Abstract:
PURPOSE:To report the clinical features in a series of patients with perineural spread of squamous cell carcinoma involving periorbital nerves that presented with clinical and/or imaging evidence of pseudo-cystic transformation along the involved nerves. METHODS:A noncomparative, retrospective chart review of the clinical and imaging findings of patients attending a regional orbital surgery department between 1998 and 2005, presenting with a pseudo-cystic orbital mass on clinical examination and/or imaging, which proved to be due to perineural squamous cell carcinoma on histopathology. RESULTS:The study included 8 male patients with a mean age at referral of 66 +/- 11 years. All cases had associated cutaneous squamous cell carcinoma involving the face or scalp, and, in 4 cases, the primary tumor could be identified in the vicinity of the affected orbit. The duration of the symptoms varied from 5 weeks to 9 years (24 +/- 36 months). Altered sensation, including formication and hypo-esthesia in the V1 and V2 trigeminal division, motor nerve palsies, and ptosis in conjunction with a palpable periorbital mass, were the most common presentations. The cystic tumor deposits were assessed histologically with both hematoxylin and eosin and immunoperoxidase stains (S100 protein for neural structures identification and MNF116 as a keratin marker). This demonstrated malignant squamous epithelium both within and around the wall of the tumor deposit and, in continuity, within the nerve running through the lesion. Some nerves showed substantial areas of fibrosis, representing obliteration of the nerve structure caused by involvement by tumor. Treatment modalities included surgical debulking, exenteration, radiotherapy, and combined chemo-radiotherapy. Mean follow-up was 29 +/- 23 months. Eight patients (87.5%) remain alive, and five of them show no evidence of disease. One patient died after progression of the malignancy. CONCLUSIONS:The presence of a cystic lesion in association with sensory or motor deficit in the periorbital region should suggest a diagnosis of perineural spread from a cutaneous squamous cell carcinoma. Because these patients may present to the ophthalmologist first, an awareness of this entity is of critical importance to avoid the delayed diagnosis seen in half of our cases.
journal_name
Ophthalmic Plast Reconstr Surgjournal_title
Ophthalmic plastic and reconstructive surgeryauthors
Valenzuela AA,Whitehead KJ,Sullivan TJdoi
10.1097/01.iop.0000218259.19584.a8subject
Has Abstractpub_date
2006-05-01 00:00:00pages
201-5issue
3eissn
0740-9303issn
1537-2677pii
00002341-200605000-00011journal_volume
22pub_type
杂志文章abstract::We present the results of a pilot study of the use of Nd:Yag laser in the removal of permanent eyeliner tattoos. Fourteen eyelids were treated, and in all cases a reduction in pigmentation was achieved although responses were variable. The advantages of such therapy over existing techniques are described. The techniqu...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-199212000-00010
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abstract:PURPOSE:The purpose of this study is to explore mechanical and co-innervational factors involved in both voluntary and involuntary brow elevation among people affected by ptosis and dermatochalasis. METHODS:In this prospective cohort study of normal controls and eyelids with ptosis or dermatochalasis, marginal reflex ...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000001178
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journal_title:Ophthalmic plastic and reconstructive surgery
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doi:10.1097/IOP.0b013e3181f29d4d
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journal_title:Ophthalmic plastic and reconstructive surgery
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doi:10.1097/IOP.0b013e3181c4dff6
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journal_title:Ophthalmic plastic and reconstructive surgery
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doi:10.1097/IOP.0b013e3181bb5942
更新日期:2010-07-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-199911000-00009
更新日期:1999-11-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
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doi:10.1097/IOP.0b013e3181e4a770
更新日期:2011-01-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
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journal_title:Ophthalmic plastic and reconstructive surgery
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更新日期:2003-07-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
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doi:10.1097/IOP.0b013e318182b00f
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of silicone rod in tarsofrontalis sling surgery for severe congenital ptosis. METHODS:A prospective, case series study was performed in 46 patients (56 eyelids) who underwent tarsofrontalis sling surgery using silicone rod for severe congenital ptosis. The efficacy of the si...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3182a74f44
更新日期:2014-01-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
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doi:10.1097/01.iop.0000148409.31127.f5
更新日期:2005-01-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
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doi:10.1097/IOP.0b013e31823d2125
更新日期:2012-05-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e31820d1ac3
更新日期:2012-01-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
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doi:10.1097/01.iop.0000231549.24125.7a
更新日期:2006-09-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000692
更新日期:2017-05-01 00:00:00
abstract::A 6-year-old boy with Schwartz-Jampel syndrome and severe myotonia-induced blepharospasm and ptosis did not respond to botulinum toxin A injections in the orbicularis muscle. The clinical diagnosis was further supported by electromyography. Surgical management using a combination of techniques in one operation produce...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.iop.0000195008.15872.a0
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abstract::A mass that recurred after dacryocystectomy for benign squamous papilloma of the lacrimal sac was diagnosed as a high-grade mucoepidermoid carcinoma in a 53-year-old man on histopathology. Local excision to the orbital periosteum was performed and gave a margin free of invasion. Neither local recurrence nor systemic m...
journal_title:Ophthalmic plastic and reconstructive surgery
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doi:10.1097/IOP.0b013e3181eea4e4
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journal_title:Ophthalmic plastic and reconstructive surgery
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journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章,随机对照试验
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更新日期:2004-01-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
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更新日期:2016-03-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章,评审
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更新日期:2019-11-01 00:00:00
abstract:PURPOSE:To demonstrate the histopathologic characteristics of different types of lacrimal drainage system concretions with clinical correlations. METHODS:Thirty lacrimal drainage system concretions submitted to the Cogan Eye Pathology Laboratory at the Massachusetts Eye and Ear Infirmary over a 2-year period were revi...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e31824c88a6
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:To clinically characterize blepharoptosis in Hispanic New Mexicans with oculopharyngeal muscular dystrophy and examine eyelid surgery outcomes. METHODS:A retrospective noncomparative case series and retrospective, nonrandomized, comparative interventional case series was performed on medical records from 86 pa...
journal_title:Ophthalmic plastic and reconstructive surgery
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journal_title:Ophthalmic plastic and reconstructive surgery
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更新日期:2017-05-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.iop.0000159173.42243.ad
更新日期:2005-05-01 00:00:00
abstract::A basal cell carcinoma of the eyelid had unique and potentially confusing histopathologic features. The tumor displayed a carcinoma in situ pattern with replacement of an extensive segment of the tarsal epithelium by neoplastic basaloid cells, a finding to the best of the authors' knowledge that has not been previousl...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3181a33887
更新日期:2009-05-01 00:00:00
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journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00