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Prospective, randomized, double-blind study of prophylactic antibiotics in axillary lymph node dissection.

Abstract：

BACKGROUND:Antibiotic prophylaxis is controversial in patients undergoing axillary lymph node dissection (ALND). We determined whether preoperative antibiotics decreased incidence or treatment cost of infectious complications following ALND. METHODS:Two hundred patients entered this prospective, randomized, double-blind trial. Patients received either placebo or cefonicid preoperatively. Loco-regional signs of infection were monitored for 4 weeks postoperatively. RESULTS:There was a trend toward fewer infections in the prophylactic group (placebo 13% versus cefonicid 6%; P = 0.080). Cefonicid significantly decreased severe infections requiring hospitalization (placebo 8% versus cefonicid 1%; P = 0.033). Cefonicid also decreased the treatment cost of infection per patient ($49.80 versus $364.87). CONCLUSIONS:We demonstrated a trend toward fewer overall infections and significantly fewer severe infections in patients given prophylactic antibiotics, which translated into a decrease in the cost of treatment for infectious complications. These findings support antibiotic prophylaxis for patients undergoing ALND.

journal_name

Am J Surg

journal_title

American journal of surgery

authors

Bold RJ,Mansfield PF,Berger DH,Pollock RE,Singletary SE,Ames FC,Balch CM,Hohn DC,Ross MI

doi

10.1016/s0002-9610(98)00154-8

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

239-43

issue

3

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(98)00154-8

journal_volume

176

pub_type

临床试验,杂志文章,随机对照试验

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