abstract：:The response latencies of the biting response in the tail-pinch test and step-through response in the passive avoidance test were measured in mice. 1) Scopolamine decreased the latency of the step-through response in the passive avoidance test, but diazepam did not. 2) Morphine (5 mg/kg, i.p.) was given 30 min before ...

journal_title：Journal of pharmacological sciences

authors： Nakama-Kitamura M,Doe N

更新日期：2003-07-01 00:00:00

abstract：:We previously reported that in the endothelium-denuded rat aorta, lysophosphatidylcholine (LPC) potentiates the contractile responses induced by high-K(+), UK14,304 (a selective alpha(2)-adrenoceptor agonist), and phorbol ester with an associated tyrosine-phosphorylation of proteins. To further investigate this phenom...

journal_title：Journal of pharmacological sciences

authors： Suenaga H,Kamata K

更新日期：2003-08-01 00:00:00

abstract：:We compared the degree of neurotoxic outcome in the retina exposed to three nitric oxide (NO) donors with different half-life of NO release. Intravitreal injection of NO donors resulted in a significant decrease in cell density in the ganglion cell layer and thinning of the inner plexiform layer in a half-life time-de...

journal_title：Journal of pharmacological sciences

authors： Takahata K,Katsuki H,Kume T,Ito K,Tochikawa Y,Muraoka S,Yoneda F,Kashii S,Honda Y,Akaike A

更新日期：2003-08-01 00:00:00

abstract：:Myristoylated alanine-rich C-kinase substrate (MARCKS) is an actin-binding protein whose function may be regulated by the phosphorylation of multiple sites, in which the phosphorylation site domain (PSD) is recognized to have three or four PKC-dependent sites. Recently, it is considered that MARCKS is implicated in so...

journal_title：Journal of pharmacological sciences

authors： Sasaki Y

更新日期：2003-09-01 00:00:00

abstract：:The blockade of myocardial K(ATP) channels may be antiarrhythmic for ischemic arrhythmias. A new sulfonylthiourea, HMR1098 (1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenylsulfonyl]-3-methylthiourea, sodium salt), was demonstrated to be a cardioselective K(ATP)-channel antagonist and to suppress arrhythmias during...

journal_title：Journal of pharmacological sciences

authors： Zhu BM,Miyamoto S,Nagasawa Y,Wajima T,Hashimoto K

更新日期：2003-09-01 00:00:00

abstract：:Alzheimer's disease is a progressive neurodegenerative disorder characterized by a gradual decline in memory. The occurrence of Alzheimer's disease is commonplace among the Asian population, particularly among senior citizens. The present study was undertaken to assess the potential of ascorbic acid as a memory-enhanc...

journal_title：Journal of pharmacological sciences

authors： Parle M,Dhingra D

更新日期：2003-10-01 00:00:00

abstract：:Melatonin, a major hormone secreted by the pineal gland, is known to play an important role in regulation of the circadian rhythm. (N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon) is a non-benzodiazepine hypnotic that acts via the benzodiazepine site of the GABA(A) receptor. In the prese...

journal_title：Journal of pharmacological sciences

authors： Noguchi H,Kitazumi K,Mori M,Shiobara Y,Shiba T

更新日期：2003-10-01 00:00:00

abstract：:Recent developments in optoelectronics permit real-time Ca(2+) imaging of thin planes within cells utilizing laser scanning confocal microscopy (LSCM). However, a major complication associated with this imaging system involves increased phototoxicity with improved spatiotemporal resolution. Two-photon excitation micro...

journal_title：Journal of pharmacological sciences

authors： Ohata H,Yamada H,Niioka T,Yamamoto M,Momose K

更新日期：2003-11-01 00:00:00

abstract：:The inhibitory effect of an anti-ulcer drug irsogladine [2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate] on monochloramine (NH(2)Cl)-induced gastric mucosal lesions and its mechanisms of action were clarified in rats. Irsogladine dose-dependently prevented the formation of gastric mucosal lesions induced by 60 ...

journal_title：Journal of pharmacological sciences

authors： Kyoi T,Oka M,Noda K,Ukai Y

更新日期：2003-11-01 00:00:00

abstract：:Evidence has accumulated that impairment of vascular endothelial function is the initial step in the development of atherosclerosis. One important finding is impairment of the release of endothelium-dependent relaxing factor, which is now thought to be nitric oxide or its related substances, from endothelial cells. Fl...

journal_title：Journal of pharmacological sciences

authors： Hashimoto M,Miyamoto Y,Matsuda Y,Akita H

更新日期：2003-12-01 00:00:00

abstract：:Interleukin (IL)-6 has been shown to protect neuronal cells from cell death induced by various stimulants. Although neuronal cells including PC12 cells were shown to produce IL-6, little is known about the effects of dopaminergic neurotoxins, 1,2,3,4-tetrahydroisoquinoline (TIQ) and 1-methyl-4-phenylpyridinium ion (MP...

journal_title：Journal of pharmacological sciences

authors： Shimma N,Akiyama N,Umezawa M,Okuma Y,Nomura Y,Saito T,Horie S,Murayama T

更新日期：2003-12-01 00:00:00

abstract：:Effects of ethanol extracts of three Chinese medicinal plants, namely, Qinpi (Fraxini cortex), Kushen (Sophora flavescens, AITON), and Huanglian (Coptis teeta, WALLICH), on ion transport of the rat intestinal epithelia were determined in this study. Rat intestinal epithelia mounted in an Ussing chamber attached to a v...

journal_title：Journal of pharmacological sciences

authors： Tsai JC,Tsai S,Chang WC

更新日期：2004-01-01 00:00:00

abstract：:Oxybutynin has been used for neurogenic bladder disorders and is known to have anti-cholinergic and antispasmodic properties. However, the anti-cholinergic and antispasmodic properties of 4-ethylamino-2-butynyl(2-cyclohexyl-2-phenyl)glycolate hydrochloride (N-desethyloxybutynin: DEOB), a metabolite of oxybutynin, have...

journal_title：Journal of pharmacological sciences

authors： Uchida M,Koganei M,Murata N,Yamaji T

更新日期：2004-02-01 00:00:00

abstract：:We have elucidated the interactions of human and rat organic anion transporters (hOATs and rOATs) with pravastatin and cimetidine. Pravastatin inhibited hOAT1/rOAT1, hOAT2/rOAT2, hOAT3/rOAT3, and hOAT4. The mode of inhibition was noncompetitive for hOAT1 and hOAT2, whereas it was competitive for hOAT3 and hOAT4. Cimet...

journal_title：Journal of pharmacological sciences

authors： Khamdang S,Takeda M,Shimoda M,Noshiro R,Narikawa S,Huang XL,Enomoto A,Piyachaturawat P,Endou H

更新日期：2004-02-01 00:00:00

abstract：:The encephalographic (EEG) properties of zaleplon were investigated in comparison with those of other sedative hypnotics in conscious rats with chronically implanted electrodes. The oral administration of zaleplon (0.25-1.0 mg/kg), triazolam (0.0625-0.25 mg/kg), zopiclone (1.0-4.0 mg/kg), brotizolam (0.0625-0.25 mg/kg...

journal_title：Journal of pharmacological sciences

authors： Noguchi H,Kitazumi K,Mori M,Shiba T

更新日期：2004-03-01 00:00:00

abstract：:Antigen-induced aggregation of the high affinity IgE receptor (FcepsilonRI) on mast cells induces degranulation to release chemical mediators, leading to acute allergic inflammation. We have demonstrated that the treatment of rat mast cells, RBL-2H3, with a phenoxazine derivative Phx-1 (2-amino-4,4alpha-dihydro-4alpha...

journal_title：Journal of pharmacological sciences

authors： Enoki E,Sada K,Qu X,Kyo S,Miah SM,Hatani T,Tomoda A,Yamamura H

更新日期：2004-03-01 00:00:00

abstract：:In the present experiment, we studied the action of buckwheat polyphenol (BWP, from Fagopyrum esculentum MOENCH) in a repeated cerebral ischemia model, which induced a strong and long-lasting impairment of spatial memory in 8-arm radial maze with hippocampal CA1 cell death in rats. BWP (600 mg/kg, continuous 21-day p....

journal_title：Journal of pharmacological sciences

authors： Pu F,Mishima K,Egashira N,Iwasaki K,Kaneko T,Uchida T,Irie K,Ishibashi D,Fujii H,Kosuna K,Fujiwara M

更新日期：2004-04-01 00:00:00

abstract：:Acute effect of Mao-Bushi-Saishin-To (Ma-Huang-Fu-Zi-Xi-Xin-Tang in Chinese: MBS) on histamine release was investigated. The IgE-mediated anaphylaxic response in Wistar rats was significantly suppressed by MBS and Mao. However, Saishin and Bushi had no or little effect on the antigen-mediated anaphylaxic reaction. Mao...

journal_title：Journal of pharmacological sciences

authors： Saito SY,Maruyama Y,Kamiyama S,Nakahata N,Ohizumi Y

更新日期：2004-05-01 00:00:00

abstract：:Adenosine enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. We found that adenosine increases NGF-induced phosphorylation of extracellular signal-regulated kinase (ERK), but decreases the duration of phosphorylation of p38 mitogen-activated protein (MAP) kinase. Therefore, we further examined...

journal_title：Journal of pharmacological sciences

authors： Muroi Y,Ishii T,Teramoto K,Hori M,Nishimura M

更新日期：2004-05-01 00:00:00

abstract：:We are exposed to many external and internal stresses in this day and age. Stress weakens the function of immune systems in living organisms and disturbs homeostasis. As a result, stress induces various psychosomatic diseases. Thus, ways of reducing stress and thus protecting humans from disease must be developed. One...

journal_title：Journal of pharmacological sciences

authors： Kaneko H,Nakanishi K

更新日期：2004-06-01 00:00:00

abstract：:We examined if a range of carbonic anhydrase inhibitors (CAIs) interacted with the high-voltage activated voltage-sensitive calcium channels (VSCCs) encoded by the human alpha(1E) subunit. Whole-cell recordings were made from HEK293 cells stably expressing human alpha(1E)beta(3)-mediated calcium channels. SNX-482 (an ...

journal_title：Journal of pharmacological sciences

authors： McNaughton NC,Davies CH,Randall A

更新日期：2004-06-01 00:00:00

abstract：:The present study is part of a project on phospholipase D (PLD) in cardiac hypertrophy and analyzed effects on PLD activity of two growth stimuli, norepinephrine (NE) and cardiotrophin-1 (CT-1), in incubated rat heart. Phosphatidylcholine (PC) was labeled by (3)H-myristic acid. PLD produced (3)H-phosphatidylethanol ((...

journal_title：Journal of pharmacological sciences

authors： Weismüller T,Klein J,Löffelholz K

更新日期：2004-07-01 00:00:00

abstract：:Platelet-activating factor (PAF) plays important roles in allergic reactions. In particular, there are many concerns about PAF, eosinophils, and the chronicity of allergic diseases. The purpose of the present studies is to elucidate the role of PAF in eosinophil activation at conjunctiva and to confirm the efficacy of...

journal_title：Journal of pharmacological sciences

authors： Kato M,Imoto K,Miyake H,Oda T,Miyaji S,Nakamura M

更新日期：2004-08-01 00:00:00