Ascorbate-dependent and ascorbate-independent Mn porphyrin cytotoxicity: anticancer activity of Mn porphyrin-based SOD mimics through ascorbate-dependent and -independent routes.

abstract：:Oxidative stress, growth factor starvation, and activation of the Fas/APO-1/CD95 receptor all induce apoptosis in a variety of cell-types, including the established human Jurkat T-cell line. Oxidative stress, in the form of exposure of the cells to a bolus dose of hydrogen peroxide, results in intralysosomal, iron-cat...

journal_title：Redox report : communications in free radical research

authors： Brunk UT,Svensson I

更新日期：1999-01-01 00:00:00

abstract：:The relative activities of some hydrogen-donating antioxidants were assessed by comparing their activities with that of Trolox (Trolox equivalent antioxidant capacity, TEAC) for scavenging the ABTS radical cation (ABTS.+) generated in the aqueous phase. We have verified, however, that TEAC values may change with the c...

journal_title：Redox report : communications in free radical research

authors： Mira L,Silva M,Rocha R,Manso CF

更新日期：1999-01-01 00:00:00

abstract：:Liver oxidative stress, Kupffer cell functioning, and cell injury were studied in control rats and in animals subjected to L-3,3',5-tri-iodothyronine (T3) and/or acute iron overload. Thyroid calorigenesis with increased rates of hepatic O2 uptake was not altered by iron treatment, whereas iron enhanced serum and liver...

journal_title：Redox report : communications in free radical research

authors： Boisier X,Schön M,Sepúlveda A,Basualdo A,Cornejo P,Bosco C,Carrión Y,Galleano M,Tapia G,Puntarulo S,Fernández V,Videla LA

更新日期：1999-01-01 00:00:00

abstract：:An overview of the biochemical photophysiology of tropical, reef-building corals is presented with a discussion on the biosynthetic relationship between natural UV-absorbing sunscreens and certain antioxidant functions in marine organisms. Our studies reveal that marine organisms, including 'UV-extremophilic' bacteria...

journal_title：Redox report : communications in free radical research

authors： Dunlap WC,Shick JM,Yamamoto Y

更新日期：1999-01-01 00:00:00

abstract：:There is growing public interest in traditional medicine. PADMA 28, a multicompound herbal preparation derived from Tibetan medicine, has proven efficacy in some clinical trials and tests at the cellular level. We report here on studies of PADMA 28 at the molecular level. Extracts of PADMA 28 contain both reducing and...

journal_title：Redox report : communications in free radical research

authors： Suter M,Richter C

更新日期：2000-01-01 00:00:00

abstract：:Lymphocytic 5'-ectonucleotidase (NT) activity previously has been shown to be reduced in patients with a high pro-oxidant state. This study shows that NT activity is decreased in vitro by exposure to superoxide anions and that ascorbate protects against this effect. Also, a putative high pro-oxidant state in vivo, as ...

journal_title：Redox report : communications in free radical research

authors： Chalmers AH,Blake-Mortimer JS,Winefield AH

更新日期：2000-01-01 00:00:00

abstract：:Previous studies have suggested that the jaggedness of the healed or healing infarct edge influences cardiac electrical stability. However, these findings have been based on histological observations rather than quantitative measurements. The aim of this study was to assess infarct jaggedness by calculating its fracta...

journal_title：Redox report : communications in free radical research

authors： McLachlan CS,Jelinek HF,Kummerfeld SK,Rummery NM,Jusuf PR,Hambly B,McGuire MA

更新日期：2000-01-01 00:00:00

abstract：:The first complete mechanistic analysis of halide ion oxidation by a peroxidase was that of iodide oxidation by horseradish peroxidase. It was shown conclusively that a two-electron oxidation of iodide by compound I was occurring. This implied that oxygen atom transfer was occurring from compound I to iodide, forming ...

journal_title：Redox report : communications in free radical research

authors： Dunford HB

更新日期：2000-01-01 00:00:00

abstract：:The enzyme, thyroid peroxidase (TPO), is a dominant antigen in thyroid autoimmune diseases. Autoantibodies recognised two major dominant conformational epitopes termed A and B. The epitopes have been defined by mAbs, but the amino acid residues which constitute these determinants remain unknown. Using a model of TPO, ...

journal_title：Redox report : communications in free radical research

authors： Gardas A,Watson PF,Hobby P,Smith A,Weetman AP,Sutton BJ,Banga JP

更新日期：2000-01-01 00:00:00

abstract：:The effect of osmotic stress and dehydration on maize catalase transcript accumulation was examined in leaves of abscisic acid (ABA)-deficient and ABA-insensitive mutants. We have found that the response of Cat1 to osmotic stress and dehydration is not via an ABA-mediated pathway in young leaves, suggesting that there...

journal_title：Redox report : communications in free radical research

authors： Guan LM,Scandalios JG

更新日期：2000-01-01 00:00:00

abstract：:Telomerase is a specialized ribonucleoprotein enzyme complex which prevents the loss of the telomere. The activity of telomerase can be up- and down-regulated by various oxidative stresses but the effect of physical exercise is not known, whereas the modifying effect of cancer on telomerase activity is well documented...

journal_title：Redox report : communications in free radical research

authors： Radak Z,Taylor AW,Sasvari M,Ohno H,Horkay B,Furesz J,Gaal D,Kanel T

更新日期：2001-01-01 00:00:00

abstract：:To investigate the possible role of oxygen free radicals and oxidant stress in the toxic effects of phenoxyherbicides, we studied the in vitro effect of 4-chlorophenoxyacetic acid (4-CPA) on various human erythrocyte antioxidant enzymes, namely glucose-6-phosphate dehydrogenase, catalase, selenium-dependent glutathion...

journal_title：Redox report : communications in free radical research

authors： Alicigüzel Y,Ozdem S,Demir AY,Unal F,Kumbul D,Ozdem SS,Perry G,Smith MA

更新日期：2001-01-01 00:00:00

abstract：:This study examined the contribution of catalase (CAT) and superoxide dismutase (SOD) in the overall antioxidant response to norflurazon (NF)-induced oxidative stress in leaves, mesocotyls and scutella of maize (Zea mays). Maize catalase null mutants were used to provide insights into the role(s) of these isozymes. A ...

journal_title：Redox report : communications in free radical research

authors： Jung S,Kernodle SP,Scandalios JG

更新日期：2001-01-01 00:00:00

abstract：:Haptoglobin (Hp) has been known to be associated with the host defence response to infection and inflammation. The biological functions of Hp can be related to its ability to bind haemoglobin or to modulate immune response. Hp is expressed at a high level in lung cells, yet its protective role(s) in the lung is not kn...

journal_title：Redox report : communications in free radical research

authors： Yang F,Haile DJ,Coalson JJ,Ghio AJ

更新日期：2001-01-01 00:00:00

abstract：:Oxidation of low density lipoprotein (LDL) in vivo is thought to play a critical role in the initiation of atherosclerosis. F(2)-isoprostanes are compounds resulting from non-enzymatic oxidation of arachidonic acid and elevated levels are present in human atherosclerotic plaque. However, little is known about the form...

journal_title：Redox report : communications in free radical research

authors： Waddington EI,Puddey IB,Mori TA,Croft KD

更新日期：2002-01-01 00:00:00

abstract：:The ability of the widely employed therapeutic drugs 4-aminosalicylic acid and 5-aminosalicylic acid to act as singlet molecular oxygen (O(2)((1)delta(g))) scavengers was investigated at pH 7 and pH 12. The isomer 3-aminosalicylic acid was also included in the study for comparative purposes. All three compounds quench...

journal_title：Redox report : communications in free radical research

authors： Yppolito R,Pappano N,Debattista N,Miskoski S,Bertolotti SG,García NA

更新日期：2002-01-01 00:00:00

abstract：:The notion of transmembrane electron transport is usually associated with mitochondria and chloroplasts. However, since the early 1970s, it has been known that this phenomenon also occurs at the level of the plasma membrane. Ever since, evidence has accumulated for the existence of a plethora of transplasma membrane e...

journal_title：Redox report : communications in free radical research

authors： Ly JD,Lawen A

更新日期：2003-01-01 00:00:00

abstract：:Peroxiredoxins (Prx) are a recently identified family of proteins that have been shown to exhibit peroxidase activity, as well as other divergent functions. Of the six known members of the family, Prx4 is present as a secretable form in most tissues and as a membrane-bound form only in testes. We recently proposed tha...

journal_title：Redox report : communications in free radical research

authors： Matsuki S,Sasagawa I,Iuchi Y,Fujii J

更新日期：2002-01-01 00:00:00

abstract：:Vancomycin, a glycopeptide antibiotic, has a broad spectrum against methicillin-resistant Staphylococcus aureus (MRSA). Because vancomycin induces renal dysfunction, the dose and the duration of its administration are limited. The mechanism of vancomycin-induced renal dysfunction is not known. We recently synthesized ...

journal_title：Redox report : communications in free radical research

authors： Nishino Y,Takemura S,Minamiyama Y,Hirohashi K,Tanaka H,Inoue M,Okada S,Kinoshita H

更新日期：2002-01-01 00:00:00

abstract：:Aerobic cells are subjected to damaging reactive oxygen species (ROS) as a consequence of oxidative metabolism and/or exposure to environmental toxins. Antioxidants limit this damage, yet peroxidative events occur when oxidant stress increases. This arises due to increased radical formation or decreased antioxidative ...

journal_title：Redox report : communications in free radical research

authors： De Haan JB,Crack PJ,Flentjar N,Iannello RC,Hertzog PJ,Kola I

更新日期：2003-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease that mainly affects motor neurons. Despite intensive research efforts inspired by the mile-stone discovery linking the Cu/Zn superoxide dismutase 1 (SOD1) gene to a subset of familial cases, the mechanisms underlying disease patho...

journal_title：Redox report : communications in free radical research

authors： Zhu X,Perry G,Smith MA

更新日期：2003-01-01 00:00:00

abstract：:The malaria parasite Plasmodium falciparum is still a major threat to human health in the non-industrialised world mainly due to the increasing incidence of drug resistance. Therefore, there is an urgent need to identify and validate new potential drug targets in the parasite's metabolism that are suitable for the des...

journal_title：Redox report : communications in free radical research

authors： Müller S

更新日期：2003-01-01 00:00:00

abstract：:Adhesion of Plasmodium falciparum-infected erythrocytes to endothelial cells and to syncytiotrophoblasts lining the placenta is a key feature of malaria pathogenesis. P. falciparum erythrocyte membrane protein 1, a family of variable proteins, mediates adhesion to CD36 and intercellular adhesion molecule 1 in the syst...

journal_title：Redox report : communications in free radical research

authors： Rogerson SJ

更新日期：2003-01-01 00:00:00

abstract：:There is evidence of derangement of oxidant and antioxidant defense systems in depression. The present study examined the effects of fluoxetine and citalopram, standard selective serotonin re-uptake inhibitors, on lipid peroxidation, superoxide dismutase (SOD) activity and ascorbic acid concentrations. For this, a pro...

journal_title：Redox report : communications in free radical research

authors： Khanzode SD,Dakhale GN,Khanzode SS,Saoji A,Palasodkar R

更新日期：2003-01-01 00:00:00

abstract：:We report here on calculations at the hybrid DFT/HF (B3-LYP/6-31G(d, p)) level of the O-H bond dissociation enthalpy (O-H BDE) of phenylpropenoic acids (caffeic, ferulic, p-coumaric and cinnamic) and phenolic acids and related compounds (gallic, methylgallate, vanillic and gentisic) in order to gain insight into the u...

journal_title：Redox report : communications in free radical research

authors： Giacomelli C,Miranda Fda S,Gonçalves NS,Spinelli A

更新日期：2004-01-01 00:00:00

abstract：:Recent investigations have demonstrated that the signaling of hypoxia-re-oxygenation is a major contributing pathway leading to gastric mucosal injury induced by stress, non-steroidal anti-inflammatory drugs, and Helicobacter pylori. The aim of the present study was to perform a gene expression analysis on the gastric...

journal_title：Redox report : communications in free radical research

authors： Katada K,Naito Y,Shimozawa M,Mizushima K,Kuroda M,Takagi T,Kokura S,Ichikawa H,Yoshida N,Matsui H,Yoshikawa T

更新日期：2004-01-01 00:00:00

abstract：:The mechanisms of H2O2-induced Ca2+ release from intracellular stores were investigated in human umbilical vein endothelial cells. It was found that U73122, the selective inhibitor of phospholipase C, could not inhibit the H2O2-induced cytosolic Ca2+ mobilization. No elevation of inositol 1,4,5-trisphosphate (IP3) was...

journal_title：Redox report : communications in free radical research

authors： Zheng Y,Shen X

更新日期：2005-01-01 00:00:00

abstract：:The involvement of reactive oxygen species (ROS) in the induction of DNA damage to Escherichia coli cells caused by UVC (254 nm) irradiation was studied. We verified the expression of the soxS gene induced by UVC (254 nm) and its inhibition by sodium azide, a singlet oxygen (1O2) scavenger. Additional results showed t...

journal_title：Redox report : communications in free radical research

authors： Gomes AA,Silva-Júnior AC,Oliveira EB,Asad LM,Reis NC,Felzenszwalb I,Kovary K,Asad NR

更新日期：2005-01-01 00:00:00

abstract：:Over the last few years, a relative decline of the morbidity and mortality of human immunodeficiency virus (HIV) infection in industrialised countries has been observed due to the use of a potent combined therapy known as high active antiretroviral therapies (HAARTs). It has led to a decrease of viral load and a quant...

journal_title：Redox report : communications in free radical research

authors： Gil L,Pérez D,Tápanes R,Pérez J,Grune T

更新日期：2005-01-01 00:00:00

abstract：:Kwashiorkor is a severe edematous form of malnutrition with high prevalence and lethality in many African countries, and repeatedly has been reported to be associated with oxidative stress. The therapy of kwashiorkor is still ineffective. In this pilot study, we tested the hypothesis that oral application of thiol-con...

journal_title：Redox report : communications in free radical research

authors： Becker K,Pons-Kühnemann J,Fechner A,Funk M,Gromer S,Gross HJ,Grünert A,Schirmer RH

更新日期：2005-01-01 00:00:00