Adjunctive micronutrient supplementation for pulmonary tuberculosis.

Abstract:

OBJECTIVE:To assess the effect of micronutrient supplementation on tuberculosis (TB) patient outcomes. MATERIAL AND METHODS:The randomized, double-blinded, placebo-controlled study was conducted in pulmonary TB patients undergoing directly observed treatment short course/ tratamiento acortado estrictamente supervisado (TAES/ DOTS) at IMSS in Ciudad Juarez, Chihuahua, Mexico, who were recruited during August 2005-July 2006. Consecutive patients received zinc and vitamin A supplements or matched placebo for four months. Dietary intake, blood zinc and vitamin A, immune response (IFN-gamma,TNF-alpha, and IL-10 mRNA), and sputum smear conversion were measured. RESULTS:The proportion of micronutrient compared to placebo group subjects with a negative sputum smear by month 3 was significantly increased (p= 0.03). This occurred subsequent to increased TNF-alpha and IFN-gamma and decreased IL-10 observed at month 2. Micronutrient supplementation appeared to accelerate the beneficial therapeutic effect of chemotherapy. CONCLUSIONS:The earlier elimination of bacilli from sputum was associated with improved zinc status and Th1 immune response. The therapeutic effect of vitamin A was less evident.

journal_name

Salud Publica Mex

journal_title

Salud publica de Mexico

authors

Armijos RX,Weigel MM,Chacon R,Flores L,Campos A

doi

10.1590/s0036-36342010000300001

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

185-9

issue

3

eissn

0036-3634

issn

1606-7916

pii

S0036-36342010000300001

journal_volume

52

pub_type

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