Abstract：
:Isoflavones are suitable guest molecules for inclusion complex formation with cyclodextrins (CDs). The molecular encapsulation with CDs results in a solid, molecularly dispersed form and in a significantly improved aqueous solubility of isoflavones. Genistein, a key isoflavone constituent of Ononidis spinosae radix was found to form a supramolecular, non-covalent inclusion complex with both beta-cyclodextrin (beta-CD) and gamma-cyclodextrin (gamma-CD), while it did not form a stable complex with alpha-CD. The guest genistein was found to spatially located in the less polar cavity of cyclodextrin. The isolated binary genistein/CD complexes appeared novel crystalline lattices. The in vitro dissolution of genistein entrapped into both beta- and gamma-CD, significantly surpassed that of the plain isoflavone.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Daruházi AE,Szente L,Balogh B,Mátyus P,Béni S,Takács M,Gergely A,Horváth P,Szoke E,Lemberkovics Edoi
10.1016/j.jpba.2008.06.007subject
Has Abstractpub_date
2008-11-04 00:00:00pages
636-40issue
3eissn
0731-7085issn
1873-264Xpii
S0731-7085(08)00350-6journal_volume
48pub_type
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