Sedation analgesia during office-based plastic surgery procedures: comparison of two opioid regimens.

Abstract:

BACKGROUND:The combination of sedative and analgesic drugs is increasingly being used during minimally invasive surgery. The authors compared the clinical efficacy of two different fentanyl regimens, in combination with midazolam, for sedation analgesia in patients undergoing office-based plastic surgery procedures under local anesthesia. METHODS:One-hundred patients were randomized into two groups of 50 subjects each. Group F1 received a fentanyl bolus of 0.7 microg/kg before infiltration with local anaesthetics; group F2 received the same bolus plus 0.6 microg/kg fentanyl every 45 minutes. All patients received a midazolam bolus of 0.05 mg/kg plus continuous infusion 0.08 mg/kg per hour. RESULTS:High-quality analgesia was obtained in every group, without significant differences between the two fentanyl regimens. Group F2 was associated with lower intraoperative mean blood pressure and SpO2 values compared with group F1. No differences were detected between the two groups in perioperative side effects or postoperative pain. CONCLUSION:Higher doses of opioid did not improve the quality of perioperative patient comfort but acted synergistically with the sedative drugs, amplifying the hemodynamic and respiratory side effects.

journal_name

Plast Reconstr Surg

authors

Cinnella G,Meola S,Portincasa A,Parisi D,Morgese F,Pavone G,Dambrosio M

doi

10.1097/01.prs.0000260754.59310.38

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

2263-2270

issue

7

eissn

0032-1052

issn

1529-4242

pii

00006534-200706000-00042

journal_volume

119

pub_type

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