Development of a novel nonantigenic dermal implant composed of human placental collagen.

Abstract:

:Injectable bovine collagen has proven to be safe and effective for the treatment of contour defects for more than 20 years. After intradermal exposure to bovine collagen, the most commonly reported side effect is hypersensitivity (incidence of approximately 3 percent to test and approximately 1 to 2 percent to subsequent treatment). The main purpose of this study was to evaluate tissue response and antibody production in bovine collagen-sensitive patients who were treated with human collagen (predominantly type I) implant. Twenty-seven patients with confirmed hypersensitivity to bovine collagen received a depot of human collagen implant and then were treated for facial contour defects on two to five separate occasions over a 9- to 12-month period and followed through 36 months. Measurement of antibody titers indicated that none of the subjects receiving human collagen implant developed antibodies against human collagen, even in the presence of positive antibody titers against bovine collagen. Histologic examination of the depot sites in these patients showed only mild inflammation. These findings indicate that treatment with human collagen did not elicit an allergic response in these subjects who had confirmed hypersensitivity to bovine collagen.

journal_name

Plast Reconstr Surg

authors

Toman PD,Egbert BM,Thomas JA,DeLustro FA

doi

10.1097/01.prs.0000105649.69434.ef

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

1015-20; discussion 1021-3

issue

3

eissn

0032-1052

issn

1529-4242

journal_volume

113

pub_type

临床试验,杂志文章,多中心研究
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    authors: Courtiss EH,Choucair RJ,Donelan MB

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  • A Current Review of Synthetic Meshes in Abdominal Wall Reconstruction.

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    doi:

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    pub_type: 杂志文章

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    更新日期:2007-05-01 00:00:00

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    journal_title:Plastic and reconstructive surgery

    pub_type: 临床试验,杂志文章

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    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,meta分析,评审

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