Androgen deprivation therapy for patients with clinically localized (stages T1 to T3) prostate cancer and for patients with biochemical recurrence after radical prostatectomy.

Abstract:

:Recently published studies suggest a benefit for androgen deprivation therapy (ADT) delivered early in the course of prostate cancer. However, the use of ADT specifically in patients with clinically localized disease or biochemical-disease recurrence after local therapy is not well defined. Potential candidates for primary ADT include patients who are poor candidates for definitive local therapy because of advanced age or comorbid conditions, as well as patients with significant local disease who refuse standard therapy. Treatment strategies designed to minimize the side effects of prolonged therapy, such as intermittent ADT or antiandrogen monotherapy, show promise as alternatives to continuous ADT in some patients. The role of ADT in patients with clinically localized and recurrent prostate cancer, whether it is delivered in a continuous or intermittent fashion, must be determined in randomized, prospective trials.

journal_name

Urology

journal_title

Urology

authors

Grossfeld GD,Small EJ,Lubeck DP,Latini D,Broering JM,Carroll PR

doi

10.1016/s0090-4295(01)01243-2

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

56-64

issue

2 Suppl 1

eissn

0090-4295

issn

1527-9995

pii

S0090429501012432

journal_volume

58

pub_type

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