In vivo efficacy of antimicrobe-impregnated saline-filled silicone implants.

Abstract:

:Bacterial colonization of mammary implants is a prelude to clinical infection and has been implicated in the etiology of capsular contracture. Antimicrobial impregnation of a variety of medical devices with the combination of minocycline and rifampin has recently emerged as a potentially effective method for preventing device colonization and device-related infection. The objective of this animal study was to examine in vivo the antimicrobial efficacy of minocycline/rifampin-impregnated, saline-filled silicone implants. A rabbit model of Staphylococcus aureus colonization and infection of subcutaneously placed implants was used. A total of 48 saline-filled silicone implants (24 antimicrobe-impregnated and 24 control unimpregnated implants) were suspended in a 106 colony-forming units/ml bacterial suspension of S. aureus for 30 minutes at room temperature, allowed to dry for 60 minutes, and then implanted subcutaneously in the back of 12 rabbits (two antimicrobe-impregnated and two control implants were placed in each rabbit). Rabbits were monitored daily, then killed either at 2 weeks (10 rabbits) or at 4 weeks (two rabbits) and cultured. The antimicrobe-impregnated implants were 12 times less likely to be colonized than control unimpregnated implants (two of 24 versus 23 of 24; p < 0.001), and they were a significantly less likely cause of implant-related infection (0 of 24 versus 22 of 24; p < 0.001) and implant-related abscess (0 of 24 versus 21 of 24; p < 0.001) than control implants. The minocycline/rifampin-impregnated implants routinely demonstrated zones of inhibition against S. aureus at the time of explantation. These results indicate that minocycline/rifampin-impregnated implants can significantly decrease the rate of bacterial colonization, implant-related infection, and implant-related abscess. Antimicrobe-impregnated implants also have the potential of reducing the likelihood of capsular contracture.

journal_name

Plast Reconstr Surg

authors

Darouiche RO,Meade R,Mansouri MD,Netscher DT

doi

10.1097/00006534-200204010-00022

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

1352-7

issue

4

eissn

0032-1052

issn

1529-4242

journal_volume

109

pub_type

杂志文章
  • Myocutaneous free-flap transfer. Anatomical and experimental considerations.

    abstract::If there is a strongly dominant vascular pedicle, a muscle may be suitable for transfer as a free myocutaneous flap. The minor vascular pedicle(s) may contribute significantly to the arterial blood flow to the overlying skin, however. The concept of doing a delay procedure (ligating the dominant pedicle) to increase t...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197808000-00002

    authors: Mathes SJ,Vasconez LO

    更新日期:1978-08-01 00:00:00

  • Anatomy of the corrugator supercilii muscle: part I. Corrugator topography.

    abstract:BACKGROUND:Complete corrugator supercilii muscle resection is important for the surgical treatment of migraine headaches and may help prevent postoperative abnormalities in surgical forehead rejuvenation. Specific topographic analysis of corrugator supercilii muscle dimensions and its detailed association with the supr...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000282725.61640.e1

    authors: Janis JE,Ghavami A,Lemmon JA,Leedy JE,Guyuron B

    更新日期:2007-11-01 00:00:00

  • Management of Vascular Anomalies and Related Conditions Using Suction-Assisted Tissue Removal.

    abstract:UNLABELLED:Vascular anomalies and related conditions cause overgrowth of tissues. The purpose of this study was to determine the efficacy and safety of liposuction techniques for pediatric overgrowth diseases. Patients treated between 2007 and 2015 who had follow-up were reviewed. Seventeen patients were included; the ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000001558

    authors: Couto JA,Maclellan RA,Greene AK

    更新日期:2015-10-01 00:00:00

  • Further evaluation of the potential of the argon laser in the treatment of strawberry hemangiomas.

    abstract::Six cases of strawberry hemangioma have been presented in which some form of intervention in tumor progression was indicated. The argon laser was used. All six cases showed loss of surface vascularity. Growth was clearly arrested in four of the six. Premature regression could be definitely claimed in only one. The str...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198304000-00005

    authors: Hobby LW

    更新日期:1983-04-01 00:00:00

  • Head and neck reconstruction with the latissimus dorsi myocutaneous flap: anatomic observations and report of 60 cases.

    abstract::The latissimus dorsi myocutaneous flap can be employed successfully in head and neck reconstruction when the size or nature of the defect precludes the use of local or regional flaps. Generous amounts of hairless skin and muscle may be transferred in one operative procedure while producing an acceptable donor defect. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198302000-00009

    authors: Barton FE Jr,Spicer TE,Byrd HS

    更新日期:1983-02-01 00:00:00

  • Surgical decompression of the great auricular nerve: a therapeutic option for neurapraxia following rhytidectomy.

    abstract:BACKGROUND:Great auricular nerve injuries are the most frequent nerve injuries following rhytidectomy, occurring at a rate of 6 percent. Short-scar techniques may decrease visualization and increase the risk of injury/compression of the great auricular nerve. Recent reviews have identified that great auricular nerve in...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000436861.85892.a1

    authors: Barbour JR,Iorio ML,Halpern DE

    更新日期:2014-02-01 00:00:00

  • Dermal suspension and parenchymal reshaping mastopexy after massive weight loss: statistical analysis with concomitant procedures from a prospective registry.

    abstract:BACKGROUND:An increasing number of women are presenting for mastopexy after massive weight loss. The authors analyzed data from a prospective registry of massive weight loss patients who underwent the dermal suspension and parenchymal reshaping mastopexy alone or with concomitant operations to assess safety and efficac...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e31819ba1a8

    authors: Rubin JP,Gusenoff JA,Coon D

    更新日期:2009-03-01 00:00:00

  • Reconstruction of oncologic tibial defects in children using vascularized fibula flaps.

    abstract:BACKGROUND:Tibial resection in children presents a unique reconstructive challenge because of technical demands, future growth potential, and repetitive loading of the lower extremity. Positioned in a tibial defect, the free fibula undergoes primary bone healing while maintaining intrinsic resistance to infection and t...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e318230e463

    authors: Schwarz GS,Disa JJ,Mehrara BJ,Healey JH,Cordeiro PG

    更新日期:2012-01-01 00:00:00

  • Airway disorders in hemifacial microsomia.

    abstract::The anatomic components of hemifacial microsomia have been classified previously, but their relevance to functional abnormalities has not been stressed. In a recent review of the literature, we found that the frequency and severity of airway disorders, especially those leading to upper airway obstruction and/or obstru...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199901000-00006

    authors: Cohen SR,Levitt CA,Simms C,Burstein FD

    更新日期:1999-01-01 00:00:00

  • A placebo-controlled surgical trial of the treatment of migraine headaches.

    abstract:BACKGROUND:Many of the nearly 30 million Americans suffering with migraine headaches are not helped by standard therapies, a proportion of which can harbor undesirable side effects. The present study demonstrates the efficacy of independent surgical deactivation of three common migraine headache trigger sites through a...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/PRS.0b013e3181adcf6a

    authors: Guyuron B,Reed D,Kriegler JS,Davis J,Pashmini N,Amini S

    更新日期:2009-08-01 00:00:00

  • Repair of Tessier no. 3 and no. 4 craniofacial clefts with facial unit and muscle repositioning by midface rotation advancement without Z-plasties.

    abstract:BACKGROUND:The accepted surgical correction of Tessier no. 3 and no. 4 craniofacial clefts is the use of interdigitating skin flaps along the line of the facial cleft, which frequently results in unsightly facial scars, poor skin color match, and an unnatural facial expression. The authors report their technique of mid...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e31824ec310

    authors: Chen PK,Chang FC,Chan FC,Chen YR,Noordhoff MS

    更新日期:2012-06-01 00:00:00

  • Does breast reconstruction after mastectomy for breast cancer affect overall survival? Long-term follow-up of a retrospective population-based cohort.

    abstract:BACKGROUND:This study compared overall and breast cancer-specific survival using long-term follow-up data among women diagnosed with invasive breast cancer undergoing mastectomy or breast reconstruction. METHODS:Retrospective study using population-based data from Ontario Cancer Registry (1980 to 1990) including women...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/PRS.0000000000001054

    authors: Platt J,Baxter NN,McLaughlin J,Semple JL

    更新日期:2015-03-01 00:00:00

  • Keloids have continuous high metabolic activity.

    abstract::The adenosine triphosphate (ATP) content of keloids and scars resected from patients was demonstrated by high-performance liquid chromatography. The surface color of hypertrophic scars was red or pink and that of atrophic scars was white. The ATP content of red scars was (in mmol/g protein) 1.06 +/- 0.14, of pink scar...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199909030-00012

    authors: Ueda K,Furuya E,Yasuda Y,Oba S,Tajima S

    更新日期:1999-09-01 00:00:00

  • Treatment of axillary burn scar contracture using an arterialized scapular island flap.

    abstract::A case of an axillary burn scar contracture treated with a scapular island flap is presented. We believe that this will be a useful addition to the treatment of burn scar contractures of the axilla. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198309000-00024

    authors: Dimond M,Barwick W

    更新日期:1983-09-01 00:00:00

  • Surgical correction of gynecomastia.

    abstract:SUMMARY:Gynecomastia, or persistent enlargement of the male breast, is a common occurrence during early sexual development. Typically, two types of tissue can be identified during this period of growth. Initially, a dense fibrous growth of supporting stroma and breast tissue forms directly under the areola, creating a ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181aa2dc7

    authors: Hammond DC

    更新日期:2009-07-01 00:00:00

  • The role of acellular dermal matrices in capsular contracture: a review of the evidence.

    abstract::Despite advances in breast implant surgery, capsular contracture remains a challenging sequela of reconstructive and cosmetic breast implant surgery. Although there are established modalities for treatment, most recently, acellular dermal matrix products have been suggested to have a role in preventing or diminishing ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0b013e318262df58

    authors: Basu CB,Jeffers L

    更新日期:2012-11-01 00:00:00

  • Incidence of cleft palate fistula: an institutional experience with two-stage palatal repair.

    abstract::The purpose of this study was to determine the incidence of cleft palatal fistula in a series of nonsyndromic children treated at the authors' institution. This retrospective analysis of 103 patients with cleft palate treated by five surgeons between 1982 and 1995 includes 60 boys and 33 girls, whose median age was 18...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200111000-00011

    authors: Muzaffar AR,Byrd HS,Rohrich RJ,Johns DF,LeBlanc D,Beran SJ,Anderson C,Papaioannou aA A

    更新日期:2001-11-01 00:00:00

  • Google Glass as an Alternative to Standard Fluoroscopic Visualization for Percutaneous Fixation of Hand Fractures: A Pilot Study.

    abstract::This pilot study investigated the feasibility of Google Glass to assist visualization of fluoroscopic images during percutaneous pinning of hand fractures. Cadavers were used to compare total time to pin each fracture and total number of radiographs per fracture from a mini C-arm. A FluoroScan monitor was used for rad...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000001453

    authors: Chimenti PC,Mitten DJ

    更新日期:2015-08-01 00:00:00

  • High-dose-rate brachytherapy for the treatment of recalcitrant keloids: a unique, effective treatment protocol.

    abstract:BACKGROUND:Keloids cause aesthetic disfigurement and physical complaints, mainly pain and pruritus. Treatment of these scars is difficult, with high recurrence rates forming the main issue. Surgical excision with adjuvant radiotherapy is considered the most efficacious treatment. At their institution, the authors have ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/PRS.0000000000000415

    authors: van Leeuwen MCE,Stokmans SC,Bulstra AJ,Meijer OWM,van Leeuwen PAM,Niessen FB

    更新日期:2014-09-01 00:00:00

  • Metopic synostosis: evaluation of aesthetic results.

    abstract::Analysis of intermediate- and long-term results of surgical treatment of metopic synostosis is lacking. We therefore retrospectively studied 23 patients with metopic synostosis (14 males, 9 females) who have been followed from 3 months to 8.1 years (mean 42.5 months) after operation. Age at first operation ranged from...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Cohen SR,Maher H,Wagner JD,Dauser RC,Newman MH,Muraszko KM

    更新日期:1994-11-01 00:00:00

  • Long-Term Outcomes of Total Knee Arthroplasty following Soft-Tissue Defect Reconstruction with Muscle and Fasciocutaneous Flaps.

    abstract:BACKGROUND:Insufficient soft-tissue coverage following total knee arthroplasty jeopardizes prosthesis retention and may lead to significant complications. The aim of this study was to evaluate the natural history of total knee arthroplasty following flap reconstruction of soft-tissue defects. METHODS:A retrospective r...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000001929

    authors: Kwiecien GJ,Lamaris G,Gharb BB,Murray T,Hendrickson MF,Zins JE,Isakov R

    更新日期:2016-01-01 00:00:00

  • Breast-conserving therapy in patients with a relatively large (T2 or T3) breast cancer: long-term local control and cosmetic outcome of a feasibility study.

    abstract::Breast-conserving therapy is widely accepted as an appropriate method of primary treatment of T1 and T2 breast cancers that measure up to 5 cm. For safe and cosmetically acceptable breast-conserving therapy in patients with larger breast cancers, the tumor volume has to be reduced preoperatively, and lost tissue volum...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000117191.10766.95

    authors: Woerdeman LA,Hage JJ,Thio EA,Zoetmulder FA,Rutgers EJ

    更新日期:2004-05-01 00:00:00

  • Innovations in prosthetic interfaces for the upper extremity.

    abstract::Advancements in modern robotic technology have led to the development of highly sophisticated upper extremity prosthetic limbs. High-fidelity volitional control of these devices is dependent on the critical interface between the patient and the mechanical prosthesis. Recent innovations in prosthetic interfaces have fo...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0b013e3182a97e5f

    authors: Kung TA,Bueno RA,Alkhalefah GK,Langhals NB,Urbanchek MG,Cederna PS

    更新日期:2013-12-01 00:00:00

  • Evaluation of a simplified water mattress in the prevention and treatment of pressure sores.

    abstract::Using a simplified pressure-measuring device, we determined the pressures under 4 anatomical sites in 11 human subjects to compare 3 commercially available sleeping surfaces. The 3 surfaces tested were a water mattress, a water bed, and our standard hospital bed. There were no significant differences in the recorded p...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197710000-00016

    authors: Sloan DF,Brown RD,Larson DL

    更新日期:1977-10-01 00:00:00

  • An examination of the phenol-croton oil peel: part IV. Face peel results with different concentrations of phenol and croton oil.

    abstract::In Part IV of this examination of the phenol-croton oil peel, the author presents peeling solutions using phenol in concentrations between 16% and 50% as the carrier for croton oil. Previously, in Part I, the author showed that phenol alone in concentrations of less than 50% has no significant peeling effect on the sk...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200003000-00035

    authors: Hetter GP

    更新日期:2000-03-01 00:00:00

  • Congenital midline nasal muscle with associated nasal deformity.

    abstract::A case is presented of a congenital nasal deformity consisting of a midline nasal muscle, alar cartilage defect, and partially obstructed nostril. The embryology of nasal development is reviewed, and an attempt is made to explain this unique anomaly. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198103000-00015

    authors: Bauer BS,Kernahan DA

    更新日期:1981-03-01 00:00:00

  • Multiple occurrence of pilomatrixoma.

    abstract::Multiple occurrences of pilomatrixoma are rare. Although it has been known as a benign lesion, there are reports of some tumors that have histopathologic features of malignancy. A case of a 68-year-old Caucasian women with multiple pilomatrixoma is presented. She was operated on to remove three other pilomatrixomas on...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199609000-00024

    authors: Aslan G,Erdoğan B,Aköz T,Görgü M,Seçkin S,Terzioğlu A

    更新日期:1996-09-01 00:00:00

  • Change Is Happening: An Evaluation of Gender Disparities in Academic Plastic Surgery.

    abstract:BACKGROUND:Gender disparities in academic plastic surgery are known; however, recently, professional societies have endorsed a culture of gender diversification. This study aims to evaluate the effects of these changes at faculty and leadership positions. METHODS:A cross-sectional study was conducted in June of 2018 t...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000006086

    authors: Smith BT,Egro FM,Murphy CP,Stavros AG,Kenny EM,Nguyen VT

    更新日期:2019-10-01 00:00:00

  • Facial skeletal expansion: treatment strategies and rationale.

    abstract::Forty-three nonconsecutive patients presenting with dentofacial deformity underwent surgical procedures designed intentionally to create skeletal disproportion in the sagittal and/or vertical dimensions. This was accomplished through expansion (enlargement) of the facial skeleton beyond normative standards. At the tim...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199205000-00004

    authors: Rosen HM

    更新日期:1992-05-01 00:00:00

  • Role of upper lateral cartilage tension spanning suture in restoring the dorsal aesthetic lines in rhinoplasty.

    abstract::Dorsal hump reduction can lead to significant aesthetic and functional deformities with distortion of the dorsal aesthetic lines without first preserving and subsequently restoring proper position of the upper lateral cartilages. The senior author (R.J.R.) previously described the component dorsal hump reduction to pr...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3182a01470

    authors: Geissler PJ,Roostaeian J,Lee MR,Unger JJ,Rohrich RJ

    更新日期:2014-01-01 00:00:00