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The efficiency of prostate-specific antigen density measurement using three different methods on the prediction of biochemical recurrence.

Abstract：

BACKGROUND:The aim of this study was to evaluate the efficiency of prostate-specific antigen (PSA) density (PSAD) calculated through prostate volume (PV) obtained via transrectal ultrasound (TRUS) and magnetic resonance imaging (MRI) and actual prostate weight (PW) methods obtained via pathological evaluation on the prediction of biochemical recurrence (BCR) in the follow-ups of patients who had undergone radical prostatectomy (RP). METHODS:A total of 335 clinically localized prostate cancer (PCa) patients who had received open RP between January 2015 and December 2018 were enrolled in the study. Pre and postoperative demographic data, clinical and pathological findings and BCR conditions were recorded. The PSAD was calculated using information obtained through preoperative TRUS examinations, MRI, and collected pathological specimens after RP by dividing the maximum preoperative PSA value and PV/PW. RESULTS:In a mean follow-up duration of 20.2 ± 8.5 months, recurrence was observed in 52 patients (24.4%) and progression was observed in 8 (3.8%) patients. The TRUS-PSAD, MRI-PSAD, and PW-PSAD values were statistically significantly higher in BCR patients compared to non-BCR patients. The International Society of Urologic Pathologists (ISUP) grade 5 and pT3b as a pathological stage were detected as independent variables in the prediction of BCR formation. Actual PW had a high prediction value compared to other PSAD measurements at <40 g prostate weights, but it had a low prediction value in prostates with an actual PW >60 g. CONCLUSIONS:In this study, it was stated that PSAD acquired through different imaging methods does not affect the usability of PSAD in BCR prediction in clinical practice. The ISUP grade 5 and pT3b stage PCa were detected as independent markers in BCR prediction after RP.

journal_name

Aging Male

journal_title

The aging male : the official journal of the International Society for the Study of the Aging Male

authors

Danacioglu YO,Keser F,Efiloğlu Ö,Culpan M,Polat S,Atis RG,Yildirim A

doi

10.1080/13685538.2021.1924667

keywords:

["Prostate specific antigen density","biochemical recurrence","prostate cancer","prostate volume","radical prostatectomy"]

subject

Has Abstract

pub_date

2021-12-01 00:00:00

pages

15-23

issue

eissn

1368-5538

issn

1473-0790

journal_volume

pub_type

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The efficiency of prostate-specific antigen density measurement using three different methods on the prediction of biochemical recurrence.