Abstract:
PURPOSE:Exercise training is established for the treatment of peripheral artery disease; however the additional benefit of pharmacologic therapy with exercise has not been studied. This trial tested the hypothesis that propionyl-L-carnitine (PLC), in combination with monitored home-based exercise training, would improve treadmill peak walking time (PWT) over exercise training alone. METHODS:Subjects with claudication were randomized to 6 months of therapy with PLC (2 g daily, n = 32) or matching placebo (n = 30). After supervised exercise instruction, all subjects performed exercise training sessions 3 times a week for 30 to 50 minutes/session and compliance was monitored by activity monitors and diary. Change in PWT was the primary outcome measure with other functional assessments predefined as secondary endpoints. RESULTS:After 6 months of treatment, patients randomized to training and placebo had an increase in PWT of 218 ± 367 seconds, while those randomized to training plus PLC had an increase of 266 ± 243 seconds, P = .258. Across the total study cohort, the dose of exercise training (total number of minutes of exercise of at least moderate intensity) was correlated with the change in PWT (r = 0.259, P = .048), suggesting that the monitored exercise was effective in improving walking performance in both treatment arms. CONCLUSIONS:In all subjects, the increase in PWT from baseline to month 6 was correlated with the amount of exercise training. However, although favoring PLC, the combination of exercise training and PLC did not result in a statistically significant benefit in peak treadmill performance or quality of life compared with exercise alone.
journal_name
J Cardiopulm Rehabil Prevjournal_title
Journal of cardiopulmonary rehabilitation and preventionauthors
Hiatt WR,Creager MA,Amato A,Brass EPdoi
10.1097/HCR.0b013e3181f1fd65subject
Has Abstractpub_date
2011-03-01 00:00:00pages
125-32issue
2eissn
1932-7501issn
1932-751Xjournal_volume
31pub_type
杂志文章,多中心研究,随机对照试验abstract:PURPOSE:The purpose of this study was to examine emotional distress, alexithymia, and coping styles as predictors of cardiac rehabilitation (CR) outcomes and attendance. METHODS:Participants included 56 patients in an outpatient CR program (65% male, 59% white, M = 61.1 years) who completed self-report measures of emo...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0b013e318276864c
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Spontaneous coronary artery dissection (SCAD) is a nonatherosclerotic type of acute myocardial infarction that primarily affects young, healthy women without typical risk factors for heart disease. Few investigations have examined psychosocial variables in this population and none have looked at patient percept...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000330
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:To determine the utility of equations that use the 6-minute walk test (6MWT) results to estimate peak oxygen uptake ((Equation is included in full-text article.)o2) and peak work rate with chronic obstructive pulmonary disease (COPD) patients in a clinical setting. METHODS:This study included a systematic revi...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,评审
doi:10.1097/HCR.0000000000000129
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:Cardiac rehabilitation (CR) programs decrease morbidity and mortality rates in patients with coronary artery disease, the leading cause of death in Latin America. This study was carried out to assess the characteristics and current level of CR program implementation in South America. METHODS:We carried out a s...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,多中心研究
doi:10.1097/HCR.0b013e318272153e
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Hospitalization with acute exacerbation of chronic obstructive pulmonary disease (COPD) is common and costly to the health care system. Pulmonary rehabilitation (PR) can improve symptom burden and morbidity associated with COPD. The use of PR among Medicare beneficiaries is poor, and the use by Veterans Heal...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000357
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:Cardiorespiratory and skeletal muscle deconditioning occurs following coronary artery bypass graft surgery and hospitalization. Outpatient, phase 2 cardiac rehabilitation (CR) is designed to remediate this deconditioning but typically does not begin until several weeks following hospital discharge. Although an ...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000576
更新日期:2021-01-25 00:00:00
abstract:PURPOSE:Cardiac rehabilitation (CR) in patients with coronary heart disease (CHD) remains underutilized especially among older patients. The present study compares baseline characteristics and CR outcomes between younger and older patients participating in CR. METHODS:Comparisons were made between "younger" (<65 years...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0b013e3181ac7870
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:We evaluated the effectiveness of a computerized cardiac rehabilitation (CR) recruiting strategy instituted during the hospital discharge process after acute myocardial infarction (MI) or coronary artery bypass graft (CABG) surgery. The computerized referral was designed to enhance an already-established nurse-...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0b013e3181b4ca75
更新日期:2009-11-01 00:00:00
abstract:PURPOSE:Some patients with chronic obstructive pulmonary disease (COPD) fail to achieve health benefits with pulmonary rehabilitation (PR). Exercise intensity and load represent stimulus for adaptation but it is unclear whether inappropriate exercise intensity and/or load are affected by severity of COPD, which may aff...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000321
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:A primary goal of cardiac rehabilitation (CR) exercise is to increase cardiopulmonary fitness. The aim of this study was to identify characteristics of CR participants who fail to improve peak oxygen uptake (peakV(O(2))). METHODS:The study cohort included 385 consecutive patients with directly measured peakV(O...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0b013e3181b4c8bd
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:Physical inactivity, smoking, and excessive alcohol use are well-recognized modifiable risk factors for cardiovascular disease (CVD), yet uptake of strategies to mitigate these poor health behaviors varies widely among patients with cardiovascular disease. Part of this variation may be explained by health locus...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000350
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:The application of active video games (AVGs) during cardiac rehabilitation (CR) sessions could potentially facilitate patient adherence. The feasibility, safety, and efficacy of in-class AVG supplementation as an alternative to conventional phase 2 programs were investigated. METHODS:A pilot, evaluator-blinded...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,随机对照试验
doi:10.1097/HCR.0000000000000224
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:Body mass index (BMI) has prognostic value in patients with chronic lung disease. Pulmonary rehabilitation improves quality of life. This study investigated whether BMI predicts change in disease-specific quality of life following pulmonary rehabilitation. METHODS:Subjects (N = 61), who completed pulmonary reh...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0b013e3181e17607
更新日期:2010-09-01 00:00:00
abstract::Outcome measurement in cardiopulmonary rehabilitation is required for optimal assessment of program quality, effectiveness of treatments, and evaluation of patient progress. Recent position statements from the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR), American College of Cardiology,...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,评审
doi:10.1097/HCR.0b013e3181927843
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess the effects on exercise performance of supplementing a standard cardiac rehabilitation program with additional exercise programming compared to the standard cardiac rehabilitation program alone in elderly patients after heart surgery. METHODS:In this prospective, randomized ...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,随机对照试验
doi:10.1097/HCR.0b013e3181be7e32
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:Patients who attend cardiac rehabilitation programs have a high prevalence of multiple chronic conditions (MCCs). The extent to which different constellations of MCC influence lifestyle exercise in the year after completion of an outpatient phase 2 cardiac rehabilitation program (CRP) is unknown. Our objective ...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,随机对照试验
doi:10.1097/HCR.0000000000000211
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:Best practice guidelines for cardiac rehabilitation (CR) suggest routine screening for anxiety and depression, yet many patients are not screened nor do they receive mental health treatment. Protocols are required to identify those in need of care and to ensure that appropriate assistance is provided. METHODS:...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000276
更新日期:2018-05-01 00:00:00
abstract::Resistance exercise training (RET) is gaining broad acceptance as a complement to endurance exercise in the treatment of cardiovascular risk factors. This article reviews the most current and reliable literature regarding the biological mechanisms and potential clinical effectiveness of RET in the treatment of 2 major...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,评审
doi:10.1097/HCR.0b013e318199ff69
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:We investigated whether cardiac rehabilitation participation increases circulating endothelial progenitor cells (EPCs) and benefits vasculature in patients already on stable therapy previously shown to augment EPCs and improve endothelial function. METHODS:Forty-six of 50 patients with coronary artery disease ...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 临床试验,杂志文章
doi:10.1097/01.HCR.0000265031.10145.50
更新日期:2007-03-01 00:00:00
abstract:PURPOSE:The efficacy of alternative delivery models for a cardiac rehabilitation program (CRP) in low- and middle-income countries is not well documented. This study compared the traditional hospital-based CRP with a hybrid CRP in western Iran. METHODS:This observational study was conducted with postcoronary surgery p...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000087
更新日期:2015-01-01 00:00:00
abstract::Chronic obstructive pulmonary disease is a common, progressive disorder associated with disabling symptoms, skeletal muscle dysfunction, and substantial morbidity and mortality. Current national guidelines recommend pulmonary rehabilitation (PR) to improve dyspnea, functional capacity, and quality of life. Many PR exe...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,评审
doi:10.1097/HCR.0b013e318297fea4
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:After coronary artery bypass graft (CABG) surgery, many patients experience diminished sexual function and satisfaction. The present study aimed to investigate the effect of outpatient cardiac rehabilitation (OCR) on the level of sexual satisfaction among post-CABG patients. METHODS:A clinical trial was perfor...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,随机对照试验
doi:10.1097/HCR.0000000000000434
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:Peak oxygen uptake recovery delay (V˙o2peakRD), measured as the time until post-exercise oxygen uptake (V˙o2) decreases below V˙o2peak following maximal cardiopulmonary exercise testing (CPX), has been recognized as an abnormal response, associated with reduced cardiac output reserve during exercise in patients...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000502
更新日期:2020-11-01 00:00:00
abstract:INTRODUCTION:Pneumonectomy results in impairments of pulmonary function and exercise intolerance associated with respiratory limitations. However, exercise capacity and functional capacity are less known at long-term followup. The aims of this study were to assess exercise tolerance and functional capacity among long-t...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000085
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Walking exercise favorably affects cardiac risk factors (CRF) and reduces total and cardiovascular disease-related mortality. The purpose of this study was to describe walking levels, prospectively measured by pedometer, in individuals commencing phase II cardiac rehabilitation (CR) and to correlate step cou...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0b013e31818c3b6d
更新日期:2008-11-01 00:00:00
abstract:PURPOSE:Exercise is an important treatment modality for persons with chronic obstructive pulmonary disease (COPD), but factors influencing adherence have been examined infrequently. The purpose of this investigation was to explore adherence factors to a progressive resistance exercise program for persons with COPD. ME...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 临床试验,杂志文章
doi:10.1097/01.HCR.0000270686.78763.c8
更新日期:2007-05-01 00:00:00
abstract:PURPOSE:To compare exercise training intensity during standard cardiac rehabilitation (S-CR) versus hybrid-CR (combined clinic- and remote home-/community-based). METHODS:The iATTEND (improving ATTENDance to cardiac rehabilitation) trial is currently enrolling subjects and randomizing patients to S-CR versus hybrid-CR...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000569
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:Obstructive sleep apnea (OSA) is prevalent in patients with cardiovascular disease and is often undiagnosed. The purpose of this study was to determine the utility of communicating OSA risk with the patients in a diabetes and cardiac rehabilitation program (CRP) and primary care physicians. METHODS:Following a...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000186
更新日期:2016-11-01 00:00:00
abstract:PURPOSE:Patients hospitalized with a cardiac condition are less likely to attend cardiac rehabilitation (CR) if they are smokers despite the benefits of doing so. The present study sought to investigate how, if at all, a patient's decision to attend CR was influenced by his or her tobacco use post-discharge. METHODS:W...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000366
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:Outpatient cardiac rehabilitation (CR) participation after myocardial infarction (MI) reduces all-cause mortality; however, less is known about effects of CR on post-MI hospitalization. The study objective was to investigate effects of CR on hospitalization following acute MI among older adults. METHODS:Medica...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000452
更新日期:2020-03-01 00:00:00