Abstract:
:We performed simultaneous acquisition of EEG-fMRI in seven patients with Unverricht-Lundborg disease (ULD) and in six healthy controls using self-paced finger extension as a motor task. The event-related desynchronization/synchronization (ERD/ERS) analysis showed a greater and more diffuse alpha desynchronization in central regions and a strongly reduced post-movement beta-ERS in patients compared with controls, suggesting a significant dysfunction of the mechanisms regulating active movement and movement end. The event-related hemodynamic response obtained from fMRI showed delayed BOLD peak latency in the contralateral primary motor area suggesting a less efficient activity of the neuronal populations driving fine movements, which are specifically impaired in ULD.
journal_name
Comput Intell Neuroscijournal_title
Computational intelligence and neuroscienceauthors
Visani E,Minati L,Canafoglia L,Gilioli I,Salvatoni L,Varotto G,Fazio P,Aquino D,Bruzzone MG,Franceschetti S,Panzica Fdoi
10.1155/2010/164278subject
Has Abstractpub_date
2010-01-01 00:00:00pages
164278eissn
1687-5265issn
1687-5273pub_type
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