Baclofen overdose in two siblings.

Abstract:

:Baclofen is a muscle relaxant used in both adults and children with neuromuscular disorders to control spasticity. In children, relatively few cases of overdose have been previously reported. We report two cases of baclofen overdose occurring in two siblings. One sibling with cerebral palsy was being treated with baclofen at the time of overdose. Both cases presented with severe respiratory depression requiring mechanical ventilation. Serum baclofen concentrations from both children were significantly elevated. We also review the published literature on baclofen overdose in children and adolescents. These cases emphasize the importance of warning parents about the potential toxicity of baclofen when prescribing the drug to a family member.

journal_name

Pediatr Emerg Care

journal_title

Pediatric emergency care

authors

Chapple D,Johnson D,Connors R

doi

10.1097/00006565-200104000-00008

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

110-2

issue

2

eissn

0749-5161

issn

1535-1815

journal_volume

17

pub_type

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