Abstract：
:This study was undertaken to evaluate the feasibility of performing vascularized musculoskeletal xenografts between mice and rats using immunosuppression. Vascularized musculoskeletal grafts were harvested from the hind limb of C57BL/6J (B6) mice, transplanted heterotopically into Lewis rats, and revascularized by microanastomoses of the graft artery and the recipient femoral artery and the graft vein to the recipient femoral vein. Recipient rats were divided into four groups. Group 1 received no immunosuppression (n = 10), group 2 was treated with cyclosporine (10 mg/kg/day; n = 10), group 3 was treated with 15-deoxyspergualin (5 mg/kg/day; n = 10), and group 4 received both cyclosporine and 15-deoxyspergualin (n = 10). Graft survival was directly examined on postoperative days 4, 7, and 14. In vitro assays were performed using mixed lymphocyte reactions and anti-donor cytotoxic antibody assays to assess the recipient's immune response. Grafts were examined by histology and immunohistochemistry. All grafts in group 1 were rejected by day 4. In groups 2 and 3, all grafts were rejected by day 7. In group 4, however, 8 of 10 recipients had viable grafts on day 14. Data from mixed lymphocyte reactions showed that cell-mediated immune responses were uniformly suppressed in groups 2, 3, and 4 compared with group 1. However, anti-donor antibody production was only partly suppressed in groups 2 and 3, suggesting that graft rejection was primarily caused by circulating cytotoxic anti-donor antibodies in groups 1, 2, and 3. Histologic observations in groups 1, 2, and 3 confirmed the important role of the humoral mechanism in xenograft rejection. Furthermore, immunohistochemical results demonstrated that the small vessels in the rejected grafts showed anti-rat immunoglobulin and complement depositions. Only a combination therapy of cyclosporine and 15-deoxyspergualin attenuated the rejection of xenografts.
journal_name
Plast Reconstr Surgjournal_title
Plastic and reconstructive surgeryauthors
Tanabe YN,Randolph MA,Shimizu A,Butler PE,Lee WPdoi
10.1097/00006534-200004050-00015subject
Has Abstractpub_date
2000-04-01 00:00:00pages
1695-703issue
5eissn
0032-1052issn
1529-4242journal_volume
105pub_type
杂志文章abstract：:We have used this technique in two patients. One had early sternal dehiscence with presternal infection, and the other had late sternal nonunion. Uncomplicated sternal union was achieved in both patients. The cables were nonpalpable in both patients, but they were removed in one patient at that patient's request. This...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/00006534-200010000-00019
更新日期：2000-10-01 00:00:00
abstract：:For breast reconstruction, we have found that breast symmetry can be created optimally when the patient is brought to a totally upright position with the trunk vertical and perpendicular to the floor. The size of the opposite breast can better be appreciated. Nipple and areola position can be determined accurately eve...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/00006534-198601000-00010
更新日期：1986-01-01 00:00:00
abstract：:An inflatable breast implant having a detachable filling reservoir is described. Once in position, the implant can be filled under controlled conditions postoperatively. The implant functions either as a tissue expander or as a delayed-filling implant in the initial stages of the procedure. Once the desired breast siz...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/00006534-198404000-00031
更新日期：1984-04-01 00:00:00
abstract：BACKGROUND:The dorsal metacarpal artery perforator flap is a versatile solution for resurfacing soft-tissue defects of fingers. The authors present their experience in applying this flap for a variety of finger wounds for which conventional means may not be amenable. METHODS:Fifty-eight dorsal metacarpal artery perfor...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/PRS.0b013e318221ddfa
更新日期：2011-09-01 00:00:00
abstract：:Breast cancer is the tumor with the highest prevalence and incidence in women. Reduction mammaplasty is one of the most common procedures performed in Brazil by the plastic surgeon, and it is not uncommon for the surgeon to find a breast tumor during the operation or afterward, when the histopathological report is rec...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/01.prs.0000152683.62899.50
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND:Most managed care plans use a physician "gatekeeper" to control referrals to hand surgeons. The appropriateness of this model for upper extremity complaints has never been challenged. The purpose of this study was to evaluate the prior management of patients with elective hand disorders who present to a hand...
journal_title：Plastic and reconstructive surgery
pub_type： 临床试验,杂志文章
doi：10.1097/PRS.0b013e31829acc74
更新日期：2013-09-01 00:00:00
abstract：:Treatment options for the craniosynostoses vary from conservative observation until completion of growth to radical remodeling in infancy. To further define the timing and type of treatment necessary in these complex disorders, we have retrospectively analyzed all patients operated on for this deformity during the pas...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：BACKGROUND:The psychosocial benefits of postmastectomy breast reconstruction are well established; however, health care barriers persist. The authors evaluated statewide patient population to further identify obstacles to reconstruction. METHODS:A linked data set combining the North Carolina Central Cancer Registry wi...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/PRS.0000000000002343
更新日期：2016-08-01 00:00:00
abstract：:Controversy exists in the literature regarding reconstruction of the radial artery after elevation of the radial forearm flap. The literature suggests that reconstructing the radial artery with a vein graft is an important aspect in the use of this flap. In our experience, this has never been performed with no sequela...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：BACKGROUND:The serratus anterior flap is commonly used without its cutaneous component and is covered with a skin graft. The authors have successfully used the free serratus anterior flap along with its skin paddle and have found it to be valuable for reconstruction of the face. METHODS:Fresh cadaveric dissections and...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/01.prs.0000208297.02556.a5
更新日期：2006-04-01 00:00:00
abstract：:An 18-year-old girl had a cyst excised from the left buttock in 1988. The cyst was diagnosed to be a cutaneous ciliated cyst, since histologic examination using special stains demonstrated its lining to be similar to fallopian tube epithelium. Only 20 such cases have been published to date, and this report is probably...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章,评审
doi：
更新日期：1990-08-01 00:00:00
abstract：:According to recent data, augmentation gluteoplasty continues to gain popularity in the United States and globally, especially in procedures involving fat grafts. However, serious concerns about its safety have been raised over the past 2 years. Will this trend continue or has it already reached its peak? The answer d...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/PRS.0000000000004809
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Treating patients with Raynaud's phenomenon who have chronic pain and ulcerations is extremely challenging. Unrelenting pain can lead to dysfunction and disuse, rendering the patient debilitated and/or chronically depressed. Pharmacologic vasodilators and surgical sympathectomies offer variable benefits. Out...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/PRS.0b013e3181a80576
更新日期：2009-07-01 00:00:00
abstract：:The 47-kDa heat shock protein (HSP47) is a molecular chaperone specifically targeting the processing and quality control of collagen molecules. This study was performed to investigate whether antisense therapy preventing HSP47 expression might affect the scar formation occurring during wound healing of skin. In wound ...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/01.PRS.0000054844.41243.F2
更新日期：2003-05-01 00:00:00
abstract：:This study is an economic comparison of various methods of breast reconstruction after mastectomy. The hospital bills of 287 patients undergoing breast reconstruction at three institutions from June of 1988 to March of 1991 were analyzed. The procedures examined included mastectomy, implant and tissue-expander reconst...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/00006534-199307000-00011
更新日期：1993-07-01 00:00:00
abstract：:Defects of the heel and sole represent difficult reconstructive problems in terms of tissue availability and postoperative morbidity. Although local flaps offer the optimal type of coverage, their application has been restricted to defects of limited size. A study of the plantar skin and fascia, as well as its neurova...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/00006534-198008000-00014
更新日期：1980-08-01 00:00:00
abstract：:A surgical procedure is described for the definitive treatment of trochanteric decubitus ulcers. It combines the advantages of the bipedicle skin flap and the musculocutaneous flap; that is, a large area of skin is provided with a thick protective padding consisting of fat, fascia, and muscle richly vascularized by th...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/00006534-198011000-00011
更新日期：1980-11-01 00:00:00
abstract：:The titanium hollow screw reconstruction plate (THORP) system for reconstruction of lower jaw defects provides a functional stable fixation and is used as a long-term or permanent implant in tumor surgery and in traumatology. The rigid fixation of the head of the screw to the plate, avoiding unphysiologic loads to the...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/00006534-198811000-00013
更新日期：1988-11-01 00:00:00
abstract：:The purpose of this study was to gain information which might be helpful in understanding the influence of palate surgery on abnormal maxillary growth. The finding of actin-rich cells in the granulation tissue of palatal wounds supports the hypothesis that one of the functions of those cells is contraction--and the la...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/00006534-197809000-00015
更新日期：1978-09-01 00:00:00
abstract：:Partial amputations of the hind legs were done in 44 rats. The femoral arteries and veins were repaired by microvascular techniques. The systemic use of heparin, the local use of magnesium sulfate, and the combined use of the two drugs, were evaluated as to their influence on preventing thrombosis in these microvascul...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/00006534-197505000-00018
更新日期：1975-05-01 00:00:00
abstract：BACKGROUND:Although multiple acellular dermal matrix sources exist, it is unclear how its processing impacts complication rates. The authors compared complications between two preparations of human cadaveric acellular dermal matrix (freeze dried and ready-to-use) in immediate tissue expander breast reconstruction to an...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/PRS.0000000000004323
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:The authors evaluated the use of national databases to track surgical complications among abdominoplasty and breast augmentation patients. METHODS:Their study population included all patients with abdominoplasty or breast augmentation in the Tracking Operations and Outcomes for Plastic Surgeons (TOPS) and C...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/PRS.0b013e3181bf8378
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Recent studies have demonstrated low levels of National Institutes of Health funding for surgical research. The authors compared the funding in plastic surgery with the funding for other surgical specialties. METHODS:A query of National Institutes of Health grants awarded to departments of surgical specialt...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/PRS.0000000000003866
更新日期：2017-12-01 00:00:00
abstract：:Free-tissue transfer has facilitated and refined the reconstructive surgeon's ability to repair or reconstruct acquired or congenital defects in children. Although parallels exist between indications for free-tissue transfer in adults and children, the technical challenges and surgical skill required in pediatric pati...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/PRS.0b013e3181bf83f1
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Lipofilling is a treatment modality to restore tissue volume. Both platelet-rich plasma and adipose-derived stromal cells have been reported to augment the efficacy of lipofilling, yet results are not conclusive. The authors hypothesized that the variation reported in literature is caused by a dose-dependent...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/01.prs.0000479995.04255.bb
更新日期：2016-03-01 00:00:00
abstract：:Current literature recommends the use of a carbon dioxide laser for excision of lesions where minimal damage and wound contracture are desirable. The extent of tissue damage is evaluated as a correlate of percentage of split-thickness skin graft "take" following excision of full-thickness skin with scalpel, electrocut...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/00006534-198006000-00002
更新日期：1980-06-01 00:00:00
abstract：:Multicenter clinical trials are important research tools. Planning a multicenter clinical trial is a long and arduous task that requires substantial preparation time. In this guide, the authors discuss the steps used to plan a multicenter clinical trial. A preplanning phase, which involves formulating and refining a r...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章,评审
doi：10.1097/PRS.0b013e3181df64fa
更新日期：2010-08-01 00:00:00
abstract：:The traditional reason for performing aesthetic surgery in the forehead and brow area has been to correct brow ptosis. However, there are several other conditions that may be improved by surgery in this area, including frown muscle imbalance, transverse forehead rhytids, and lateral brow laxity. Recently, a better und...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:Abdominally based free tissue transfer (FTT) and latissimus dorsi and immediate fat transfer (LIFT) procedures are both fully autologous options for breast reconstruction. The former is specialized and requires comfort with microsurgical technique, whereas LIFT combines a common set of techniques familiar to...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/PRS.0000000000007027
更新日期：2020-08-01 00:00:00
abstract：:A very rare case of congenital skin tube pedicle with congenital constriction band syndrome was presented. Only one report concerning this bizarre abnormality could be found in the available literature, and no consideration of its etiology has previously been published. In our case, the skin tube was accompanied by th...
journal_title：Plastic and reconstructive surgery
pub_type： 杂志文章
doi：10.1097/00006534-199204000-00029
更新日期：1992-04-01 00:00:00
