Abstract：
OBJECTIVES:To examine the expressions of transient receptor potential (TRP) channel A1 and TRPM8 in the human urogenital organs (urinary bladder and prostate) and how these expressions change in association with bladder outlet obstruction (BOO) or benign prostatic hyperplasia (BPH). In addition to TRPM8, a cool receptor, TRPA1 is recently recognized as a cold receptor. TRPA1 is also a candidate for mechanosensor and/or nociceptor. METHODS:Urinary bladder mucosa and muscular layer were taken from 9 controls and 9 patients with BOO. Prostatic specimens were obtained from 5 controls and 6 patients with BPH. Expressions of TRPA1 and TRPM8 messenger RNAs (mRNAs) were quantified by real-time revere transcriptase-polymerase chain reaction. Localization of TRPA1 protein was explored with immunohistochemistry. RESULTS:The expression levels of TRPA1 mRNA in the bladder mucosa, bladder muscular layer, and prostate were in the ratio of 639:1:16. TRPA1 mRNA in the bladder mucosa with BOO was significantly upregulated to 2.32 times of control. TRPA1 protein was localized in the epithelial cells of both urinary bladder and prostate gland. The expression of TRPM8 mRNA in the prostate was much higher than that in the bladder mucosa (3024:1), but was not found in the bladder muscle layer. BPH or BOO did not significantly affect the expression of TRPM8. CONCLUSIONS:TRPA1 and TRPM8 were differentially expressed in the human urinary bladder and prostate. TRPA1 in the bladder epithelium might be involved in the bladder sensory transduction and the induction process of overactive bladder by BOO.
journal_name
Urologyjournal_title
Urologyauthors
Du S,Araki I,Kobayashi H,Zakoji H,Sawada N,Takeda Mdoi
10.1016/j.urology.2007.11.127subject
Has Abstractpub_date
2008-08-01 00:00:00pages
450-5issue
2eissn
0090-4295issn
1527-9995pii
S0090-4295(07)02518-6journal_volume
72pub_type
杂志文章相关文献
UROLOGY文献大全abstract：OBJECTIVE:To determine if same day catheter removal is feasible in a select population after holmium laser enucleation of the prostate (HoLEP). METHODS:We performed an analysis of patients undergoing HoLEP at our institution who underwent same-day catheter removal after HoLEP. All HoLEPs were performed with Moses 2.0 ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.09.038
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVES:To compare the results of retroperitoneal laparoscopic versus open nephrectomy for benign renal diseases in children. METHODS:From January 1999 to February 2003, retroperitoneal nephrectomy or nephroureterectomy was performed in 23 consecutive children (7 girls and 16 boys). The median patient age was 4 yea...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2003.11.040
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVES:To investigate an alternative technique using an onlay patch of porcine small intestine submucosa (SIS) allograft to bridge a ureteral defect. For ureteral strictures that fail endourologic management, few options are available for minimally invasive repair or reconstruction. Although laparoscopic interposit...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)01890-3
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVES:To perform a randomized comparative study investigating the urodynamic effects of functional magnetic stimulation (FMS) and functional electrical stimulation (FES) on the inhibition of detrusor overactivity. METHODS:Thirty-two patients with urinary incontinence due to detrusor overactivity (15 men, 17 women...
journal_title：Urology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0090-4295(00)00779-2
更新日期：2000-11-01 00:00:00
abstract：:Laparo-endoscopic single-site (LESS) renal surgery is steadily gaining momentum. LESS by itself is technically challenging, with a potentially increased procedural risk, and the presence of major vascular anomaly may increase the risk of intraoperative mishap. Here we present a case of left transperitoneal LESS radica...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.12.007
更新日期：2012-03-01 00:00:00
abstract：:To evaluate the effect of prostaglandin inhibition on the renal blood flow of the ischemic kidney, we administered indomethacin to 10 anesthetized dogs with renal artery stenosis and contralateral nephrectomy. Following the operation to produce renal ischemia, there was an increase of blood pressure associated with an...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(79)90495-3
更新日期：1979-09-01 00:00:00
abstract：OBJECTIVES:To report on the initial case and surgical technique of laparoendoscopic, single-site, subtotal cystectomy and augmentation enterocystoplasty performed through a single multichannel transumbilical port in a patient with neurogenic bladder. METHODS:Laparoendoscopic, single-site, subtotal cystectomy and augme...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.01.019
更新日期：2009-06-01 00:00:00
abstract：:Chromaffin cell tumors are derived from neural crest cells and can produce and secrete catecholamines. Classic symptoms include headache, palpitations, diaphoresis, and hypertension. Diagnosis is typically in adulthood, and metastatic disease is rarely found. Genetic testing is suggested with young age, extra-adrenal ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2016.05.028
更新日期：2016-12-01 00:00:00
abstract：:Serial carcinoembryonic antigen (CEA) assays were conducted in patients with endocrine-unresponsive prostatic adenocarcinoma who were being treated with multidrug chemotherapy. Changes in CEA correlated with the clinical status of the patient in 70 per cent of the determinations and were more accurate than acid phosph...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(76)90517-3
更新日期：1976-12-01 00:00:00
abstract：:The results of bacterial susceptibility testing in 2,413 urine specimens obtained from patients with urinary tract infections indicated that in a high percentage clinical response could be predicted without the need for antimicrobial sensitivity testing. Simply identifying the infecting organism will provide the clini...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(82)90622-7
更新日期：1982-05-01 00:00:00
abstract：INTRODUCTION:To describe the technique of injecting Lipiodol in the submucosa of the urinary bladder wall as a novel modality to improve localization of muscle-invasive bladder tumors before image-guided radiation therapy. TECHNICAL CONSIDERATIONS:Eight patients underwent submucosal Lipiodol injections at transurethra...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.09.058
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVES:Despite the introduction of the new World Health Organization 2004 grading classification, the grading of urothelial carcinoma remains difficult and subjective. The aim of this study was to evaluate the role of computer-assisted image morphometric analysis as a tool to improve the objectivity of histologic g...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.09.003
更新日期：2007-11-01 00:00:00
abstract：:Carcinoma metastatic to the ureter, representing hematogenous or lymphatic spread from a distant primary neoplasm, was diagnosed in 39 patients. Although the lesions are uncommon and usually represent late manifestations of malignant disease, earlier recognition and relief of urinary tract obstruction may allow for im...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(79)90075-x
更新日期：1979-10-01 00:00:00
abstract：OBJECTIVES:The objectives of the study were to evaluate morbidity, survival, and quality of life (QoL) in elderly patients with invasive bladder cancer who received an orthotopic neobladder or an ileal conduit. METHODS:The charts of 85 patients, aged 75 or older (median age 78), who had received an ileal conduit (n = ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.11.125
更新日期：2008-05-01 00:00:00
abstract：:We present an unusual case of recurrent reflux on the right side after bilateral vesicoureteroplasty with modified Hutch I technique. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(81)90266-1
更新日期：1981-04-01 00:00:00
abstract：OBJECTIVES:To compare postoperative morbidity and mortality in a concurrent and contemporary series of patients who underwent radical cystectomy with ileal conduit versus orthotopic neobladder. METHODS:The data of 198 patients were reviewed, 117 with orthotopic reconstruction and 81 with ileal conduit during a 5-year ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(99)00619-6
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVES:To examine whether radical prostatectomy (RP) conducted before 4 or 6 weeks after prostate biopsy is associated with surgical difficulty or efficacy. Many urologists recommend an interval of at least 4 to 6 weeks between prostate biopsy and RP. METHODS:Using our surgical database, we identified 2996 men und...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.01.089
更新日期：2007-06-01 00:00:00
abstract：:Retrospective review of 298 extracorporeal shock wave lithotripsy (ESWL) treatments was undertaken to determine the factors which influence radiation exposure during ESWL. Fluoroscopy time averaged 160 seconds (3-509), and the average number of spot films taken per patient was 26 (5-68). The average stone burden was 1...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(87)90433-x
更新日期：1987-12-01 00:00:00
abstract：:A probability sample of noninstitutionalized elderly people in Washtenaw County, Michigan, was interviewed to determine the relationship between urinary incontinence and various health conditions. The results show that between both male and female respondents physical mobility problems, specific neurologic symptoms, l...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(90)80211-5
更新日期：1990-08-01 00:00:00
abstract：:Twenty-one patients with high-stage transitional cell carcinoma (TCC) of the bladder were treated with a combination of methotrexate, vinblastine, doxorubicin (Adriamycin), and cisplatin (M-VAC). There was a minimum follow-up of thirty-six months (range 36-45) in all patients. Patients were divided into three groups: ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(89)90440-8
更新日期：1989-12-01 00:00:00
abstract：OBJECTIVES:To report our contemporary experience with ureterocalicostomy to determine whether the indications or results have changed in modern practice. Ureterocalicostomy is a well-established treatment for patients with complicated ureteropelvic junction (UPJ) obstruction and other forms of proximal ureteral obstruc...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2004.08.024
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVES:To investigate clinical features of Chinese patients with severe primary erectile dysfunction (S-PED) and to identify the ideal treatment options for this population. METHODS:Patients with PED were screened for enrollment in our study. Sexual history, marital status, and erectile function were evaluated by ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.12.008
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVES:To describe the use of transurethral electrovaporization in the treatment of large superficial bladder tumors. METHODS:The records of 9 consecutive patients with large superficial bladder tumors treated by transurethral electrovaporization were retrospectively reviewed. All patients underwent vaporization o...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/S0090-4295(96)00155-0
更新日期：1996-08-01 00:00:00
abstract：:Renal cell carcinoma is a highly vascular tumor with the propensity to propagate along venous channels. Vena cava tumor thrombi are reported to occur in approximately 4-10 per cent of cases and requires modification of the standard radical nephrectomy. We report the first 3 cases of vena caval tumor thrombus emanating...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(84)90065-7
更新日期：1984-06-01 00:00:00
abstract：OBJECTIVES:To perform a prospective evaluation of the long-term effects of hysterectomy on symptoms of urinary incontinence. METHODS:A prospective observational cohort study was performed. Preoperatively, 120 consecutive patients undergoing hysterectomy for benign conditions answered a questionnaire on symptoms associ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.04.001
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To evaluate feasibility of percutaneous nephrolithotomy (PCNL) for complex nephrolithiasis in patients 80 years of age and older compared to younger individuals. METHODS:From an institutional IRB-approved database, 1,647 patients were identified who underwent PCNL from 1999 to 2019. Patients were stratified ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2019.08.044
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy and safety of collagenase Clostridium histolyticum (CCH) for the management of penile deformities in patients presenting with different categories of atypical Peyronie's disease (PD). METHODS:We conducted a retrospective review of charts of patients who presented to a men's health cl...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.05.076
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:To demonstrate the safety and efficacy of flexible ureteroscopy (FURS) and holmium laser lithotripsy as a valuable treatment of bilateral multiple intrarenal stones and stratify the efficacy by stone burdens ≤ 20 and >20 mm. METHODS:Twenty-five patients with bilateral multiple intrarenal stones were treated ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2012.05.013
更新日期：2012-10-01 00:00:00
abstract：:The association of tapetoretinal degeneration with familial juvenile nephronophthisis is a rare oculorenal syndrome. Without treatment all children die of renal failure prior to adulthood. Information regarding renal transplantation is lacking in these children. This article reflects our experience in two children aff...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(87)90178-6
更新日期：1987-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the role of intravesical prostatic protrusion (IPP) as a predictive factor for adverse clinical outcomes in patients treated with dutasteride for lower urinary tract symptoms secondary to benign prostatic enlargement (BPE). METHODS:In total, 111 patients treated with dutasteride for symptomatic B...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2016.01.009
更新日期：2016-05-01 00:00:00
