Abstract:
PURPOSE:To identify the clinical characteristics, histopathological features, and prognosis of kidney disease in a large cohort of elderly patients from Northeast China. METHODS:We retrospectively analyzed the renal disease spectrum in 7,122 patients who underwent renal biopsies at the Second Hospital of Jilin University from 2006 to 2020. Patients were grouped according to age: below 60 years (non-elderly group, n = 5923) and at least 60 years (elderly group, n = 1199). The clinical and pathological characteristics of renal biopsy patients in the groups were analyzed using the t-test and chi-square test. RESULTS:Compared with the non-elderly group, the elderly group had significantly fewer patients with primary glomerulonephritis, but more patients with tubulointerstitial disorders (p < .05). The incidence of IgA nephropathy, mesangial proliferative glomerulonephritis, and lupus nephritis was significantly lower in elderly patients than in non-elderly patients. The incidence of membranous nephropathy, membranoproliferative glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, systemic vasculitis-associated renal damage, and amyloid nephropathy was significantly higher in elderly patients than in non-elderly patients (p < .05). The incidence of perinephric hematoma (≥4 cm2) in elderly patients with renal biopsy was lower than that in non-elderly patients. We noted that 79.9% of primary glomerulonephritis patients who received immunosuppressive therapy showed a remission rate of 83.5%. CONCLUSION:The spectrum of kidney disease in the elderly is different from that in the younger population.
journal_name
Ren Failjournal_title
Renal failureauthors
Nie P,Lou Y,Wang Y,Bai X,Zhang L,Jiang S,Li B,Luo Pdoi
10.1080/0886022X.2021.1923527keywords:
["elderly","pathology","primary glomerulonephritis","prognosis","renal biopsy"]subject
Has Abstractpub_date
2021-12-01 00:00:00pages
851-859issue
1eissn
0886-022Xissn
1525-6049journal_volume
43pub_type
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