Anticoagulation therapy: indications, monitoring, and complications.

Abstract:

:Anticoagulation for thromboembolic disease and bleeding, the main complication of anticoagulation therapy, are uncommon but are potentially life- or limb-threatening conditions that may present in the pediatric emergency department. Thromboembolic disease in children usually occurs as a complication of vascular access, primarily in children with congenital heart disease or cancer. However, complications of anticoagulation therapy used in the treatment of venous thromboembolism, pulmonary embolism, and blocked central venous catheter; arterial thromboembolism, including arterial ischemic stroke, Kawasaki disease, and after cardiac surgery, may warrant a visit to n the pediatric emergency department. Anticoagulation therapy may take the form of unfractionated heparin, low-molecular weight heparin, vitamin K antagonists, acetylsalicylic acid, or thrombolytic therapy. Monitoring anticoagulation therapy in children is very important and follows adult guidelines. Anticoagulant dosing may be adjusted based on activated partial thromboplastin time, anti-factor Xa level, and international normalized ratio.

journal_name

Pediatr Emerg Care

journal_title

Pediatric emergency care

authors

Long E,Pitfield AF,Kissoon N

doi

10.1097/PEC.0b013e31820461b1

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

55-61; quiz 62-4

issue

1

eissn

0749-5161

issn

1535-1815

pii

00006565-201101000-00017

journal_volume

27

pub_type

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