Ketorolac prophylaxis against heterotopic ossification after hip replacement.

Abstract:

:Three hundred three patients undergoing total hip replacement were enrolled in a prospective, randomized, double-blind clinical study of heterotopic bone formation. All the procedures were primary arthroplasties done for osteoarthritis using an anterolateral approach. Patients with spondyloarthropathy, previous surgery, or previous head or pelvic trauma were excluded. A total of 152 patients received 60 mg of ketorolac intraoperatively and 30 mg every 8 hours for 5 doses postoperatively; another 151 patients received no prophylaxis for heterotopic bone formation. Patients in each group had similar postoperative courses. No complications related to ketorolac use were seen. There was significantly less heterotopic bone formation in the ketorolac-treated group. Severe heterotopic bone formation did not develop in any treated patient, as compared with 11 untreated patients. It is concluded that ketorolac is useful as prophylaxis to prevent heterotopic bone formation. Treatment with ketorolac is completed during hospitalization; therefore, compliance is ensured. This treatment is convenient, but not necessarily more effective than other treatments.

journal_name

Clin Orthop Relat Res

authors

Pritchett JW

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

162-5

issue

314

eissn

0009-921X

issn

1528-1132

pub_type

临床试验,杂志文章,随机对照试验
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