Vacuolar myelinopathy of the brain and lamellar ichthyosis.

Abstract:

:A 13-month-old child with lamellar ichthyosis and numerous cutaneous and systemic infections died following an abrupt episode of severe hypotension. Postmortem examination revealed white matter vacuolation in the brain stem tegmentum and cerebellar hemispheres similar to that seen in toxicity from hexachlorophene, to which our patient was not exposed. The patient had been treated with many commonly used medications, including 13-cis-retinoic acid, a relatively new drug with apparent therapeutic benefit in hyperkeratotic dermatoses. This had been given systemically during the patient's last week of life. Possible relationships between the white matter lesions and extrinsic toxic agents are discussed.

journal_name

Cutis

journal_title

Cutis

authors

Sadick N,Sternberg PE

subject

Has Abstract

pub_date

1986-07-01 00:00:00

pages

29-32

issue

1

eissn

0011-4162

issn

2326-6929

journal_volume

38

pub_type

杂志文章

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