Directional evolution for microsatellite size in maize.

abstract：:Quercus petraea and Quercus robur are two closely related oak species that frequently hybridize. We sequenced 70 clones containing the 5.8S and ITS2 regions of ribosomal DNA (rDNA) from these two species and did not detect a species-specific difference. Surprisingly, three divergent (up to 12.6%) rDNA families were id...

journal_title：Molecular biology and evolution

authors： Muir G,Fleming CC,Schlötterer C

更新日期：2001-02-01 00:00:00

abstract：:Estimation of evolutionary distances from coding sequences must take into account protein-level selection to avoid relative underestimation of longer evolutionary distances. Current modeling of selection via site-to-site rate heterogeneity generally neglects another aspect of selection, namely position-specific amino ...

journal_title：Molecular biology and evolution

authors： Halpern AL,Bruno WJ

更新日期：1998-07-01 00:00:00

abstract：:MicroRNA (miRNA) sponges are vital components of posttranscriptional gene regulation. Yet, only a limited number of miRNA sponges have been identified. Here, we show that the recently evolved noncoding tumor suppressor transcript, antisense RNA to TP73 gene (TP73-AS1), functions as a natural sponge of human-specific m...

journal_title：Molecular biology and evolution

authors： Hu H,Liu JM,Hu Z,Jiang X,Yang X,Li J,Zhang Y,Yu H,Khaitovich P

更新日期：2018-05-01 00:00:00

abstract：:This study is a geographically systematic genetic survey of the easternmost subspecies of chimpanzee, Pan troglodytes schweinfurthii. DNA was noninvasively collected in the form of shed hair from chimpanzees of known origin in Uganda, Rwanda, Tanzania, and Zaïre. Two hundred sixty-two DNA sequences from hypervariable ...

journal_title：Molecular biology and evolution

authors： Goldberg TL,Ruvolo M

更新日期：1997-09-01 00:00:00

abstract：:Cellular Ca(2+) homeostasis is tightly regulated and is pivotal to life. Inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs) are the major ion channels that regulate Ca(2+) release from intracellular stores. Although these channels have been extensively investigated in multicellular organisms...

journal_title：Molecular biology and evolution

authors： Alzayady KJ,Sebé-Pedrós A,Chandrasekhar R,Wang L,Ruiz-Trillo I,Yule DI

更新日期：2015-09-01 00:00:00

abstract：:Pseudogenes are nonfunctional relics of formerly functional genes and are thought to evolve neutrally. In some pseudogenes, however, the molecular evolutionary patterns are atypical of neutrally evolving sequences, exhibiting sequence conservation, codon-usage bias, and other features associated with functional genes....

journal_title：Molecular biology and evolution

authors： Podlaha O,Zhang J

更新日期：2004-12-01 00:00:00

abstract：:The order of genes on eukaryotic chromosomes is nonrandom. Some neighboring genes show order conservation among species, while some neighboring genes separate during evolution. Here, we investigated whether neighboring genes show interactions after their separation. We found that neighboring gene pairs tend to show in...

journal_title：Molecular biology and evolution

authors： Dai Z,Xiong Y,Dai X

更新日期：2014-05-01 00:00:00

abstract：:Forty-six strains derived from American and French natural populations of Drosophila melanogaster were tested for the presence and activity of hobo elements by using Southern blotting and a gonadal dysgenesis assay. The oldest available strains exhibited weak detectable hybridization to the hobo-element probe and reve...

journal_title：Molecular biology and evolution

authors： Pascual L,Periquet G

更新日期：1991-05-01 00:00:00

abstract：:Unraveling how regulatory divergence contributes to species differences and adaptation requires identifying functional variants from among millions of genetic differences. Analysis of allelic imbalance (AI) reveals functional genetic differences in cis regulation and has demonstrated differences in cis regulation with...

journal_title：Molecular biology and evolution

authors： Graze RM,Novelo LL,Amin V,Fear JM,Casella G,Nuzhdin SV,McIntyre LM

更新日期：2012-06-01 00:00:00

abstract：:The nucleotide sequences of the 5'-flanking regions of the duplicated Amy genes in eight sibling species belonging to the melanogaster species subgroup are analyzed. In Drosophila melanogaster, a region of about 450 bp immediately upstream of the translation initiation site of the two paralogous genes (the proximal an...

journal_title：Molecular biology and evolution

authors： Okuyama E,Shibata H,Tachida H,Yamazaki T

更新日期：1996-04-01 00:00:00

abstract：:Epigenetic information, which can be passed on independently of the DNA sequence, is stored in part in the form of histone posttranslational modifications and specific histone variants. Although complexes necessary for deposition have been identified for canonical and variant histones, information regarding the chroma...

journal_title：Molecular biology and evolution

authors： Ashraf K,Nabeel-Shah S,Garg J,Saettone A,Derynck J,Gingras AC,Lambert JP,Pearlman RE,Fillingham J

更新日期：2019-05-01 00:00:00

abstract：:Many species, including humans, have dramatically expanded their range in the past, and such range expansions had certainly an impact on their genetic diversity. For example, mutations arising in populations at the edge of a range expansion can sometimes surf on the wave of advance and thus reach a larger spatial dist...

journal_title：Molecular biology and evolution

authors： Klopfstein S,Currat M,Excoffier L

更新日期：2006-03-01 00:00:00

abstract：:We review all instances in which the nuclear 5S rRNA genes of fungi, protist, nematode, and arthropod species have been reported to be linked to the tandemly repeated units of the rDNA, trans-spliced leader, and histone multigene families. The evolution of these gene arrangements is analyzed by mapping them to indepen...

journal_title：Molecular biology and evolution

authors： Drouin G,de Sá MM

更新日期：1995-05-01 00:00:00

abstract：:Complex metazoan bodies require cell-to-cell communication for development, a process often mediated by signaling molecules binding to specific receptors. Relatively few signaling pathways have been recruited during evolution to build multicellular animals from unicellular zygotes. Of these few signaling pathways, one...

journal_title：Molecular biology and evolution

authors： Bertrand S,Iwema T,Escriva H

更新日期：2014-02-01 00:00:00

abstract：:Non-long terminal repeat retroelements continue to impact the human genome through cis-activity of long interspersed element-1 (LINE-1 or L1) and trans-mobilization of Alu. Current activity is dominated by modern subfamilies of these elements, leaving behind an evolutionary graveyard of extinct Alu and L1 subfamilies....

journal_title：Molecular biology and evolution

authors： Wagstaff BJ,Kroutter EN,Derbes RS,Belancio VP,Roy-Engel AM

更新日期：2013-01-01 00:00:00

abstract：:Full-length L1 elements have been shown to possess, at their 5' end, tandem repeats called "A" or "F" types. By sequencing the 5' region of two large L1 copies that did not hybridize to A or F probes, we have identified a new sequence that is found at the 5' end of many L1 elements and that we call "V." The element ch...

journal_title：Molecular biology and evolution

authors： Jubier-Maurin V,Cuny G,Laurent AM,Paquereau L,Roizes G

更新日期：1992-01-01 00:00:00

abstract：:A statistical analysis of the nucleotide sequence variability in 14 published hepatitis B virus (HBV) genomes was carried out using parametric and nonparametric methods. A parametric statistical model revealed that the different regions of the genome differed significantly in their variability. The conclusion was supp...

journal_title：Molecular biology and evolution

authors： Lauder IJ,Lin HJ,Lau JY,Siu TS,Lai CL

更新日期：1993-03-01 00:00:00

abstract：:The genomes of many vertebrates show a characteristic heterogeneous distribution of GC content, the so-called GC isochore structure. The origin of isochores has been explained via the mechanism of GC-biased gene conversion (gBGC). However, although the isochore structure is declining in many mammalian genomes, the het...

journal_title：Molecular biology and evolution

authors： Mugal CF,Arndt PF,Ellegren H

更新日期：2013-07-01 00:00:00

abstract：:Ribosomal DNA (rDNA) is one of the most conserved genes in eukaryotes. The multiples copies of rDNA in the genome evolve in a concerted manner, through unequal crossing over and/or gene conversion, two mechanisms related to homologous recombination. Recombination increases local GC content in several organisms through...

journal_title：Molecular biology and evolution

authors： Escobar JS,Glémin S,Galtier N

更新日期：2011-09-01 00:00:00

abstract：:The cellobiose catabolic system of Escherichia coli K12 is being used to study the role of cryptic genes in evolution of new functions. Escherichia coli does not use beta-glucoside sugars; however, mutations in several loci can activate the cryptic bgl operon and permit growth on the beta-glucoside sugars arbutin and ...

journal_title：Molecular biology and evolution

authors： Kricker M,Hall BG

更新日期：1984-02-01 00:00:00

abstract：:Several recent analyses have used quartet-based methods to assess the congruence among phylogenies derived for large sets of genes from prokaryotic genomes. The principal conclusion from these studies is that lateral gene transfer (LGT) has blurred prokaryotic phylogenies to such a degree that the darwinian scheme of ...

journal_title：Molecular biology and evolution

authors： Daubin V,Ochman H

更新日期：2004-01-01 00:00:00

abstract：:A parsimony analysis was performed on restriction sites at the Hba-ps4 pseudogene locus within one of four inversions associated with mouse t haplotypes. The results suggest that all t haplotypes form a monophyletic group and that the in (17)4 inversion originated before the radiation of the Mus musculus species compl...

journal_title：Molecular biology and evolution

authors： Hammer MF,Silver LM

更新日期：1993-09-01 00:00:00

abstract：:The elongation factor 1 alpha (EF-1 alpha) has become widely employed as a phylogenetic marker for studying eukaryotic evolution. However, a disturbing problem, the artifactual polyphyly of ciliates, is always observed. It has been suggested that the addition of new sequences will help to circumvent this problem. Thus...

journal_title：Molecular biology and evolution

authors： Moreira D,Le Guyader H,Philippe H

更新日期：1999-02-01 00:00:00

abstract：:There are many more selectively constrained noncoding than coding nucleotides in the mammalian genome, but most mammalian noncoding DNA is subject to weak selection, on average. One of the most striking discoveries to have emerged from comparisons among mammalian genomes is the hundreds of noncoding elements of more t...

journal_title：Molecular biology and evolution

authors： Halligan DL,Oliver F,Guthrie J,Stemshorn KC,Harr B,Keightley PD

更新日期：2011-09-01 00:00:00

abstract：:The variation of amino acid substitution rates in proteins depends on several variables. Among these, the protein's expression level, functional category, essentiality, or metabolic costs of its amino acid residues may play an important role. However, the relative importance of each variable has not yet been evaluated...

journal_title：Molecular biology and evolution

authors： Rocha EP,Danchin A

更新日期：2004-01-01 00:00:00

abstract：:The shikimate dehydrogenases (SDH) represent a widely distributed enzyme family with an essential role in secondary metabolism. This superfamily had been previously subdivided into 4 enzyme groups (AroE, YdiB, SdhL, and RifI), which show clear biochemical and functional differences ranging from amino acid biosynthesis...

journal_title：Molecular biology and evolution

authors： Singh S,Stavrinides J,Christendat D,Guttman DS

更新日期：2008-10-01 00:00:00

abstract：:The authors of a recent manuscript in "Nature" claim to have discovered "universal trends" of amino acid gain and loss in protein evolution. Here, we show that this universal trend can be simply explained by a bias that is unavoidable with the 3-taxon trees used in the original analysis. We demonstrate that a rigorous...

journal_title：Molecular biology and evolution

authors： Goldstein RA,Pollock DD

更新日期：2006-07-01 00:00:00

abstract：:Hybridization is often considered maladaptive, but sometimes hybrids can invade new ecological niches and adapt to novel or stressful environments better than their parents. The genomic changes that occur following hybridization that facilitate genome resolution and/or adaptation are not well understood. Here, we exam...

journal_title：Molecular biology and evolution

authors： Smukowski Heil CS,DeSevo CG,Pai DA,Tucker CM,Hoang ML,Dunham MJ

更新日期：2017-07-01 00:00:00

abstract：:Recent studies have linked demographic changes and epidemiological patterns in bacterial populations using coalescent-based approaches. We identified 26 studies using skyline plots and found that 21 inferred overall population expansion. This surprising result led us to analyze the impact of natural selection, recombi...

journal_title：Molecular biology and evolution

authors： Lapierre M,Blin C,Lambert A,Achaz G,Rocha EP

更新日期：2016-07-01 00:00:00

abstract：:The 20 protein-coding amino acids are found in proteomes with different relative abundances. The most abundant amino acid, leucine, is nearly an order of magnitude more prevalent than the least abundant amino acid, cysteine. Amino acid metabolic costs differ similarly, constraining their incorporation into proteins. O...

journal_title：Molecular biology and evolution

authors： Krick T,Verstraete N,Alonso LG,Shub DA,Ferreiro DU,Shub M,Sánchez IE

更新日期：2014-11-01 00:00:00