Abstract:
:Baicalin (BC)-rare earth metal complexes [BMCs (BC-Ce, BC-La, and BC-Y)] were synthesized by a complexation coordination method. A mouse tumor model with SMMC-7721 cells was used to examine BMCs for their anti-tumor activities in vivo. The results show that the three new BMCs, Na3Ce (C21H16O11)3·10H2O, Na2La (C21H16O11)2·8H2O, and Na2Y (C21H16O11)2·6H2O significantly inhibited SMMC-7721 cell proliferation, since the BMCs may induce the tumor apoptosis in a dose-dependent manner through decreasing cell membrane fluidity and mitochondrial membrane potential depolarization, blocking of the cell cycle at the G2/M phase, and increasing the expression of Bax and reducing the expression of Bcl-2. The effectiveness order of these three BCMs was as follows: BC-Ce > BC-La > BC-Y > BC. It is concluded that BC-Ce, BC-La, and BC-Y possess potent anti-tumor effects and may be a novel group of anti-tumor drugs. The novel baicalin-rare earth metal complexes (BMC) were synthesized, the anti-tumor effects of the BMC on SMMC-7721 cell analyzed comprehensively.
journal_name
Environ Geochem Healthjournal_title
Environmental geochemistry and healthauthors
Guo M,Gao X,Song H,Gu Y,Christie P,Wu S,Fan Xdoi
10.1007/s10653-020-00630-2subject
Has Abstractpub_date
2020-11-01 00:00:00pages
3851-3864issue
11eissn
0269-4042issn
1573-2983pii
10.1007/s10653-020-00630-2journal_volume
42pub_type
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