Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity.

abstract：:In vertebrates, adipose tissue is the main storage site for lipids within specialized lipid-laden mature adipocytes. While many species have evolved cells capable of lipid storage, the adipocyte represents a unique specialized cell involved in fuel storage, endocrine, nervous and immune function. However, the adipocyt...

journal_title：Adipocyte

authors： Church C,Horowitz M,Rodeheffer M

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:UCP2 is a mitochondrial membrane transporter expressed in white adipose tissue and involved in regulation of energy balance. In this present study, we examined the depot specific comparison of UCP2 gene expression in different metabolic states, in order to explore the potential role of UCP2 in human obesity a...

journal_title：Adipocyte

authors： Mahadik SR,Lele RD,Saranath D,Seth A,Parikh V

更新日期：2012-04-01 00:00:00

abstract：:The ability of n-3 long chain polyunsaturated fatty acids (PUFAs) to prevent high fat diet-induced obesity in rodents is well documented. Evidence for a similar effect in humans is, however, limited. Intervention studies in humans are inconclusive and epidemiological studies are dichotomous. Our recent finding that su...

journal_title：Adipocyte

authors： Madsen L,Kristiansen K

更新日期：2012-07-01 00:00:00

abstract：:Adipose tissue expansion in obesity involves a series of cycles of adipocyte hyperplasia, hypertrophy and hypoplasia due to alterations in adipogenesis, adipocyte cellular metabolism and cell death, respectively. Increased frequency of these cycles may lead to deterioration of adipocyte function and viability, acceler...

journal_title：Adipocyte

authors： White UA,Tchoukalova YD

更新日期：2012-10-01 00:00:00

abstract：:Inflammation involving adipose tissue is regarded as one of the major molecular mechanisms underlying obesity-related insulin resistance. Recent studies have suggested a series of angiotensin II receptor blockers (ARBs) to improve insulin resistance or protect against the development of diabetes mellitus. We previousl...

journal_title：Adipocyte

authors： Iwashita M,Nakatsu Y,Sakoda H,Fujishiro M,Kushiyama A,Fukushima T,Kumamoto S,Shinjo T,Kamata H,Nishimura F,Asano T

更新日期：2013-01-01 00:00:00

abstract：:Inflammation accompanies obesity and its comorbidities-type 2 diabetes, non-alcoholic fatty liver disease and atherosclerosis, among others-and may contribute to their pathogenesis. Yet the cellular machinery that links nutrient sensing to inflammation remains incompletely characterized. The protein deacetylase sirtui...

journal_title：Adipocyte

authors： Kotas ME,Gorecki MC,Gillum MP

更新日期：2013-04-01 00:00:00

abstract：:In the United States, obesity is a burgeoning health crisis, with over 30% of adults and nearly 20% of children classified as obese. Insulin resistance, a common metabolic complication associated with obesity, significantly increases the risk of developing metabolic diseases such as hypertension, coronary heart diseas...

journal_title：Adipocyte

authors： McCurdy CE,Klemm DJ

更新日期：2013-07-01 00:00:00

abstract：:The aim of this study is to analyze how maternal diet during the lactational period influences the adipose tissue response to chronic caloric restriction in offspring. Lactating dams were subjected to one of three treatments: 50% food restriction (FR), ad lib standard chow (AL), or ad lib high-fat diet (HF). Juveniles...

journal_title：Adipocyte

authors： Mackay H,Khazall R,Patterson ZR,Wellman M,Abizaid A

更新日期：2013-10-01 00:00:00

abstract：:FNDC5 (fibronectin domain-containing [protein] 5) was initially discovered and characterized by two groups in 2002. In 2011 FNDC5 burst into prominence as the parent of irisin, a small protein containing the fibronectin type III domain. Irisin was proposed to be secreted by skeletal muscle cells in response to exercis...

journal_title：Adipocyte

authors： Erickson HP

更新日期：2013-10-01 00:00:00

abstract：:Growth of adipose tissue involves differentiation of preadipocytes into mature lipid-containing adipocytes. The matrix metalloproteinases (MMPs) are known regulators of adipose tissue biology, and previous studies suggested a key role for gelatinase B (MMP-9) in adipogenesis. In the present study we have evaluated a p...

journal_title：Adipocyte

authors： Bauters D,Van Hul M,Lijnen HR

更新日期：2014-01-01 00:00:00

abstract：:White adipose tissue is considered to have high plasticity. Dynamic, abnormal expansion of white adipose tissue leads to obesity and associated metabolic disorders. Due to technical limitations, the life cycle and turnover rates of different white adipose depots during development and under various physiological condi...

journal_title：Adipocyte

authors： Wang QA,Scherer PE

更新日期：2014-04-01 00:00:00

abstract：:S100B is a calcium binding protein found in adipose tissue; however, relatively little is known about the physiologic regulation or distribution of the protein within this organ. We examined plasma S100B concentration and white adipose tissue (WAT) s100b mRNA levels in lean and diet-induced obese (DIO) mice. Plasma S1...

journal_title：Adipocyte

authors： Buckman LB,Anderson-Baucum EK,Hasty AH,Ellacott KLj

更新日期：2014-07-01 00:00:00

abstract：:This study examined the alterations in triglyceride (TG) breakdown and storage in subcutaneous inguinal (SC Ing) and epididymal (Epid) fat depots following chronic endurance training. Male Wistar rats were either kept sedentary (Sed) or subjected to endurance training (Ex) at 70-85% peak VO2 for 6 weeks. At weeks 0, 3...

journal_title：Adipocyte

authors： Pistor KE,Sepa-Kishi DM,Hung S,Ceddia RB

更新日期：2014-11-14 00:00:00

abstract：:Fermentation of dietary fibers by colonic microbiota generates short-chain fatty acids (SCFAs), e.g., propionic acid and butyric acid, which have been described to have "anti-obesity properties" by ameliorating fasting glycaemia, body weight and insulin tolerance in animal models. In the present study, we therefore in...

journal_title：Adipocyte

authors： Heimann E,Nyman M,Degerman E

更新日期：2014-11-14 00:00:00

abstract：:Adipose tissue remodeling occurs in obesity, characterized by adipocyte hypertrophy and increased infiltration of macrophages which also shift to a proinflammatory phenotype. Factors derived from these macrophages significantly alter adipocyte function, such as repressing adipogenesis, inducing inflammatory response a...

journal_title：Adipocyte

authors： Bing C

更新日期：2015-01-07 00:00:00

abstract：:Amyloid-β (Aβ) peptide, which is generated from proteolytic cleavage of amyloid precursor protein (APP), is a key molecule involved in the pathology of Alzheimer disease. Both APP and Aβ peptides are expressed in adipose tissue, however it is currently unclear whether Aβ can affect the key functions of adipose tissue....

journal_title：Adipocyte

authors： Wan Z,Mah D,Simtchouk S,Kluftinger A,Little JP

更新日期：2014-12-31 00:00:00

abstract：:Epidemiological studies initially demonstrated that maternal undernutrition leads to low birth weight with increased risk of adult-onset obesity. Maternal obesity and diabetes associated with high birth weight, excessive nutrition in neonates, and rapid catch-up growth also predispose offspring to fat accumulation. As...

journal_title：Adipocyte

authors： Lecoutre S,Breton C

更新日期：2014-12-10 00:00:00

abstract：:Adipose tissue plays a central role in the control of energy balance as well as in the maintenance of metabolic homeostasis. It was not until recently that the first evidences of the role of heat shock protein (Hsp) 90 and high molecular weight immunophilin FKBP51 have been described in the process of adipocyte differ...

journal_title：Adipocyte

authors： Toneatto J,Charó NL,Galigniana NM,Piwien-Pilipuk G

更新日期：2015-05-13 00:00:00

abstract：:The importance of ATP-Binding Cassette G1 (ABCG1) transporter in obesity was recently brought to light by recent findings uncovering its key role in adipogenesis with physiopathological consequences in human obesity. Thus, silencing of ABCG1 expression using an RNAi approach allows inhibition of adipocyte differentiat...

journal_title：Adipocyte

authors： Frisdal E,Le Goff W

更新日期：2015-03-09 00:00:00

abstract：:Adipose tissue is the energy buffer in mammals. The cellularity of adipose tissue has a major role in determining the response of adipose tissue to insulin action. A reduction in the ability of adipose tissue to store ingested caloric excess can lead to dyslipidemia and lipotoxicity, impacting insulin action systemica...

journal_title：Adipocyte

authors： Li Y,Periwal V,Cushman SW,Stenkula KG

更新日期：2015-12-08 00:00:00

abstract：:Exercise training results in adaptations to numerous organ systems and offers protection against metabolic disorders including obesity and type 2 diabetes, and recent reports suggest that adipose tissue may play a role in these beneficial effects of exercise on overall health. Multiple studies have investigated the ef...

journal_title：Adipocyte

authors： Stanford KI,Goodyear LJ

更新日期：2016-05-18 00:00:00

abstract：:Short-chain fatty acids (SCFAs), e.g. acetic acid, propionic acid and butyric acid, generated through colonic fermentation of dietary fibers, have been shown to reach the systemic circulation at micromolar concentrations. Moreover, SCFAs have been conferred anti-obesity properties in both animal models and human subje...

journal_title：Adipocyte

authors： Heimann E,Nyman M,Pålbrink AK,Lindkvist-Petersson K,Degerman E

更新日期：2016-10-28 00:00:00

abstract：:Aging is associated with progressive visceral white adipose tissue (WAT) expansion both in human and mouse. Importantly, WAT enlargement is initiated early in life, suggesting that molecular mechanisms underlying age-dependent obesity are activated at early stages of lifetime. Our recent study found that age-dependent...

journal_title：Adipocyte

authors： Li QOY,Soro-Arnaiz I,Aragonés J

更新日期：2017-04-03 00:00:00

abstract：:Lysyl oxidase (LOX) catalyzes the oxidative deamination of lysine residues in collagen and elastin, key components of connective tissue. LOX is synthesized as an inactive 50 kD pre-proenzyme, and secreted to the extracellular matrix where it is cleaved into an active 32 kD LOX, and an 18kD free propeptide (LOX-PP), pu...

journal_title：Adipocyte

authors： Griner JD,Rogers CJ,Zhu MJ,Du M

更新日期：2017-01-02 00:00:00

abstract：:The present study aimed to identify genes exhibiting concomitant obesity-dependent changes in DNA methylation and gene expression in adipose tissues in the mouse using diet-induced obese (DIO) C57BL/6J and genetically obese ob/ob mice as models. Mature adipocytes were isolated from epididymal and inguinal adipose tiss...

journal_title：Adipocyte

authors： Sonne SB,Yadav R,Yin G,Dalgaard MD,Myrmel LS,Gupta R,Wang J,Madsen L,Kajimura S,Kristiansen K

更新日期：2017-04-03 00:00:00

abstract：:Intuitively, excess caloric intake causes adipose tissue expansion. However, the signals and mechanisms by which this systemic trigger directs a local response in the adipose tissue are incompletely understood. Both hypertrophy of existing adipocytes and the generation of new adipocytes through differentiation of adip...

journal_title：Adipocyte

authors： Wong JC,Feldman BJ

更新日期：2017-10-02 00:00:00

abstract：:Our objectives were to investigate fatty acid composition variation amongst adipose tissue sites, breed effects on fat quality, and the relationship of pork fat quality to fresh pork quality. Barrows and gilts (n = 347) of five purebred and one commercial crossbred line were fed commercial swine diets with DDGS inclus...

journal_title：Adipocyte

authors： Testroet ED,Yoder CL,Testroet A,Reynolds C,O'Neil MR,Lei SM,Beitz DC,Baas TJ

更新日期：2017-10-02 00:00:00

abstract：:Non-communicable diseases (NCDs) such as cardiovascular disease, diabetes and cancer were responsible for 68% of all deaths worldwide in 2012. The regional distribution of lipid deposited within adipose tissue (AT) - so called body fat distribution (BFD) - is a strong risk factor for NCDs. BFD is highly heritable; how...

journal_title：Adipocyte

authors： Minchin JEN,Rawls JF

更新日期：2017-10-02 00:00:00

abstract：:Adipocytes were identified in human bone marrow more than a century ago, yet until recently little has been known about their origin, development, function or interactions with other cells in the bone marrow. Little functional significance has been attributed to these cells, a paradigm that still persists today. Howev...

journal_title：Adipocyte

authors： Horowitz MC,Berry R,Holtrup B,Sebo Z,Nelson T,Fretz JA,Lindskog D,Kaplan JL,Ables G,Rodeheffer MS,Rosen CJ

更新日期：2017-07-03 00:00:00

abstract：:Obesity is currently the most extended metabolic disturbance worldwide favoring the development of cardiometabolic alterations such as type 2 diabetes, hypertension, and dyslipidemia. Obesity and the metabolic syndrome (MS) are characterized by an increase in circulating leptin concentrations, in parallel to a decreas...

journal_title：Adipocyte

authors： Frühbeck G,Catalán V,Rodríguez A,Gómez-Ambrosi J

更新日期：2018-01-02 00:00:00