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Increase in hybridization rates with oligodeoxyribonucleotides containing locked nucleic acids.

Abstract：

:Locked nucleic acids (LNAs) incorporated into either stable single stranded oligonucleotides containing tetraloops or their complements have been found to increase second order hybridization rate constants by an order of magnitude compared to the all-DNA hybridization rate constants. Model sequences composed of 20 bases in length that can form hairpins due to a stable GAAA tetraloop were used where LNAs were substituted for the nucleotides in the loop, stem, or end regions of the strand and in the complementary strand. Substitution of the LNAs to the loop predictably raised the melting temperatures of the duplex however, the hybridization rates between the tetraloop and the complementary sequence also increased. In contrast, when LNAs were substituted in the stem, the hybridization rate decreased implying the formation of a more stable hairpin. Substitution of LNAs into the end region of the sequence had little effect on the hybridization rate constants although melting temperatures still showed a predictable increase. Rates also increased when LNAs were substituted into complementary strands of DNA tetraloops. The increase in hybridization rate constant is being attributed to changes in the structure of the stable single strands.

journal_name

J Biomol Struct Dyn

journal_title

Journal of biomolecular structure & dynamics

authors

Ormond TK,Spear D,Stoll J,Mackey MA,St John PM

doi

10.1080/07391102.2006.10507110

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

171-82

issue

2

eissn

0739-1102

issn

1538-0254

pii

d=3024&c=4212&p=15233&do=detail

journal_volume

24

pub_type

杂志文章

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