当前位置： SCI文献检索 > BIOCHEMICAL PHARMACOLOGY期刊下所有文献 > Hypocholesterolemic properties of plant indoles. Inhibition of acyl-CoA:cholesterol acyltransferase activity and reduction of serum LDL/VLDL cholesterol levels by glucobrassicin derivatives.

Hypocholesterolemic properties of plant indoles. Inhibition of acyl-CoA:cholesterol acyltransferase activity and reduction of serum LDL/VLDL cholesterol levels by glucobrassicin derivatives.

Abstract：

:Studies were undertaken to investigate the effects of the plant compound indole-3-carbinol (I3C) and its acid condensation products, which are generated in the stomach following ingestion of I3C, on cholesterol homeostasis in mice. Individual acid condensation products were synthesized and purified by HPLC. In vitro experiments revealed that several of the acid condensation products effectively inhibited the enzyme acyl-CoA:cholesterol acyltransferase (ACAT), which is responsible for the conversion of free cholesterol to the cholesteryl ester, at micromolar concentrations. Since the inhibition of ACAT in vivo should reduce serum cholesterol levels, I3C was administered to mice, and the effects on serum cholesterol levels were evaluated. Total serum cholesterol levels were elevated by 29% in mice provided a 3% cholesterol-supplemented diet, but this elevation was attenuated significantly (P < or = 0.05) by approximately 50% when I3C (100 mg/kg/day) was added to this diet. This effect of I3C was entirely on low density lipoprotein (LDL)/very low density lipoprotein (VLDL) cholesterol, which was lowered significantly (P < or = 0.05) by approximately 30%. In summary, I3C lowered serum LDL/VLDL cholesterol levels in mice, and this effect was likely mediated by the inhibition of ACAT by some of the acid condensation products of I3C. These results provide a possible mechanism by which I3C-rich vegetables lower serum cholesterol levels.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Dunn SE,LeBlanc GA

doi

10.1016/0006-2952(94)90027-2

subject

Has Abstract

pub_date

1994-01-20 00:00:00

pages

359-64

issue

2

eissn

0006-2952

issn

1873-2968

pii

0006-2952(94)90027-2

journal_volume

47

pub_type

杂志文章

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