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11q13 allelotype analysis in 27 northern American MEN1 kindreds identifies two distinct founder chromosomes.

Abstract：

:We analyzed constitutional and tumor DNA from 27 MEN1 kindreds not known to be related to each other. Disease allele haplotypes were constructed for each pedigree based on shared alleles from two or more affected members and from determination of allelic loss patterns in their tumors. Analysis of disease allele haplotypes showed unexpected linkage disequilibrium at marker PYGM. Further haplotype analysis indicated this could be explained by the presence of two founder chromosomes, one in four families, the other in three. A shared disease haplotype was not observed among two MEN1 kindreds with the prolactinoma phenotype of MEN1.

journal_name

Mol Genet Metab

journal_title

Molecular genetics and metabolism

authors

Emmert-Buck MR,Debelenko LV,Agarwal S,Kester MB,Manickam P,Zhuang Z,Guru SC,Olufemi SE,Burns AL,Chandrasekharappa SC,Lubensky IA,Liotta LA,Skarulis MC,Spiegel AM,Marx SJ,Collins FS

doi

10.1006/mgme.1997.2649

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

151-5

issue

2

eissn

1096-7192

issn

1096-7206

pii

S1096-7192(97)92649-4

journal_volume

63

pub_type

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