A theoretical model for transdermal drug delivery from emulsions and its dependence upon formulation.


:This article presents a theoretical model of transdermal drug delivery from an emulsion-type vehicle that addresses the vehicle heterogeneity and incorporates the prediction of drug transport parameters as function of the vehicle composition. The basic mass transfer model considers interfacial and diffusion resistances within the emulsion and partition/diffusion phenomena across two skin compartments in series. Drug transport parameters are predicted as follows: partition coefficients are derived from regular solutions theory, drug diffusivity in the continuous phase is computed from a free volume theory with segmental motion, and permeability of the surfactant layer around droplets is estimated based on a free surface area model. These relationships are incorporated within the basic mass transfer model, so that the overall model is able to predict temporal profiles of drug release from the vehicle and of drug concentration in plasma, as a function of vehicle composition. In this way, the proposed model provides a sound physicochemical basis to support the development of new formulations and the planning of experiments. A simulated case study regarding a nitroglycerin ointment is presented in detail, illustrating how thermodynamic and kinetic factors inherent to the emulsion vehicle can modulate drug release and subsequent systemic absorption.


J Pharm Sci


Bernardo FP,Saraiva PM




Has Abstract


2008-09-01 00:00:00














  • Monitoring the purity of pharmaceutical heparin preparations by high-field 1H-nuclear magnetic resonance spectroscopy.

    abstract::High-field (300 MHz) 1H NMR spectral analyses are reported for various sodium or calcium heparin products available on the Canadian market. Dermatan sulfate (chondroitin sulfate B) was detected as a contaminant in virtually all of these products. Its content varied among the suppliers from less than 1 to 15%, and also...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Neville GA,Mori F,Holme KR,Perlin AS

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  • Distribution and elimination of polymethyl methacrylate nanoparticles after peroral administration to rats.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Nefzger M,Kreuter J,Voges R,Liehl E,Czok R

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  • Absorption and bioavailability of glucosamine in the rat.

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    journal_title:Journal of pharmaceutical sciences

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    authors: Ibrahim A,Gilzad-kohan MH,Aghazadeh-Habashi A,Jamali F

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    authors: Ju W,Yang S,Ansede JH,Stephens CE,Bridges AS,Voyksner RD,Ismail MA,Boykin DW,Tidwell RR,Hall JE,Wang MZ

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    journal_title:Journal of pharmaceutical sciences

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    authors: Marasini N,Yan YD,Poudel BK,Choi HG,Yong CS,Kim JO

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Schrank S,Kann B,Windbergs M,Glasser BJ,Zimmer A,Khinast J,Roblegg E

    更新日期:2013-11-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ji JA,Zhang B,Cheng W,Wang YJ

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    journal_title:Journal of pharmaceutical sciences

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    authors: Kendrick BS,Dong A,Allison SD,Manning MC,Carpenter JF

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  • Contribution of Human Liver and Intestinal Carboxylesterases to the Hydrolysis of Selexipag In Vitro.

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    authors: Imai S,Ichikawa T,Sugiyama C,Nonaka K,Yamada T

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Thoman CJ

    更新日期:1986-10-01 00:00:00

  • Antitumor agents LVI: the protein synthesis inhibition by genkwadaphnin and yuanhuacine of P-388 lymphocytic leukemia cells.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: de Smidt JH,Fokkens JG,Grijseels H,Crommelin DJ

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    pub_type: 杂志文章


    authors: Bogardus JB

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Jasper JP,Zhang F,Poe RB,Linhardt RJ

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tokuma Y,Fujiwara T,Noguchi H

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  • Preparation and analysis of deuterium-labeled aspirin: application to pharmacokinetic studies.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Pedersen AK,FitzGerald GA

    更新日期:1985-02-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Gershon H,Shanks L,Clarke DD

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


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    更新日期:2013-06-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: de la Luz Reus Medina M,Kumar V

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Mizuma T,Kawashima K,Sakai S,Sakaguchi S,Hayashi M

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kayali I,Suhery T,Friberg SE,Simion FA,Rhein LD

    更新日期:1991-05-01 00:00:00