Abstract:
:Recently published studies suggest a benefit for androgen deprivation therapy (ADT) delivered early in the course of prostate cancer. However, the use of ADT specifically in patients with clinically localized disease or biochemical-disease recurrence after local therapy is not well defined. Potential candidates for primary ADT include patients who are poor candidates for definitive local therapy because of advanced age or comorbid conditions, as well as patients with significant local disease who refuse standard therapy. Treatment strategies designed to minimize the side effects of prolonged therapy, such as intermittent ADT or antiandrogen monotherapy, show promise as alternatives to continuous ADT in some patients. The role of ADT in patients with clinically localized and recurrent prostate cancer, whether it is delivered in a continuous or intermittent fashion, must be determined in randomized, prospective trials.
journal_name
Urologyjournal_title
Urologyauthors
Grossfeld GD,Small EJ,Lubeck DP,Latini D,Broering JM,Carroll PRdoi
10.1016/s0090-4295(01)01243-2subject
Has Abstractpub_date
2001-08-01 00:00:00pages
56-64issue
2 Suppl 1eissn
0090-4295issn
1527-9995pii
S0090429501012432journal_volume
58pub_type
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