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Cardiac magnetic resonance in recovering COVID-19 patients. Feature tracking and mapping analysis to detect persistent myocardial involvement.

Abstract：

Background:Post-COVID-19 patients may incur myocardial involvement secondary to systemic inflammation. Our aim was to detect possible oedema/diffuse fibrosis using cardiac magnetic resonance imaging (CMR) mapping and to study myocardial deformation of the left ventricle (LV) using feature tracking (FT). Methods:Prospective analysis of consecutively recruited post-COVID-19 patients undergoing CMR. T1 and T2 mapping sequences were acquired and FT analysis was performed using 2D steady-state free precession cine sequences. Statistical significance was set to p < 0.05. Results:Included were 57 post-COVID-19 patients and 20 healthy controls, mean age 59 ± 15 years, men 80.7%. The most frequent risk factors were hypertension (33.3%) and dyslipidaemia (36.8%). The contact-to-CMR interval was 81 ± 27 days. LV ejection fraction (LVEF) was 61 ± 10%. Late gadolinium enhancement (LGE) was evident in 26.3% of patients (19.3%, non-ischaemic). T2 mapping values (suggestive of oedema) were higher in the study patients than in the controls (50.9 ± 4.3 ms vs 48 ± 1.9 ms, p < 0.01). No between-group differences were observed for native T1 nor for circumferential strain (CS) or radial strain (RS) values (18.6 ± 3.3% vs 19.2 ± 2.1% (p = 0.52) and 32.3 ± 8.1% vs 33.6 ± 7.1% (p = 0.9), respectively). A sub-group analysis for the contact-to-CMR interval (<8 weeks vs ≥ 8 weeks) showed that FT-CS (15.6 ± 2.2% vs 18.9 ± 2.6%, p < 0.01) and FT-RS (24.9 ± 5.8 vs 33.5 ± 7.2%, p < 0.01) values were lower for the shorter interval. Conclusions:Post-COVID-19 patients compared to heathy controls had raised T2 values (related to oedema), but similar native T1, FT-CS and FT-RS values. FT-CS and FT-RS values were lower in post-COVID-19 patients undergoing CMR after < 8 weeks compared to ≥ 8 weeks.

journal_name

Int J Cardiol Heart Vasc

journal_title

International journal of cardiology. Heart & vasculature

authors

Urmeneta Ulloa J,Martínez de Vega V,Salvador Montañés O,Álvarez Vázquez A,Sánchez-Enrique C,Hernández Jiménez S,Sancho García FD,López Ruiz L,Recio Rodríguez M,Pizarro G,Carnevali Ruiz D,Ángel Cabrera J

doi

10.1016/j.ijcha.2021.100854

keywords:

["CMR, Cardiac-magnetic-resonance-imaging","COVID-19","COVID-19, coronavirus disease-2019","CRP, C-reactive-protein","CS, circumferential-strain","Cardiac magnetic resonance imaging","ECG, electrocardiogram","ECV, extracellular-volume","EGE, early-gadolinium-enhancement","FT, feature-tracking","Feature tracking","ICU, intensive-care-unit","IQR, interquartile-range","IR, inversion-recovery","LAX, long-axis-view","LGE, late-gadolinium-enhancement","LS, longitudinal-strain","LV, left-ventricle","LVEDV, LV end-diastolic-volume","LVEF, LV-Ejection-fraction","LVESV, LV-end-systolic-volume","MERS-CoV, Middle-East-respiratory-syndrome-coronavirus","Mapping","PCR, polymerase-chain-reaction","ROI, region-of-interest","RS, radial-strain","RV, right-ventricle","RVEDV, end-diastolic-volume","RVEF, RV-ejection-fraction","RVESV, RV-end-systolic-volume","SARS-CoV-2, severe-acute-respiratory-syndrome-coronavirus-2","SAX, short-axis-view","SCLS, systemic-capillary-leak-syndrome","SD, standard-deviation","SIRS, systemic-inflammatory-response-syndrome","SSFP, steady-state-free-precession","STIR, short-tau-inversion-recovery","TR, repetition-time","TTE, transthoracic-echocardiography"]

subject

Has Abstract

pub_date

2021-10-01 00:00:00

pages

100854

issn

2352-9067

pii

S2352-9067(21)00142-1

journal_volume

pub_type

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Cardiac magnetic resonance in recovering COVID-19 patients. Feature tracking and mapping analysis to detect persistent myocardial involvement.