Erythromycin-associated ergotamine intoxication: arteriographic and electrophysiologic analysis of a rare cause of severe ischemia of the lower extremities and associated ischemic neuropathy.

Abstract:

:Vasospasm associated with ergotamine is a well-known phenomenon. In this case report we present a rare drug interaction between erythromycin and ergotamine at normal doses causing lower extremity ischemia in a 36-year-old woman. Nitroprusside proved to be the treatment of choice. The response was dramatic and took place in a matter of hours in this patient. Ischemic monomelic neuropathy is a recently described entity in which axonal necrosis is caused by a loss of distal extremity blood flow. The association between erythromycin and ergotamine may be a dangerous pharmacologic combination; drugs that have a hepatic cycle with ergotamine derivatives must be used with caution.

journal_name

Ann Vasc Surg

authors

Ghali R,De Léan J,Douville Y,Noël HP,Labbé R

doi

10.1007/BF02000258

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

291-6

issue

3

eissn

0890-5096

issn

1615-5947

pii

S0890-5096(06)60265-3

journal_volume

7

pub_type

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