Abstract:
:Myelomeningocele (MMC) is characterized by paraplegia and incontinence, often necessitating surgery. Current models of MMC in sheep and primates create a spinal defect long after anomalous neural tube closure ordinarily occurs. An ideal model of MMC would allow creation of the defect at the earliest age in a low-cost species with a short gestation. We present a method utilizing the holmium laser to create spinal defects in rabbits in utero for the study of the pathophysiology and repair of MMC. Pregnant rabbits of 22 to 23 days' gestational age were prepared and draped in sterile fashion for laparotomy under general anesthesia. The abdomen was opened, and both uterine horns were inspected. Double opposing pursestring sutures were placed to secure the chorioamniotic membranes over the fetal lumbar spine. Amniotic fluid was removed with a needle and saved. Electrocautery was used to open the uterus within the pursestring suture, exposing the fetal dorsum. The spine was exposed by laser dissection of the fetal dorsal musculature. Posterior laminectomy was accomplished with laser incisions of each side of the spinous process, leaving the underlying dura and cord exposed. The pursestring was then cinched, amniotic fluid was returned, and the uterus and trocar sites were closed. Cesarian section was performed at 30 to 31 gestational days, and the pups were examined and then humanely sacrificed for histologic evaluation of the lesion. The rabbit is an inexpensive species with a short gestation (33-35 days), and four or more fetuses may be operated on per litter, with the remainder serving as controls. Utilization of minimally invasive techniques including holmium:YAG laser dissection facilitates creation of spinal defects at an early age in this small-animal model.
journal_name
J Endouroljournal_title
Journal of endourologyauthors
Calvano CJ,Reddy PP,Moran ME,Boyle KE,Housley HT,Jennings RW,Harrison MR,Mandell Jdoi
10.1089/end.1998.12.199subject
Has Abstractpub_date
1998-04-01 00:00:00pages
199-203issue
2eissn
0892-7790issn
1557-900Xjournal_volume
12pub_type
杂志文章abstract::Extravesical robotic-assisted laparoscopic ureteral reimplantation in children is a challenging procedure. Our top-down suturing technique facilitates this reconstructive surgery. After mobilization of the ureter without the use of ureteral stent placement, the detrusor muscle is divided. Once adequate muscle flaps ar...
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pub_type: 杂志文章
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journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:Journal of endourology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:10.1089/end.2006.20.202
更新日期:2006-03-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2012.0344
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pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章,meta分析,评审
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更新日期:2011-11-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2007-10-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章,多中心研究
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journal_title:Journal of endourology
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pub_type: 杂志文章
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journal_title:Journal of endourology
pub_type: 杂志文章,评审
doi:10.1089/end.2009.1518
更新日期:2009-10-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:1994-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2002-02-01 00:00:00
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pub_type: 杂志文章
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